Use of material prepared through cross-linking genipin to intestinal mucosal lower layer

A small intestinal submucosa, genipin technology, applied in medical science, prosthesis, etc., can solve the problems of easy premature degradation, low friction coefficient, difficult SIS, etc., and achieves no cytotoxicity, excellent mechanical properties, and suitable pore size. Effect

Active Publication Date: 2015-11-18
TOPREGMED BEIJING MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some obvious defects in using SIS as a repair material for the digestive tract mucosa, such as being easily deformed in contact with water, easily degraded by strong acid and pepsin, and having a low coefficient of friction, which makes it difficult to transport SIS endoscopically and is easy to reach the lesion. Loss of function due to premature degradation

Method used

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  • Use of material prepared through cross-linking genipin to intestinal mucosal lower layer
  • Use of material prepared through cross-linking genipin to intestinal mucosal lower layer
  • Use of material prepared through cross-linking genipin to intestinal mucosal lower layer

Examples

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Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1 The preparation of the material for promoting the repair of digestive tract mucosa of the present invention

[0044] 1. The preparation of the material for promoting digestive tract mucosa repair of the present invention

[0045] 1. Preparation of SIS

[0046] The SIS of the present invention can be purchased as a commercial product, or can be prepared according to the following method.

[0047] (1) Cleaning and finishing: Take the fresh pig small intestine half an hour after slaughter, wash away the contents of the small intestine with water, turn over the small intestine, add salt and rub it, rinse it with water three times, cut open the small intestine with a scalpel, and then cut it into 15 cm long of the intestinal segment.

[0048] (2) Isolation of SIS: the muscle layer and serosa layer were scraped off with a spatula, and stored in normal saline at 4°C overnight.

[0049] (3) Degreasing: Rinse with deionized water and drain the water with gauze. ...

Embodiment 2

[0083] Example 2 Preparation of the material for promoting digestive tract mucosa repair of the present invention

[0084] 1. The preparation of the material for promoting digestive tract mucosa repair of the present invention

[0085] 1. Preparation of SIS

[0086] The SIS of the present invention can be purchased as a commercial product, or can be prepared according to the following method.

[0087](1) Cleaning and finishing: Take the fresh pig small intestine half an hour after slaughter, wash away the contents of the small intestine with water, turn over the small intestine, add salt and rub it, rinse it with water three times, cut open the small intestine with a scalpel, and then cut it into 15 cm long of the intestinal segment.

[0088] (2) Isolation of SIS: the muscle layer and serosa layer were scraped off with a spatula, and stored in normal saline at 4°C overnight.

[0089] (3) Degreasing: Rinse with deionized water and drain the water with gauze. Immerse in the ...

Embodiment 3

[0099] Example 3 The preparation of the material for promoting the repair of digestive tract mucosa of the present invention

[0100] 1. The preparation of the material for promoting digestive tract mucosa repair of the present invention

[0101] 1. Preparation of SIS

[0102] The SIS of the present invention can be purchased as a commercial product, or can be prepared according to the following method.

[0103] (1) Cleaning and finishing: Take the fresh pig small intestine half an hour after slaughter, wash away the contents of the small intestine with water, turn over the small intestine, add salt and rub it, rinse it with water three times, cut open the small intestine with a scalpel, and then cut it into 15 cm long of the intestinal segment.

[0104] (2) Isolation of SIS: the muscle layer and serosa layer were scraped off with a spatula, and stored in normal saline at 4°C overnight.

[0105] (3) Degreasing: Rinse with deionized water and drain the water with gauze. Imm...

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Abstract

The invention discloses a digestive tract mucous membrane promotion material. The digestive tract mucous membrane promotion material is prepared by crosslinking genipin and small intestinal submucosa, and the crosslinking index of the small intestinal submucosa crosslinked by genipin is 30-100%. The invention also discloses a preparation method and a use of the digestive tract mucous membrane restoration promotion material. The digestive tract mucous membrane restoration promotion material has the advantages of good acid and pepsin degradation resistance, low hemolytic property, no cytotoxicity and excellent mechanical properties.

Description

[0001] This application is a divisional application of the patent application with the filing date: April 10, 2014, the application number: 201410143074.0, and the title of the invention: a material for promoting digestive tract mucosa repair and its preparation method and use. technical field [0002] The invention relates to the application of the material prepared by cross-linking small intestinal submucosa with genipin. Background technique [0003] Peptic ulcers mainly refer to chronic ulcers that occur in the stomach and duodenum, and can also occur in the lower segment of the esophagus, around the gastrojejunostomy and Meckel’s diverticulum containing ectopic gastric mucosa. The formation of these ulcers is related to Gastric acid is related to the digestion of pepsin, so it is called peptic ulcer. Peptic ulcer is one of the common clinical diseases of the digestive system. In recent years, with the acceleration of the pace of life, changes in diet structure and irreg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/36A61L27/50
Inventor 解慧琪王旻
Owner TOPREGMED BEIJING MEDICAL TECH CO LTD
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