The invention provides an organic rankine cycle air inflow supercharging internal combustion engine system and method. The system comprises an internal combustion engine, a gas compressor, an intercooler, a preheater, an evaporator, an expanding agent, an electric generator, a condenser, a liquid storage tank and a working medium pump. According to the organic rankine cycle, low-boiling-point organic matter serves as a working medium, the intercooler, the preheater and the evaporator sequentially absorb compression air heat, cooling liquid heat and engine tail gas waste heat, saturated steam or overheat steam is generated and enters an expanding machine for doing work, the electric generator is driven to generate power, and meanwhile, power is provided for the gas compressor for internal combustion engine air inflow supercharging. According to the system, on the one hand, the ORC expanding machine replaces a turbine in a turbine supercharging internal combustion engine, and equipment can be simplified; on the other hand, the working medium absorbs heat in a stair manner from different devices, the heat exchange temperature difference is small, the work doing energy loss is small, the internal combustion engine waste heat can be used to the maximum degree, the main energy use efficiency is maximum, and the whole system is efficient and environment-friendly.