The application provides an application of a strain of Tolypocladium inflatum ZJPH2105 in preparing a chiral
aromatic alcohol through asymmetric reduction of an
aromatic ketone. The product obtained through
catalysis of the strain of Tolypocladium inflatum ZJPH2105 has an e.e. value of greater than 99.9%, the strain is green and safe, easy to cultivate, and rich in source, and the conversion process does not need to add expensive coenzyme, and has the characteristics of low cost, green and environment-friendly conversion process and the like. The application uses the strain of Tolypocladium inflatum ZJPH2105 as a biological catalyst to reduce 4'-bromo-2,2,2-trifluoroacetophenone, when the
substrate concentration is 10 mM, the yield of the target product (S)-1-(4-bromophenyl)-2,2,2-trifluoroethanol can reach 98.2%, and the e.e. value is greater than 99.9%.