94results about How to "Low hemolysis rate" patented technology

The invention discloses an endotoxin adsorbent used in hemoperfusion, and a preparation method thereof. The preparation method comprises the following steps: a porous carrier is prepared; the carrier is polystyrene divinylbenzene resin or polymethyl methacrylate resin, wherein the pore size of the resin is 5-50nm and the specific surface area of the resin is no less than 500m<2> / g; residual double bonds of the carrier resin are subjected to epoxidation modification; and ligands are immobilized. According to the scheme of the invention, a synthesis process route is changed, such that adsorbent harmful substance residue is avoided, and adsorbent adsorption capacity is improved. Specifically, residual double bonds of the adsorption resin are subjected to epoxidation modification, such that the epoxy group amount is increased; with the epoxy groups, hydrophobic tethers are added, such that ligand movement capacity is improved, and the adsorbent is provided with a good endotoxin adsorption effect; and resin pore size and specific surface area are controlled, such that the adsorption amount and removal rate of the adsorbent upon cytokines are ensured.

The invention provides novel synthesis antibacterial peptides and application thereof. The novel synthesis antibacterial peptides are designed and synthesized on the basis of analyzing sequences and structures of natural antibacterial peptides, and the sequences of the novel synthesis antibacterial peptides comprise WYQ-a: ArgArgTrpTrpArg and WYQ-b: PheArgTrpTrpArg. The synthesis antibacterial peptides have the broad spectrum killing activity on gram-positive bacteria and gram-negative bacteria, have higher bactericidal activity than that of the natural antibacterial peptides, and do not have a toxic effect on animal and plant cells. The synthesis antibacterial peptides have broad antibacterial spectra and simple structures, are not needed to be modified and connected and are convenient to synthesize artificially. Experiments prove that: for G+bacteria (the gram-positive bacteria) and G-bacteria (the gram-negative bacteria), the novel synthesis antibacterial peptides have the obvious bacteriostatic and bactericidal activity and do not have hemolysis activity, so the synthesis antibacterial peptides have significant value in the development and application of antibacterial medicines.

The invention provides an antibacterial peptide and application thereof, and belongs to the technical field of biology. The antibacterial peptide is obtained through rational molecular design on the basis of antibacterial peptide Indolicidin separated from bovine neutrophils; and the antibacterial peptide is antibacterial peptide Indo-1 with the amino acid sequence shown as SEQ ID NO. 1 or antibacterial peptide Indo-2 with the amino acid sequence shown as SEQ ID NO. 2. The antibacterial peptide provided by the invention has good structural characteristics; the antibacterial effect on staphylococcus aureus, salmonella and aspergillus flavus can be obviously improved; and meanwhile, the hemolysis rate and the cytotoxicity of chicken red blood cells can be effectively reduced; the antibacterial peptide can be effectively used in animal-related production activities.

The invention discloses a micromolecule synthesized anti-microbial peptide, as well as a preparation method and application thereof. The sequence of a cationic anti-microbial peptide is SQ1: R-W-W-R-F-NH2 (Arg-Arg-Trp-Trp-Arg-NH2), and the preparation method is the solid-phase chemosynthesis method. The micromolecule synthesized anti-microbial peptide has broad-spectrum cytotoxicity to gram-positive bacteria and gram-negative bacteria, has stronger bactericidal activity than a natural anti-microbial peptide, is simple in structure, convenient for artificial synthesis without any modification and connection, has the advantages of small hemolytic toxicity and no poison effects on animal and plant cells, and has an important value in development and application of antimicrobial agents.

The invention provides a safe blood or blood component storage container and a preparation method thereof. The storage container comprises a storage bag and a tube; wherein, the storage bag is made of a polyurethane / polyvinyl chloride double-layer composite cylinder film; the tube is made of a polyurethane / polyvinyl chloride double-layer composite tube; the inner layer of the polyurethane / polyvinyl chloride double-layer composite cylinder film is made of polyurethane, and the corresponding outer layer thereof is polyvinyl chloride; the inner surface of the polyurethane / polyvinyl chloride double-layer composite tube is a polyurethane layer, and the outer surface thereof is a polyvinyl chloride layer. The polyurethane / polyvinyl chloride double-layer composite cylinder film is prepared by a co-extrusion blow molding method, and the polyurethane / polyvinyl chloride double-layer composite tube is prepared by a co-extrusion method. The storage container has excellent blood compatibility, can avoid micromolecules such as phthalate di (2- ethylhexyl), plasticizer and the like to pollute the blood, meets the requirements of humid hot sterilization on heat resistance, has the advantages of high mechanical strength, easy bonding and low manufacturing cost, and is suitable for high frequency soldering.

