Preparation method of quaternary ammonium salt type cationic povidone-iodine antibacterial material

A technology of povidone-iodine and antibacterial materials, which is applied in the directions of botanical equipment and methods, fungicides, and paints containing biocides, can solve problems such as inability to achieve antibacterial effects, inability to achieve long-term antibacterial effects, and affecting antibacterial effects, etc. Achieve good biocompatibility, large specific surface area, and avoid the loss of iodine

Inactive Publication Date: 2020-05-29
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, povidone iodine will dissociate under high temperature and high humidity conditions, which will affect its antibacterial effect and cannot achieve long-term antibacterial effect.
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Method used

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  • Preparation method of quaternary ammonium salt type cationic povidone-iodine antibacterial material
  • Preparation method of quaternary ammonium salt type cationic povidone-iodine antibacterial material
  • Preparation method of quaternary ammonium salt type cationic povidone-iodine antibacterial material

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Effect test

Embodiment 1

[0037] Embodiment 1 A kind of preparation method of quaternary ammonium salt type cationic povidone-iodine antibacterial material comprises the following steps:

[0038] ⑴Based on parts by mass (g), 1.00 parts of vinylpyrrolidone, 0.38 parts of methacrylamidopropyltrimethylammonium chloride, 1.50 parts of hydrophobic comonomer, 0.02 parts of 3-(methacryloyloxy)propyl After the trimethoxysilane is uniformly mixed, 0.01 part of potassium persulfate is added, and the mixture is uniformly mixed by ultrasonic to obtain a mixed solution.

[0039] Wherein: the hydrophobic comonomer refers to a mixture of 1.00 parts of methyl methacrylate and 0.30 parts of butyl acrylate.

[0040] (2) Under constant mechanical stirring at 200 r / min, slowly drop the mixed solution into deionized water whose mass is 10 times that of the solution. After the dropwise addition, continue the reaction at 60°C for 6 h to obtain the product A.

[0041] (3) Product A was centrifuged at 10,000 r / min for 15 minu...

Embodiment 2

[0043] Embodiment 2 A kind of preparation method of quaternary ammonium salt type cationic povidone-iodine antibacterial material comprises the following steps:

[0044] ⑴Based on parts by mass (g), after mixing 2.00 parts of vinylpyrrolidone, 1.50 parts of methacrylamidopropyltrimethylammonium chloride, 2.50 parts of hydrophobic comonomer, and 0.40 parts of vinyltrimethoxysilane , add 0.12 parts of ammonium persulfate, and mix uniformly by ultrasonic to obtain a mixed solution.

[0045] Wherein: the hydrophobic comonomer refers to a mixture of 1.00 parts of methyl methacrylate and 3.00 parts of butyl acrylate.

[0046] (2) Under constant mechanical stirring at 450 r / min, slowly drop the mixed solution into deionized water whose mass is 12 times its mass. After the dropwise addition, continue the reaction at 90°C for 2 h to obtain the product A.

[0047] (3) Product A was centrifuged at 12,000 r / min for 10 minutes, washed 5 times with distilled water, and then freeze-dried at...

Embodiment 3

[0049] Embodiment 3 A kind of preparation method of quaternary ammonium salt type cationic povidone-iodine antibacterial material comprises the following steps:

[0050] ⑴Based on parts by mass (g), 1.40 parts of vinylpyrrolidone, 0.88 parts of acrylamidopropyltrimethylammonium chloride, 1.80 parts of hydrophobic comonomer, 0.11 parts of 3-(methacryloyloxy)propyltrimethoxy After the base silane is mixed uniformly, 0.04 part of potassium persulfate is added, and the mixture is uniformly mixed by ultrasonic to obtain a mixed solution.

[0051] Wherein: the hydrophobic comonomer refers to a mixture of 1.00 parts of methyl methacrylate and 1.50 parts of butyl acrylate.

[0052] (2) Under constant mechanical stirring at 350 r / min, slowly drop the mixed solution into deionized water whose mass is 17 times its mass. After the dropwise addition, continue the reaction at 75°C for 4 h to obtain the product A.

[0053] (3) Product A was centrifuged at 12500 r / min for 8 minutes, washed w...

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Abstract

The invention relates to a preparation method of a quaternary ammonium salt type cationic povidone-iodine antibacterial material. The method comprises the following steps: (1) uniformly mixing vinyl pyrrolidone, a quaternary ammonium salt type cationic monomer, a hydrophobic comonomer and a silane coupling agent, adding an initiator, and carrying out ultrasonic mixing uniformly to obtain a mixed solution; (2) slowly dropwise adding the mixed solution into deionized water while stirring at a constant speed, and continuously reacting for 2-6 h at the temperature of 60-90 DEG C after drop-by-dropadding is finished so as to obtain a product A; (3) sequentially carrying out centrifugal separation, washing and freeze drying on the product A to obtain a quaternary ammonium salt type cationic polymer; and (4) under the protection of nitrogen, adding the quaternary ammonium salt type cationic polymer into an alcoholic solution of I2 for an iodination reaction to obtain a product B, performingwashing and suction filtration on the product B, and carrying out vacuum drying to obtain the product. The synthesis process is simple and efficient, and the obtained antibacterial material has broad-spectrum antibacterial activity and good biocompatibility and can be used for antibacterial research of products such as coatings, printing ink and dyes.

Description

technical field [0001] The invention relates to the technical field of polymer antibacterial, in particular to a preparation method of a quaternary ammonium salt type cationic povidone-iodine antibacterial material. Background technique [0002] Antibacterial materials refer to a new class of functional materials that can kill or inhibit the growth and reproduction of microorganisms. It has extremely broad application prospects in the medical field, household products, food packaging and other fields. With the increasing requirements for environmental sanitation, the research and application of antibacterial materials have received extensive attention. [0003] Povidone-iodine is a complex compound of polyvinylpyrrolidone and iodine. It is a yellow-brown to brown-red amorphous powder at room temperature. It has a slight odor and is easily soluble in water or ethanol. The aqueous solution is acidic and insoluble in ether, chloroform, acetone, and ethyl alcohol. alkanes and c...

Claims

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Application Information

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IPC IPC(8): C08F8/22C08F226/10C08F220/14C08F220/18C08F220/60C08F230/08A01N55/10A01N59/12A01P1/00A01P3/00C09D11/107C09D5/14C09D133/12C09D139/06
CPCC08F8/22C08F226/10C08F220/14A01N55/00A01N59/12C09D11/107C09D5/14C09D143/04
Inventor 王荣民李雪梅李毅铭董明明周生旗王斌何玉凤
Owner NORTHWEST NORMAL UNIVERSITY
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