82 results about "Genipinine" patented technology

The invention belongs to the field of medicines and particularly relates to a new application of an iridoid glycoside compound, genipin-1-[beta]-D-gentiobioside, and a composition composed by compounding the genipin-1-[beta]-Dgentiobioside with other components as effective components for preparing antiviral drugs, antibacterial drugs, fever alleviating drugs, inflammation resistant drugs and anti-oxidizing drugs. The iridoid glycoside compound and the composition can be used for treating acute respiratory infection, flu, pneumonia, viral hepatitis type B, herpes zoster, herpes viral keratitis, viral myocarditis, Epstein-Barr virus infection, retrovirus infectious diseases and bacterial infectious diseases.

The invention discloses a geniposide-rich hydrophilic molecularly imprinted polymer, a preparation method and application, and belongs to the technical field of separation. Template geniposide, an alkenyl glucoside functional monomer, a cross-linking agent, an initiator and an pore-forming agent are added in an aqueous solvent system, the alkenyl glucoside functional monomer and the template molecule form a non-covalent template-monomer complex through invertible self-assembly, the template geniposide is removed, and the geniposide-rich hydrophilic molecularly imprinted polymer is obtained. The alkenyl glucoside functional monomer is used for the first time to prepare the geniposide molecularly imprinted polymer in the water phase; compared with a traditional molecularly imprinted polymer prepared from a liposoluble functional monomer, the polymer prepared in the water phase has good hydrophilia, and has better adsorption performance in a water medium.

The invention discloses an application of geniposide which is used as an acetylcholin esterase inhibitor in a medicament for treating and preventing diseases with acetylcholin esterase activity abnormity. The invention relates to geniposide which directly inhibits activity of the acetylcholin esterase, inhibits activity of acetylcholin esterase in a cultured nerve cell, and inhibits activity of the acetylcholin esterase in a transgenic animal brain with Alzheimer's disease. The geniposide can bring inhibition effect on the activity of the acetylcholin esterase into play by virtue of the way, but is not limited to the way, and the geniposide possibly has a potential treatment value on the Alzheimer's disease by inhibiting the acetylcholin esterase.

The invention discloses a beta-glucosidase high-yielding strain. The beta-glucosidase high-yielding strain is screened from the nature, with fructus gardenia as a carbon source, and has a preservation number of CCTCC No.M2013634 and is classified and named as penicillium rolfsii HXL; the strain is able to efficiently convert geniposide and polydatin into genipin and resveratrol; on that basis, a method for converting and preparing genipin and resveratrol by using the beta-glucosidase high-yielding strain above is created. The method has the advantages that geniposide and polydatin are respectively hydrolyzed under a mild condition, so as to avoid the shortage of the loss of active ingredients of the traditional method, and thus the yield is effectively increased; in addition, the active ingredients, namely, geniposide or polydatin, of fructus gardenia or polygonum cuspidatum are converted by mass under an in-vitro controllable condition by the modern microbial fermentation engineering technology and enzyme engineering technology, and thus the production cost is decreased, and the production efficiency is improved. With the adoption of the beta-glucosidase high-yielding strain, a feasible manner is provided for industrially producing beta-glucosidase, genipin and resveratrol as mass, large economic benefit and social benefit are brought, and the market development prospect is wide.

The invention discloses a method for extracting aucubin and geniposide from eucommia ulmoides peel at the same time. The method includes the steps of firstly, weighing aucubin, geniposide and cobaltous acetate to be dissolved in an acetonitrile-dimethyl sulfoxide mixed solution according to a certain proportion, conducting shaking, adding functional monomers to be shaken, adding mixed cross-linking agent TRIM-DVB and initiator AIBN to be sufficiently mixed, transferring the mixture into a round-bottom flask, and conducting degassing, argon introducing and bottle sealing; secondly, putting the mixture in a constant-temperature water bath kettle at the temperature of 60 DEG C to be subjected to a polymerization reaction, and conducting smashing, screening, depositing, filtering, eluting and vacuum drying; thirdly, putting obtained molecularly imprinted polymers into a solid-phase extraction cylinder, conducting washing and eluting after sample adding, and obtaining aucubin and geniposide. Through the metal ion coordination imprinting technology, binary compound metal ion complex serves as a template molecule, molecule imprinting polymers with high selection recognition performance is synthesized, and quite high practical value is achieved when aucubin and geniposide are extracted from eucommia ulmoides peel at the same time through the polymers.