The invention belongs to the technical field of membranes, and in particular relates to a modified polyvinylidene fluoride (PVDF) hollow fiber membrane for hematodialysisa, and a preparation method thereof. A PVDF body is modified by using acryloyl morpholine with rejecting performance on protein adsorption and cell adhesion and acrylic acid with high hydrophilic performance to prepare a hollow fiber membrane; the surface of the membrane is subjected to surface modification by L-arginine with an anticoagulation effect; and the anti-pollution performance, the blood compatibility and the anticoagulation performance of the membrane are finally improved, and a modified hollow fiber hemodialysis membrane with high biocompatibility and anticoagulation performance is obtained. The process provided by the invention is simple and can be applied to the field of hemodialysis.

The invention discloses an antibacterial peptide which is obtained by being separated from a Holstein cow spleen and has antibacterial activity, namely a Holstein cow spleen-derived antibacterial peptide, wherein an amino acid sequence of the Holstein cow spleen-derived antibacterial peptide is shown in SEQ ID NO.1. The antibacterial peptide disclosed by the invention is separated from a cow spleen, and the spleen is one of immune organs of an animal and participates blood storage and immunologic processes, so that the antibacterial peptide is extremely low in hemolysis ratio; meanwhile, the antibacterial peptide has some safe biological characteristics without toxic or side effect such as broad antibacterial spectrum, speediness in sterilization, high selectivity, no drug resistance, no teratogenic effect and difficulty in formation of accumulative intoxication, is broad in antibacterial spectrum, has efficient antibacterial effect on Gram negative bacteria, Gram positive bacteria and fungi, can be used for preparing medicines used for treating the Gram negative bacterial, Gram positive bacterial or / and fungal infection and also can be used as a feed additive or a food additive.

The invention provides an anticoagulant and antibacterial indwelling needle sleeve pipe and its preparation method. The anticoagulant and antibacterial indwelling needle sleeve pipe includes an indwelling needle sleeve pipe and an anticoagulant and antibacterial coating grafted on the indwelling needle sleeve pipe through photo initiation. The coating includes heparin sodium and hydrogen abstraction type quaternary ammonium salt with the structure shown in the formula I. A hydrogen extraction and recombination reaction occurs between hydrogen abstraction type quaternary ammonium salt, the surface of an indwelling needle sleeve pipe base body and heparin molecules, the adhesion property of the coating is thus very high, the adhesion stability is good, and the coating has high universality and practicability; the anticoagulant and antibacterial indwelling needle sleeve pipe has non-release type anticoagulant and antibacterial effects, during the sleeve pipe penetration, transfusion, blood flow scouring and other processes, components of the coating are not dissociated and do not come off, the anticoagulant and antibacterial effects are lasting, and the risk that quaternary ammonium salt leached out through dissociation enters veins and thus general toxicity is caused is reduced. The formula I is shown in the description, wherein R is selected from chemical structures (shown in the description) or chemical structures (shown in the description), R1 and R2 are independently selected from H or C1-C4 alkyl groups, R3 is selected from C8-C16 alkyl groups, and X- is selected from Cl-, Br- or I-.

The invention discloses an anticoagulation PVDF flat separation film, also discloses a making method of the anticoagulation PVDF flat separation film, and belongs to the technical field of films. The making method of the anticoagulation PVDF flat separation film comprises the following steps: 1, preparing a polyacrylic acid grafted polyvinylidene fluoride copolymer PVDF-g-PAA; 2, making a PVDF-g-PAA flat separation film; and 3, making an argatroban grafted and modified PVDF-ARG film. A PVDF film is modified by micro-molecular argatroban with a high efficiency anticoagulation effect with acrylic acid as a medium in order to obtain a PVDF separation film material with a good anticoagulation effect. The anticoagulation PVDF flat separation film can obviously prolong the recalcification time of the film, substantially reduces adhesion of platelet erythrocytes on the surface of the film, reduces the hemolysis rate, improves the anticoagulation performance and greatly improves the blood compatibility. The method has the characteristics of simple process and easy industrialization enforcement.

