The invention discloses a high tower tube ventilation cooling performance setting method and device and a tower tube. The method comprises the steps that S1, an initial value of the heat transfer amount of the target tower tube is calculated, and whether the heat transfer amount meets the required heat transfer amount demand or not is judged, and if not, the process goes to step S2; S2, an axial flow fan with specified radiating performance parameter setting is selected as an initial axial flow fan; and S3, the heat transfer amount of the target tower when the axial flow fan with the current setting is arranged on a first layer of platform of the target tower tube is calculated, whether the heat transfer amount meets the required heat transfer amount demand or not is judged, if not, the radiating performance parameter setting is adjusted, and the process returns to step S3, and if yes, the required axial flow fan setting is output. The device comprises a tower tube heat transfer amountjudgment unit, a selection unit and a judgment adjustment unit. Through the method and device, optimal setting of the tower tube ventilation cooling performance can be achieved in combination with the heat transfer characteristics of the high tower tube, and the advantages of the simple implementation method, high setting efficiency, good effect and the like are achieved.