The present invention discloses one kind of total jasminoidin extract and features that the total jasminoidin extract contains jasminoidin 45-90 wt%, genipin-1-beta-D-gentiobioside 5-30 wt% and jasminoidin + genipin-1-beta-D-gentiobioside 50-100 wt% and preferably contains jasminoidin 50-80 wt%, genipin-1-beta-D-gentiobioside 5-25 wt% and jasminoidin + genipin-1-beta-D-gentiobioside 55-100 wt%. Pharmacological experiment shows that the total jasminoidin extract of the present invention has excellent pharmacological effect.

A temporary tattooing ink is produced from concentrated genipin. In one embodiment, the concentrated genipin forms part of a solution. In another embodiment, the genipin is provided in a gel form which also includes a solvent and a thickening agent. Finally, an applicator is described into which genipin may be embedded for applying to a user's skin.

The invention discloses application of a genipin amino acid derivative as an NF-kappa B (nuclear transcription factor kappa-B) inhibitor. The genipin amino acid derivative as the NF-kappa B inhibitor controls the expression of various inflammatory cytokines, major histocompatibility composite gene and adhesion molecules, which participate in the tumor metastasis, and restrains and treats pathological symptoms caused by NF-kappa B activation by blocking the nuclear factor NF-kappa B activation, wherein the symptoms include cancer, autoimmune diseases (such as rheumatoid arthritis), cardiovascnlar and cerebrovascular diseases, acute and chronic inflammations, nervous system disorders (depression, Alzheimer's disease, etc.). The genipin amino acid derivative can restrain the NF-kappa B activity in a dose and time-dependent manner. The invention provides a novel drug source for NF-kappa B inhibitors and NF-kappa B control related diseases.

The invention discloses an application of geniposide in preparation of medicines for treating and preventing a radioactive lung injury caused by ionizing radiations. The geniposide as the medicines for treating and preventing the radioactive lung injury caused by aerospace, nuclear radiation and thoracic cancer radiotherapy strengthens the immunity of the organism to alleviate the radiation injury, so that the geniposide can provide a selective radiation protection idea for the radioactive lung injury caused by ionizing radiations, including an aerospace business, a nucleus scientific and technological development and a breast cancer radiotherapy and the like.

The invention discloses application of a beautifying cornea lens, and aims at applying the beautifying cornea lens to repairing the damage of cornea tissues, improving the appearance of an ocular surface, curing visual symptoms such as photophoby, glaring, diplopia and the like resulting from iris abnormity, or being used as a covering sheet or a medicine carrier for protecting the cornea in an ophthalmic operation, wherein the beautifying cornea lens is prepared in a way that: a biological material rich in amino is added into a solution containing genipin or genipin derivatives, the genipin is taken as a cross-linking agent to conduct the contact reaction, and then the mixture is rinsed, frozen and dried to prepare the beautifying cornea lens. The beautifying cornea lens provided by the invention can be used for repairing the damage of the cornea tissues, improving the appearance of the ocular surface, curing the visual symptoms such as photophoby, glaring, diplopia and the like resulting from iris abnormity, or being used as the covering sheet or the medicine carrier for protecting the cornea in the ophthalmic operation, therefore, a new approach is directly explored for clinical application.

The invention belongs to the field of compound synthesis, and particularly relates to a geniposide derivative with xanthine oxidase inhibitory activity as well as a preparation method and application of the geniposide derivative. The geniposide derivative has a molecular structure shown in the specification. According to the invention, a novel geniposide derivative is synthesized, and the geniposide derivative has an obvious effect of inhibiting the activity of xanthine oxidase; the geniposide is subjected to structural modification, so that the biological activity of the geniposide can be greatly improved, and the geniposide has important practical significance on research and development of novel uric acid reducing drugs; according to the geniposide derivative with the xanthine oxidase inhibitory activity, related structural modification is carried out by taking geniposide as a raw material, the synthesis method is simple, the raw material price is low, and the structure is novel.

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a composition containing pinoresinol diglucoside and genipin and application thereof. The composition containing pinoresinol diglucoside and genipin is prepared from the following components: pinoresinol diglucoside, genipin, nicotinamide, quercetin, a radix achyranthis bidentatae extract, tartronic acid and citric acid. The composition is simple in preparation method, can be used for treating hypertensive nephropathy, has a good curative effect, and can reduce side effects and reduce cost.