The invention discloses a method for preparing a praseodymium-doped titanium nitride coating on the surface of a medical titanium alloy. The method comprises the following steps: preparing a titanium nitride coating on the surface of the medical titanium alloy by utilizing a magnetron sputtering method; transferring the medical titanium alloy with the titanium nitride coating into a vacuum chamber A of a plasma-immersion-type ion implanter under the condition that a praseodymium target and a sample disk A are respectively arranged at two ends of the inside of the vacuum chamber A; fixing the medical titanium alloy with the titanium nitride coating on the sample disk A; regulating the vacuum degree of the vacuum chamber A under the condition that the praseodymium target is taken as an ion source of a cathode; regulating the rotating speed of the sample disk A and cooling the sample disk A in a water-cooling manner; and then, carrying out praseodymium ion implantation at a room temperature, thereby obtaining the praseodymium-doped titanium nitride coating prepared on the surface of the medical titanium alloy. According to the method disclosed by the invention, the corrosion resistance of the prepared praseodymium-doped titanium nitride coating is obviously superior to that of a common titanium nitride coating; the breeding and the spreading of a large quantity of vascular endothelial cells in the praseodymium-doped titanium nitride coating can be carried out, so that the biological performance of the medical titanium alloy is obviously improved.

The invention discloses a pit-hole composite micro-nano-structure polysaccharide microsphere and a preparation method. The preparation method comprises the following steps: (1) preparing a polysaccharide water solution; (2) adding an emulsifying agent into an oil phase so as to prepare the oil phase containing the emulsifying agent, dropwise adding the polysaccharide water solution into the oil phase containing the emulsifying agent, and stirring for emulsification, so as to obtain a uniform emulsion; (3) dissolving a polyvalent metal cross-linking agent into ultrapure water to prepare a cross-linking agent water solution, dropwise adding the cross-linking agent water solution into the uniform emulsion; and (4) adding n-hexane or petroleum ether into liquid obtained in the step (3), standing until the solution is layered, pouring out an upper oil phase layer, remaining a water phase, cleaning the water phase, and carrying out freeze-drying, so as to obtain the pit-hole composite micro-nano-structure polysaccharide microsphere. The surface of the microsphere is provided with nano-scale pits, and nano-scale fine holes are formed in the surfaces of the pits; the microsphere is uniformin particle size distribution, high in porosity and water absorption rate and strong in adsorbability; and the microsphere has good biocompatibility, and hemostasis can be effectively finished within20s-50s.

The invention provides an embolism microsphere based on soluble starch as well as preparation and application of the embolism microsphere. The embolization microsphere is prepared from soluble starch, an olefin polar monomer, an initiator and a cross-linking agent through a reversed-phase suspension polymerization technology, a continuous phase is an oil phase and a surfactant, and a dispersed phase is the soluble starch, the olefin polar monomer, the initiator and the cross-linking agent. According to the embolism microsphere, the olefin polar monomers and the soluble starch are subjected to free radical grafting and then cross-linking to obtain embolism microspheres, the embolism microspheres are of rich porous structures, pores extend towards the interiors of the microspheres, the specific surface area of the embolism microspheres is large, the surfaces of the embolism microspheres have a large number of hydrophilic polar groups, and the embolism microspheres can generate electrostatic adsorption with drugs, and a good drug sustained-release effect of the embolism microsphere is realized. The doxorubicin hydrochloride drug loading capacity of the embolism microspheres prepared by the method is as high as 191mg / g, the encapsulation efficiency is as high as 96%, and the drug loading capacity and the encapsulation efficiency of the starch embolism microspheres are effectively improved.

