Contrast agent based on iopamidol lipid derivative and its preparation method and use

A lipid derivative, iopamidol technology, applied in the field of biomedical materials, can solve the problems of large size, removal, easy and rapid extravasation and removal, etc., and achieves the effects of strong operability, mild reaction conditions and cheap raw materials
CN106831480BActive Publication Date: 2019-01-15PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2019-01-15

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Abstract

The invention discloses a contrast medium based on an iopamidol lipid derivative, as well as a preparation method and application of the contrast medium. The lipid molecule structure comprises both hydrophobic aliphatic chains and hydrophilic iopamidol groups which can be combined to form nanoparticle structures by selves in a water solution, and in addition, as the aliphatic chains and the iopamidol can be connected through degradable ester bonds, the biocompatibility of the contrast medium can be further improved; moreover, as covalent bonds in the molecule structures of such substances are connected with iopamidol functional groups, the content of iopamidol in nanoparticles can be increased, and meanwhile the problems that the contrast medium is released and leaked too early in the particle circulation process can be effectively avoided. The nanoparticles formed by lipid of the contrast medium can be used as a functional material which is used as a contrast medium and a carrier of various medicines and other contrast mediums, thereby having wide clinical application prospects.
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Description

Technical field

[0001] The present invention belongs to the field of biomedical materials, and relates to non-ionic X-ray contrast agents. More specifically, it relates to a preparation method of a class of novel structurally novel lipid derivatives containing iopamidol groups and intermediates thereof, and Used as a functional material in contrast agents and various carriers. technical background

[0002] Computed tomography (CT) is an imaging mode with high spatial and temporal resolution. The ability of CT to distinguish tissue is based on the basis that different tissues provide different degrees of X-ray attenuation, where the attenuation coefficient depends on the atomic number and electron density of the constituent elements in the tissue. The significant differences in absorption between bone, fat, air and water can produce high-contrast images of anatomical structures. However, in the absence of a contrast agent, not all tissues are fully identified, and the use of a t...

Claims

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