Refining method of iopamidol intermediate

Abstract

The invention belongs to the field of medicine synthesis, and particularly provides a refining method of an iopamidol intermediate, which is characterized in that a compound shown as a formula II is used for preparing a compound shown as a formula III of the iopamidol intermediate under the catalytic action of Lewis soft acid. According to the technical scheme, the high-purity and high-yield intermediate compound shown in the formula III can be obtained, the yield can reach 99.9%, the reaction is thorough, no raw material is left, the purity can reach 96% or above, and generation of a diiodo-substituted impurity 1 compound is thoroughly avoided. In addition, high-purity and high-yield iopamidol can be prepared by utilizing the intermediate compound as shown in the formula III, so that the technical scheme is more suitable for expanding industrial production.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical synthesis, and specifically, the invention provides a method for purifying an intermediate of iopamidol, which comprises using Lewis soft acid as a catalyst. Background technique

[0002] In the process of medical diagnosis using X-ray fluoroscopy, a considerable part of the human tissue structure cannot be clearly displayed if only relying on their own density and thickness differences, so contrast agents must be introduced to achieve the purpose of clear imaging. Contrast agents can alter the contrast of an organ, injury, or any other surrounding structure, making this detail visible, which in turn can ensure an accurate diagnosis.

[0003] Contrast agents were originally used in the field of radiology or MRI diagnosis. Depending on the field of application, these derivatives exhibit different structural features, for example, in the case of molecules used as contrast agents for X-ray analysis, th...

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