The invention provides an antibacterial peptide and application thereof, and belongs to the technical field of biology. The antibacterial peptide is designed and obtained through a rational moleculardesign method on the basis of family analogues Pexiganan of the antibacterial peptide magainin derived from the epithelium of xenopus laevis. The antibacterial peptide is an antibacterial peptide Pexi-1 with an amino acid sequence as shown in SEQ ID NO. 1 or an antibacterial peptide Pexi-2 with an amino acid sequence as shown in SEQ ID NO. 2. The antibacterial peptide provided by the invention hasgood structural characteristics, can significantly improve the antibacterial effect on staphylococcus aureus, salmonella and aspergillus flavus, effectively reduces the hemolysis rate and cytotoxicity of chicken erythrocytes, and can be effectively used in animal-related production activities.

The invention discloses an antibacterial pentapeptide derivative and application thereof. The sequence of the antibacterial pentapeptide derivative is Arg-Arg-Trp-Trp-Arg-beta-phenethylamine. The antibacterial pentapeptide derivative is applied to a medicament for treating or preventing bacterial infection. The bacterium is multi-drug resistant acinetobacter baumannii. The novel antibacterial pentapeptide derivative synthesized by artificial design, provided by the invention, can be conveniently obtained by a solid-phase synthesis method. The synthesized antibacterial peptide has wide spectrum killing activity for gram-positive bacteria and gram-negative bacteria, particularly shows higher antibacterial activity for the multi-drug resistant acinetobacter baumannii, is extremely-low in hemolytic toxicity, and can be applied to medicaments for treating or preventing diseases caused by the multi-drug resistant acinetobacter baumanni.

The invention discloses an application of a pit-hole composite micro-nano-structure polysaccharide micro-sphere to preparation of haemostatic wound dressing. According to GB / T16886.5-2003 in-vitro cytotoxicity judgment standards, acquired pit-hole composite micro-nano-structure polysaccharide micro-sphere extracting solution has 0-grade cytotoxicity under the concentration of 10-40 micrograms / L and shows good biocompatibility, bleeding can be effectively stopped within 20s-50s, good physical and chemical property is achieved, hemolysis ratio is smaller than 5%, national standards are met, themicro-sphere has an instant haemostatic function for a liver injury wound surface (haemostatic time is shorter than 5 seconds), haemostatic materials are completely degraded 72 hours after, and any residue is omitted. The pit-hole composite micro-nano-structure polysaccharide micro-sphere can stop bleeding within 20 seconds when being used for excessive bleeding of a femoral artery, surgical woundsurface recovers normal one week after, and any haemostatic micro-sphere sample residues are omitted.

The invention provides a freeze-dried preparation containing fosaprepitant and a preparation method of the freeze-dried preparation. The freeze-dried preparation contains an active ingredient and other carriers, wherein the active ingredient is an effective amount for treatment of fosaprepitant dimeglumine, and the other carriers include a solubilizing agent, a complexing agent and a freeze-drying excipient; before freeze-drying, an acidity regulator is used for regulating the pH value of a liquid medicine to be 6.5-9.5; and the solubilizing agent is selected from one or more of polyethylene glycol dodecahydroxyl lithium stearate, hydroxypropyl-beta-cyclodextrin and polyethylene glycol. The freeze-dried preparation containing fosaprepitant, provided by the invention, is stable in property and low in hemolysis rate, and improves the compliance of clinical medication of patients.

The invention discloses an antimicrobial hexapeptide. The antimicrobial hexapeptide has a sequence of Arg-Arg-Trp-Trp-Arg-Trp. The antimicrobial hexapeptide can be used in preparation of drugs for treating or preventing bacterial infection. The invention also provides an antimicrobial hexapeptide derivative. The antimicrobial hexapeptide derivative has a sequence of Arg-Arg-Trp-Trp-Arg-Trp-beta-phenylethylamine. The antimicrobial hexapeptide derivative can be used in preparation of drugs for treating or preventing bacterial infection. The bacterium is drug-resistant acinetobacter baumannii. The artificially designed synthetic antimicrobial hexapeptide and its phenylethylamine-modified product can be conveniently obtained by a solid phase synthesis method. The synthetic antimicrobial peptide and its derivative have broad spectrum killing activity to Gram-positive bacteria and Gram-negative bacteria, and particularly, the derivative exhibits stronger antibacterial activity to drug-resistant acinetobacter baumannii, has very small hemolytic toxicity and can be used in drugs for treatment or prevention of diseases caused by drug-resistant acinetobacter baumannii.

