50results about How to "The hydrogenation reaction conditions are mild" patented technology

The invention provides a palladium-catalyzed method for asymmetric hydrogenation of 2-hydroxypyrazine compounds to synthesize chiral lactams, wherein: R is C 1‑6 Alkyl or aryl containing substituents, the substituents are F, Cl, Br, CF 3 , Me, MeO, Et, n At least one of Pr. The invention has easy-to-obtain raw materials, high product enantioselectivity and good yield, and its enantiomeric excess can reach 90%. The catalyst is cheap and easy to obtain, and has good air stability, and provides an atom-economical and environmentally friendly route for the asymmetric hydrogenation of 2-hydroxypyrazine compounds to synthesize chiral lactams. At the same time, the present invention is simple and practical to operate, high in yield, environmentally friendly and green, mild in reaction conditions, and has potential practical application value.

The invention discloses a method for synthesizing chiral fluoroamine by palladium catalytic asymmetric hydrogenation, wherein, the used catalysis system comprises a palladium chiral diphosphite complex. The reaction is carried out under the following conditions that: the temperature is 0-50 DEG C, the solvent is a 2,2,2-trifluoroethyl alcohol, the pressure is 1-42 atm, the ratio of the substrate to the catalyst is 50 : 1, the used metal precursor is palladium trifluoroacetate, the used chiral ligand is a chiral diphosphite ligand. The catalyst is prepared by stirring the palladium metal precursor and the chiral diphosphite ligand in acetone at room temperature, and then carrying out vacuum condensation. According to the invention, by the hydrogenation of imine containing trifluoromethyl, corresponding chiral amine containing trifluoromethyl is obtained, the enantiomeric excess can reach to 94 %; by the hydrogenation of imine containing perfluoroalkyl, corresponding chiral amine containing perfluoroalkyl is obtained, and the enantiomeric excess can reach to 86 %. The present invention has the advantages of simple and practical operation, high enantioselectivitiy, good yield, green atom economy of the reaction, and no environmental pollution.

A method for synthesizing chiral exocyclic amine by iridium-catalyzed asymmetric hydrogenation of quinoline-3-amine, the catalytic system used is chiral diphosphorus complex of iridium. The reaction can be carried out under the following conditions, temperature: 25-70°C; solvent: a mixed solvent of toluene / tetrahydrofuran (V / V=3:1); pressure: 2-14 atmospheres; the ratio of substrate to catalyst is 25 / l; The catalyst is a complex of (1,5-cyclooctadiene) iridium chloride dimer and a chiral bisphosphine ligand. For quinoline-3-amine, the corresponding chiral exocyclic amine derivative can be obtained, and its enantiomeric excess value can reach 94%. The invention has the advantages of simple and practical operation, readily available raw materials, high enantioselectivity and good yield, and the reaction has green atom economy and is environmentally friendly.

The invention relates to diphenylalkyl halide or diphenyl carboxylic acid and a simple and convenient synthesis method thereof. The method comprises the following steps of: after a bromobenzene derivative and magnesium form a Grignard reagent, reacting the Grignard reagent and lactone, and opening loop to obtain 1,1-diphenyl-diol; reacting the 1,1-diphenyl-diol under the condition of a mixed solvent of an organic solvent and an acid to form diphenylenol; reacting the diphenylenol, a halogen or a halide and triphenylphosphine in the organic solvent to form diphenylalkenyl halogen; and reacting the diphenylalkenyl halogen and hydrogen to form diphenylalkyl halide, or reacting the diphenylenol and hydrogen to form diphenyl alcohol; and reacting the diphenyl alcohol and CrO3 under the action of the organic solvent and the acid to form diphenyl carboxylic acid. The reaction raw materials are cheap; the reaction conditions are mild; and substitutional diphenylalkyl halide or diphenyl carboxylic acid compounds with different benzene rings can be synthesized.

The invention relates to the field of catalytic hydrogenation reaction, and discloses a hydrogenation catalyst, a preparation method and application thereof, and a method for hydrogenation reaction of phenols. The hydrogenation catalyst comprises a modified carrier and an active component loaded on the modified carrier, the active component is selected from at least one of Pd, Rh and Ru, and the modified carrier is obtained by containing an amino group The organosilylating agent is used to functionalize the carrier. The hydrogenation catalyst of the present invention has relatively high catalytic activity, and in the hydrogenation reaction of phenolic compounds, the hydrogenation catalyst can still be used at low temperature, low pressure and low hydrogen phenol mole Ratio of mild conditions to achieve high conversion of raw materials and product selectivity.