Tibetan capillary extract and preparation method, medicine composition and use thereof

A technology for extracts and compositions, applied in the field of medicine, can solve the problems of uncertain component content, unknown components, complex components, etc.

Active Publication Date: 2009-04-01
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] As mentioned above, the products of Tibetan capillary plants obtained from the inventions and methods reported in Chinese patents on Tibetan capillary drugs (including Swertia genus medicinal plants) have complex components, most of which are unknown, and the content of each component is uncertain. Extracts with uncertain ratios between components

Method used

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  • Tibetan capillary extract and preparation method, medicine composition and use thereof
  • Tibetan capillary extract and preparation method, medicine composition and use thereof
  • Tibetan capillary extract and preparation method, medicine composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Example 1. The preparation process of the anti-hepatic fibrosis active ingredient group of Swertia vinifera in western Sichuan

[0110] Get 15 kilograms of western Sichuan Swertia medicinal materials, cut into sections (about 1.5-2.5 centimeters), place in a 200-liter extraction tank, extract three times with 150 liters of 95% ethanol at 70 ° C (3 times share 450 liters), and the extraction time is respectively 10 Hours, 8 hours, 8 hours. Combine the three extracts (about 400 liters) and concentrate them to one-fortieth of the original volume (about 10 liters) with a large rotary evaporator. 40 liters each, divided into four times, 10 liters each time for solvent distribution. The solvents were recovered separately to obtain about 1.1 kg of n-butanol. Dissolve the n-butanol part with 5 liters of distilled water, put it on a 30 kg macroporous resin column (AB-8) to separate, first elute with 500 liters of distilled water, then use 120 liters of 10%, 30%, 40%, respectiv...

Embodiment 2

[0115] Example 2. The preparation process of the anti-hepatic fibrosis active ingredient group of Swertia vinifera in western Sichuan

[0116] Get 1 kg of western Sichuan Swertia medicinal material, cut it into sections (about 1.5-2.5 cm), put it in a 10-liter extraction tank, and extract three times with 9 liters of 75% ethanol at 70 ° C (3 times share 27 liters), the extraction time is 10 liters respectively. Hours, 8 hours, 8 hours. Combine three extracts (about 20 liters) and concentrate them to one-fortieth of the original volume (about 0.5 liters) with a large rotary evaporator. 2 liters each, divided into four times, 0.5 liters each time for solvent distribution. The solvents were recovered separately to obtain about 61 grams of n-butanol. Dissolve the n-butanol part with 250 ml of distilled water, put it on a 2.4 kg macroporous resin column (HPD100) for separation, first elute with 30 liters of distilled water, then use 8 liters of 15%, 30%, 40%, and 60% , 80% and 9...

Embodiment 3

[0121] Example 3. The preparation process of the anti-hepatic fibrosis active ingredient of Swertia japonica in western Sichuan

[0122] Get 2 kilograms of western Sichuan Swertia medicinal materials, cut into sections (about 1.5-2.5 centimeters), place in a 20-liter extraction tank, extract three times with 20 liters of 30% ethanol at 70 ° C (3 times share 60 liters), and the extraction time is 8 Hours, 8 hours, 8 hours. Combine the three extracts (about 46 liters) and concentrate them to one-fortieth of the original volume (about 1 liter) with a large rotary evaporator. 4 liters each, divided into four times, 1 liter each time for solvent distribution. The solvents were recovered separately to obtain about 110 grams of n-butanol. Dissolve the n-butanol part with 500 milliliters of distilled water, put it on 4 kilograms of macroporous resin column (S-8) to separate, first use 35 liters of distilled water to elute, then successively use 10 liters of 10%, 25%, 40%, 60%, 80% ...

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Abstract

The invention provides a Tibetan virgate wormwood herb extract containing swertiamain, gentiopicroside, sweroside, mangiferin and isoorientin, and the weight ratio of the five ingredients is (0.04-0.71): (20-40): (1-15): (1.6-26): (0.01-0.16). The invention further provides a preparation method of the Tibetan virgate wormwood herb extract, a pharmaceutical composition containing the Tibetan virgate wormwood herb extract and a medical use of the Tibetan virgate wormwood herb extract. The Tibetan virgate wormwood herb extract can improve various indicators caused by liver injury, promote the reversal of the liver fibrosis process and better prevent liver cirrhosis.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to extracts of capillary wormwood, in particular to extracts of capillary wormwood and its preparation method, pharmaceutical composition and medical application. Background technique [0002] Tibetan Yinchen is a precious medicinal material used in Tibetan medicine to prevent and treat various diseases such as hepatitis, liver injury, liver fibrosis, and fatty liver. Phytochemical studies have shown that the main medicinal materials of Tibetan Capillary (Swertia in Western Sichuan, Indian Swertia, Swertia clam and Flower Anchor) plants contain iridoid glycosides, flavonoids and their glycosides, ketones and Its glycosides, triterpenes and other components. Among them, the split iridoid glycoside components swertiamarin, gentiopicroside, and swertigin have pharmacological effects such as protecting the liver, reducing enzymes, anti-inflammation, promoting liver injury recovery, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61K9/00A61P1/16C07H1/08
Inventor 魏立新杜玉枝肖远灿邹小艳
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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