The invention discloses a composite material with a rapid blood coagulation effect and a preparation method thereof and belongs to the technical field of biological medicines. The composite material with the rapid blood coagulation effect is prepared from the following raw materials in parts by mass: 8 to 20 parts of chitosan, 7 to 14 parts of salicylaldehyde, 8 to 16 parts of 2-aminoisonicotinic acid, 1.5 to 3.5 parts of ferrous sulfate, 3 to 5 parts of dopa and 10 to 15 parts of disodium hydrogen phosphate. The prepared composite material with the rapid blood coagulation effect has good product stability and high biological safety, has a remarkable effect on blood coagulation, and is simple in process and easy to industrially produce.

The invention relates to a high-plasticity biodegradable Zn-2Li alloy under a GPa-level high-pressure effect and a preparation method thereof. The high-plasticity biodegradable Zn-2Li alloy comprisesthe following components of, by mass, 2% of Li and the balance Zn. The pressure value of the Zn-2Li alloy is the 1 GPa-5 GPa level. The compressive yield strength of the Zn-2Li alloy is 420-550 Mpa, the compressive ultimate strength is 600-800 Mpa, and ductility is 18%-24%. According to the provided preparation method of the high-plasticity biodegradable Zn-2Li alloy under the GPa-level high-pressure effect, more excellent blood compatibility, more excellent mechanical reliability and more excellent abrasion resistance are achieved.

The invention discloses a fat-soluble drug submicron capsule glucose injection and a preparation method thereof. The invention is characterized in that the capsule material comprises the following components in parts by weight: 15-45 parts of sodium alginate, 2.5-9 parts of poloxamer 188, 1.5-5 parts of silk fibroin, 0.5-3 parts of polyvinyl alcohol and 0.2-3 parts of polyethylene glycol. The preparation method comprises the following steps of: sequentially adding the poloxamer, a silk fibroin aqueous solution, a polyvinyl alcohol aqueous solution, the polyethylene glycol and glucose into a sodium alginate aqueous solution at intervals under stirring, and finally dropwise adding a corresponding fat-soluble drug; adopting an ultrasonic and shearing treatment mode; and finally, carrying outfiltration with a 450nm membrane and damp-heat sterilization to obtain the submicron capsule glucose injection. The preparation process of the submicron capsule glucose injection provided by the invention is simple and economic, the particle size of submicron capsules is controllable and uniform, and the biological safety is high.

The invention relates to the technical field of biological engineering, relates to a recombinant human-derived antimicrobial peptide C16LL-37 and an application method thereof in streptococcus mutans bioactivity role, and analysis application of antimicrobial activity, targeting property, hemolytic property and other bioactivities of the recombinant antimicrobial peptide C16LL-37. A standard solid-phase synthesis technique is adopted for synthesis, an amino acid sequence of a human-derived antimicrobial peptide LL-37 is connected with 16 amino acid sequences CSPC16 of a C end of streptococcus mutans CSP through connecting body-GGG-connection, and the recombinant human-derived antimicrobial peptide C16LL-37 having specific targeting ability is synthesized. In conclusion, with research and development of the human-derived specifically targeted antimicrobial peptide C16LL-37, not only are the problems that natural antimicrobial peptides have broad antimicrobial spectra, easy generation of drug resistance, low biological efficiency, high difficulty of screening and the like solved, but also the shortcomings that chemically synthesized antimicrobial peptides have low chemical combination efficiency and fusion proteins are unstable are overcome. In addition, an AMP region of the C16LL-37 is derived from a human body, so the C16LL-37 has relatively high biological safety and lays a firm foundation for wide application in clinic in future.

