2results about How to "Less prone to side effects" patented technology

This application relates to the field of platinum catalysts and discloses a preparation process for an anti-poisoning platinum catalyst, comprising the following steps: adding chloroplatinic acid and sodium tetrachloropalladate to ethanol, adding carbonate, stirring evenly, adding an organosilicon vinyl dual-capping agent, and heating to react to obtain a platinum / palladium complex; washing the precipitate with water, extracting, drying and filtering, and purifying by rotary evaporation to obtain a purified platinum / palladium complex; adding an organosiloxane complex to obtain a diluted platinum / palladium complex; adding terminal ethylene silicone oil, hydrogen-containing silicone oil, and a polymerization inhibitor, stirring, vacuum degassing, and freezing to obtain an anti-poisoning platinum catalyst; the organosiloxane complex in step S4 is composed of dimethyl silicone oil and dodecylpentasiloxane in a weight ratio of 1:(0.5-1). The anti-poisoning platinum catalyst of this application is applicable to the preparation of special modified polysiloxanes containing sulfur, phosphorus, and other elements, high-performance silicone rubber, and special silicone oils. It exhibits good stability, is not prone to catalyst poisoning, and has high catalytic efficiency.

This invention discloses a method for synthesizing an intermediate of retinoic acid, relating to the field of pharmaceutical organic synthesis technology, comprising the following steps: S1, in the presence of a base, 2-amino-3-chloropyridine and 4-bromopiperidine undergo a nucleophilic substitution reaction in solvent A to prepare compound III; S2, in the presence of a catalyst and ammonia solution, compound III undergoes an amination reaction in solvent B to prepare compound II; S3, compound II is dissolved in solvent C, and sequentially undergoes CDI cyclization and hydrogen chloride solution salt formation to prepare compound I, namely 1-(piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one. This invention is low-cost, uses mild reaction conditions, has a simple synthesis process, high yield, and eliminates the need for expensive and potentially unsafe excipients, effectively improving reaction safety, being environmentally friendly, and suitable for industrial production.