The invention discloses a processing method of fish collagen oligopeptide, which comprises the following steps: delimed and degreased dry scales are selected as raw material, after being treated with cleaning, pretreatment, enzymolysis, filtration, decolorization, taste escaping, desalinization, aseptic filtration, concentration, and spray drying, fish collagen oligopeptide powder is obtained; according to dry basis, the fish collagen oligopeptide powder contains: protein content of no less than 95 percent, ash content of less than 0.5 percent, and average molecular weight of 700Dalton. The product processed by the method of the invention has the advantages of high quality, colorlessness, no bitter taste or stink, low salt content, no poisonous or side effect, and short enzymolysis time, the resin filling used during the adsorption process is renewable and can be repeatedly used for a plurality of times, and the problems of wasting of resources and high ash content of the product caused by using the disposable activated charcoal are avoided, thus being widely applied in the fields of food, health products, medicine and cosmetics, etc.