The invention relates to a preparation method and application of a novel modified egg white cell culture scaffold material. The method includes: step one, adding genipin into sterile ultrapure water, stirring, oscillating ultrasonically and completely, thoroughly dissolving at 25-40 DEG C, adding 0.2ml of the genipin solution into a reaction vessel containing 2ml of fresh egg white, and well mixing; step two, putting the egg white with the genipin serving as a crosslinking agent into a thermostat to realize complete crosslinking; step three, using a pipette for dripping a modified egg white cell culture scaffold material obtained at the step two into a PBS solution drop by drop to guarantee immersion of materials without overflowing, standing for more than 12 hours to remove surplus genipin molecules, and repeating for several times; step four, putting a modified egg white cell culture scaffold material obtained after reaction on a cell clean bench, and performing ultraviolet radiation for sterilization to obtain the novel modified egg white cell culture scaffold material. The hardness gradient of the novel modified egg white cell culture scaffold material is easy to control, and safety and avoidance of toxic and side effects are realized.

The invention provides application of geniposide in preparation of a medicine for treating asthenospermia. Experimental results show that the geniposide can significantly improve the sperm quantity and activity and reduce the sperm malformation rate, can significantly inhibit endoplasmic reticulum stress inside testis, increase mitochondrial membrane potential, regulate expression of related proteins in testis tissues, and improve excessive apoptosis of spermatogenic cells.

The invention provides novel genipin derivatives and a preparation method thereof. The novel genipin derivatives comprise geniposide derivatives and genipin derivatives. The invention belongs to the field of pharmaceutical chemistry. The geniposide derivative has a structure shown as a formula (I).

The invention belongs to the technical field of preparation of novel compounds, and particularly relates to an amide pentaacetyl geniposide derivative as well as a preparation method and application thereof. The amide penta-acetyl geniposide derivative provided by the invention is prepared by the following steps: firstly, hydrolyzing lipid groups at C-4 sites of iridoid in geniposide to obtain geniposidic acid, then acetylating five hydroxyl groups at 2 ', 3', 4 ', 6' and 11 sites on sugar to obtain penta-acetyl geniposidic acid (2a), and finally reacting with RNH2 to obtain the penta-acetyl geniposide derivative. The geniposide derivative prepared by the invention has remarkable XOD inhibitory activity and kidney injury improvement activity, and can effectively reduce the accumulation of uric acid in the kidney. The inflammatory reaction is reduced, so that the level of inflammatory factors is reduced; renal fibrosis of a mouse with hyperuricemia can be reduced by inhibiting expression of an inflammatory factor TGF-beta.

The invention belongs to the technical field of novel compound preparation, and particularly relates to an ester pentaacetyl geniposide derivative obtained through esterification reaction and a preparation method and application thereof. The amide penta-acetyl geniposide derivative provided by the invention is prepared by the following steps: firstly, hydrolyzing lipid groups at C-4 sites of iridoid in geniposide to obtain geniposidic acid, then acetylating five hydroxyl groups at 2 ', 3', 4 ', 6' and 11 sites on sugar to obtain penta-acetyl geniposidic acid (2a), and finally reacting with ROH to obtain the penta-acetyl geniposide derivative. The geniposide derivative prepared by the invention has remarkable XOD inhibitory activity and kidney injury improvement activity, and can effectively reduce the accumulation of uric acid in the kidney. The inflammatory reaction is reduced, so that the level of inflammatory factors is reduced; renal fibrosis of a mouse with hyperuricemia can be reduced by inhibiting expression of an inflammatory factor TGF-beta.

A calcium alginate hydrogel film has good anti-pollution performance and molecular interception performance. However, the calcium alginate hydrogel is poor in stability and mechanical strength in a high-salinity aqueous solution. The invention discloses an oxalic acid and genipin cross-linked hydrogel filter membrane and application of the oxalic acid and genipin cross-linked hydrogel filter membrane in molecular ion separation under high salinity. The method comprises the following steps: preparing a mixture aqueous solution of sodium alginate and a polymer reinforcing agent as a membrane casting solution, scraping the membrane casting solution to form a membrane, and conducting crosslinking with oxalic acid and a genipin aqueous solution. Oxalic acid is simultaneously crosslinked with hydroxyl on the polymer reinforcing agent and hydroxyl on the alginate, and genipin is crosslinked with hydroxyl on the polymer reinforcing agent, amino and hydroxyl on the alginate. The obtained oxalicacid and genipin cross-linked hydrogel filter membrane can tolerate a high-concentration inorganic salt solution. The filter membrane has a low rejection rate on inorganic salt, has a high rejectionrate on body type molecules with the molecular weight of more than 650, and is particularly suitable for separation of molecular ions under high salinity.