The invention relates to a nano drug of photoinduced release of nitric oxide anti-biofilm, and a preparation and application method. A synthesis method includes the following steps: (1) performing oxidation co-deposition on acetylglucosamine and dopamine, obtaining glucosamine through deacetylation, and preparing a cationic monosaccharide modified polydopamine nanomaterial (PDG); (2) using the reducibility of an orthophthalic bisphenol structure on the PDG to in situ reduce HAuCl4 into elemental gold nanoparticles, and synthesizing a glucosamine modified polydopamine@gold hybrid nanomaterial (PDG@Au); (3) blending an NO donor TCF and the PDG@Au in a glass sample bottle, and obtaining a PDG@Au-NO nanomaterial through magnetic stirring and centrifugal washing; and (4) modifying diblock copolymer p(AM-b-APBA) prepared from monomer N-3-acrylamide phenyl boric acid (APBA) and monomer4-acryloyl morpholine (AMP) through RAFT polymerization on a surface of the PDG@Au, and preparing PDG@Au / PBA. The nanomaterial obtained by the synthesis method has a good antibacterial effect and an effect of dissipating biofilm.

The invention discloses an adsorption material, which comprises adsorption resin microspheres, wherein ginsenoside is immobilized on the adsorption resin microspheres, the adsorption resin microspheres are of a porous structure, and the average pore diameter of the adsorption resin microspheres is 3-20 nm. The preparation method of the adsorption material comprises the following steps: synthesizing adsorption resin microspheres; modifying the adsorption resin microspheres, wherein the modification mode is double-bond epoxidation modification or benzene ring chloromethylation modification; and immobilizing ginsenoside. According to the invention, by immobilizing ginsenoside on the adsorption resin microspheres, the aperture structure of the adsorption resin microspheres is matched with the molecular size of a target adsorption chemotherapeutic drug so as to achieve the relative specific adsorption capacity of the adsorption resin microspheres to the chemotherapeutic drug, and the ginsenoside has an antibacterial effect, so that the risk of blood-borne infection can be reduced, and the application safety of the ginsenoside in the field of blood purification can be improved; and the adsorption material disclosed by the invention, the adsorption removal rate of chemotherapeutic drugs reaches 90% or above, and the hemolysis rate is less than 5%.

The invention relates to a sulfonated silk fibroin film modified polytetrafluoroethylene artificial blood vessel and a method for preparing the same.The method includes steps of carrying out low-temperature plasma surface pre-treatment on a polytetrafluoroethylene artificial blood vessel, vertically or obliquely arranging the polytetrafluoroethylene artificial blood vessel, sealing one end of the polytetrafluoroethylene artificial blood vessel, forming an opening in the other end of the polytetrafluoroethylene artificial blood vessel, keeping the opening upwards, injecting 0.5-2.0 mg / mL silk fibroin solution into the polytetrafluoroethylene artificial blood vessel from the opening, evaporating the silk fibroin solution and coating the silk fibroin solution in the polytetrafluoroethylene artificial blood vessel; turning the polytetrafluoroethylene artificial blood vessel over, keeping the opening upwards, injecting 0.5-2.0 mg / mL silk fibroin solution into the polytetrafluoroethylene artificial blood vessel from the opening, evaporating the silk fibroin solution and coating the silk fibroin solution in the polytetrafluoroethylene artificial blood vessel to obtain a silk fibroin film modified polytetrafluoroethylene artificial blood vessel, and carrying out low-temperature plasma surface sulfonation treatment on the silk fibroin film modified polytetrafluoroethylene artificial blood vessel to obtain the sulfonated silk fibroin film modified polytetrafluoroethylene artificial blood vessel.The sulfonated silk fibroin film modified polytetrafluoroethylene artificial blood vessel and the method have the advantages that the sulfonated silk fibroin film modified polytetrafluoroethylene artificial blood vessel prepared by the aid of the method is good in uniformity and excellent in blood and tissue compatibility and rarely has chap and crack.

The invention relates to an antibacterial peptide with antibacterial activity separated from cow blood, a code sequence and an application thereof. The antibacterial peptide has 1 to 25 amino acid sequences in a sequence table SEQ ID NO: 1.Except for the common property of the common antibacterial peptide such as wide antibacterial spectrum, quick sterilization, high selectivity, no drug resistance generation and no teratogenic action, the antibacterial peptide also has the flowing advantages that the structure is simple; the artificial synthesis is convenient; no antigenicity exists when theantibacterial peptide is applied to mammals; the antibacterial peptide is separated from the red blood cell of the cow blood; and the red blood cell is one of animal blood components, is involved in the process of blood circulation, and has no hemolytic toxicity or low hemolysis rate. The antibacterial peptide not only can be used for preparing a medicament for treating gram positive bacteria, gram negative bacteria, and epiphyte or viral infection, but also can be applied to the fields such as milk fresh-keeping, or other food preservatives, feed mould inhibitors and the like.

The invention provides an anti-cancer drug, an anti-cancer drug composition, and a preparation method and application thereof. The anti-cancer drug comprises 2-amino-5-[(5-nitro-2-thiazolyl) thio]-1, 3, 4-thiadiazole. The anti-cancer drug composition comprises 2-amino-5-[(5-nitro-2-thiazolyl) thio]-1, 3, 4-thiadiazole and phenylboronic acid polymer. The 2-amino-5-[(5-nitro-2-thiazolyl) thio] -1, 3, 4-thiadiazole has broad-spectrum anticancer property, has obvious inhibiting effect on various cancers, and has lower toxicity to normal cells than cancer cells. The small molecule has simple structure and low hemolysis rate. The phenylboronic acid polymer in the anti-cancer drug composition is used as an auxiliary material, and is combined with the anti-cancer drug through donor-receptor interaction to help deliver the drug into cells; and the phenylboronic acid is sensitive to excessive active oxygen generated in cancer cells, and the excessive active oxygen can selectively release the drug, thereby enhancing the anticancer effect.

The invention relates to a method for preparing immune adjuvant soybean saponin lipotropy derivatives with enhanced activity. The method comprises the following steps: preparing a target product from high-purity soyasaponin Ab, a carbon imine reagent and lauryl amine; detecting the target product by adopting analytical type high performance liquid chromatography (HPLC) and personal digital assistant (PDA) detectors and an evaporative light scattering detector (ELSD); identifying the molecular weight of the target product by using electrospray ionization-mass spectrometry (ESI-MS); carrying out purification and separation by adopting preparative liquid chromatography, so as to obtain lipotropy derivatives AbD of lauryl amine; and analyzing the structure of the target product by adopting nuclear magnetic resonance (NMR). Compared with the prior art, a high-purity modifier AbD is prepared by adopting the method, the molecular weight of the target product is 1603, the yield is 6.94%, the hemolysis ratio is low, the immune adjuvant soybean saponin lipotropy derivatives have potentiation on in vitro immunization of spleen lymphocytes in mice, and meanwhile, the level of four specific antibodies in OVA immune serum in mice is improved.

The invention discloses a digestive tract mucous membrane promotion material. The digestive tract mucous membrane promotion material is prepared by crosslinking genipin and small intestinal submucosa, and the crosslinking index of the small intestinal submucosa crosslinked by genipin is 30-100%. The invention also discloses a preparation method and a use of the digestive tract mucous membrane restoration promotion material. The digestive tract mucous membrane restoration promotion material has the advantages of good acid and pepsin degradation resistance, low hemolytic property, no cytotoxicity and excellent mechanical properties.

The invention discloses a halamine modified xanthan gum / chitosan composite antibacterial dressing and a preparation method thereof, and belongs to the technical field of medical treatment. The preparation method comprises the following steps: combining two biopolymer materials of xanthan gum and chitosan, firstly, carrying out a grafting reaction on a halamine compound precursor 3-(2 '-chloroethyl)-5, 5-dimethyl hydantoin (CEDMH) and xanthan gum (XG), and matching with organic chlorination to prepare an antibacterial agent XG / CEDMH-Cl, the molar ratio of xanthan gum to 3-(2'-chloroethyl)-5, 5-dimethyl hydantoin (CEDMH) being 1: (1-6); then compounding chitosan (CS) and XG / CEDMH-Cl to prepare a polyelectrolyte complex, adding glycerol at the same time, and drying the product to obtain XG / CEDMH-Cl&CS composite antibacterial dressing, wherein the mass ratio of chitosan to XG / CEDMH-Cl is (1-5): 1. The composite antibacterial dressing obtained by the preparation method has a good antibacterial effect and good biocompatibility.