13 results about "Genipinine" patented technology

The invention is applicable to the technical field of biomedicine, and provides dipeptide-photosensitizer molecule co-assembled nanoparticles as well as a preparation method and application thereof. According to the invention, cationic diphenylalanine (CDP) and a biological cross-linking agent genipin are self-assembled to form a dipeptide carrier, and then the dipeptide carrier and a photosensitizer molecule chlorin e6 (Ce6) are co-assembled, so that nanoparticles with controllable size, controllable drug loading capacity and good biocompatibility are successfully prepared. The preparation method is simple and easy to implement, effectively solves the key problems that the traditional photosensitizer molecule Ce6 is poor in biocompatibility and easy to gather, not only can efficiently deliver Ce6, but also obviously improves the application safety and biocompatibility of Ce6. The Ce6 is almost free of dark toxicity under a dark condition, can play a strong photodynamic killing role under illumination, and greatly improves the possibility and application potential of the Ce6 in tumor photodynamic therapy by virtue of the flexible regulation and control advantages of the size and the drug loading capacity.

The present invention discloses use of a male flower extract of Eucommia ulmoides Oliver in preparation of a food or a medicament for resisting muscle aging, belonging to the technical field of plant extracts. A main active ingredient of the male flower extract of Eucommia ulmoides Oliver is iridoids, and the composition of the iridoids includes aucubin, geniposide, geniposidic acid and asperuloside. The present invention reports for the first time that the male flower extract of Eucommia ulmoides Oliver and the iridoids contained therein have mitophagy activation activity and maintain normal mitochondrial function by effectively stimulating mitophagy. The extract has a relatively strong ability to prevent or alleviate aging-related muscle hypofunction, and has great application prospects in food, pharmaceutical and other fields.

A stabilized blue colorant is disclosed. The colorant includes a population of amino-acid-substituted genipin polymers having exclusively leucine, lysine, and arginine substitutions. The population includes a relative amino acid distribution of 5-90%leucine, 5-90%lysine, and 5-90%arginine. The stabilized blue colorant retains its blue color better than existing options. The colorant is made by a process that includes reacting genipin with the specific amino acids identified.

The application discloses a capillary electrophoresis quantitative analysis method of active ingredients of Wuobi Shanyao pills. The method comprises the following steps: pretreating and purifying the powder of the test sample Wuobi Shanyao pills by MSPD-SPE, and quantitatively determining the active ingredients of the test sample, i.e., loganin, geniposidic acid, trilobatin and verbascoside by CE-UV. The MSPD with high extraction efficiency, the SPE with strong purification capacity and the CE with less consumption of organic solvents are combined for the first time, and are used for green, efficient and accurate content determination of the four components (loganin, geniposidic acid, trilobatin and verbascoside) in Wuobi Shanyao pills. In the sample preparation process and in the CE separation and determination, the consumption of organic solvents is far less than the amount consumed in the prior art.

The invention belongs to the field of preparation of functional compounds, and particularly relates to a genipin derivative with an amino ether structure, a preparation method of the genipin derivative and application of the genipin derivative to reduction of uric acid. The genipin derivative is designed and synthesized by taking genipin as a lead compound and carrying out chemical modification on the genipin. In order to enhance the binding capacity of the genipin derivative and XOD, the C-14 site of genipin ether is substituted, an aromatic ring or aromatic heterocyclic group containing organic amine is introduced, and the chemical structure of the obtained genipin derivative is represented and confirmed through 1H NMR and 13C NMR. The geniposide derivative synthesized by the invention is subjected to XOD inhibitory activity screening. The invention provides a structural and theoretical basis for subsequent further research on a more efficient XOD inhibitor.

The application provides a genipin cross-linked selenium nanoparticle and a preparation method and application thereof, and belongs to the field of functional nanomaterials and intelligent nutrition delivery technology. The preparation method comprises the following steps: dissolving a protein substance in water to obtain a protein solution, adding a selenous acid compound, then adding vitamin C and genipin, performing cross-linking reaction, and performing dialysis on the obtained reaction solution to obtain the genipin cross-linked selenium nanoparticle. The application innovatively uses the concentration of genipin as a control switch, realizes active and accurate control of the release rate of selenium in the intestinal tract, realizes the treatment effect on colitis through instantaneous high-concentration release under a low-concentration selenium administration dose, and effectively solves the defect that the "nutrition-toxicity" dose range of selenium is narrow.

Use of genipin-1-β-D gentiobioside in the preparation of a drug for treating chronic obstructive pulmonary disease. Genipin-1-β-D gentiobioside is prepared into a solution for atomized inhalation. Using the administration mode of atomized inhalation can improve lung function in chronic obstructive pulmonary disease, reduce the content of inflammatory factors in lung tissue, and reduce damage to lung tissue.

The invention belongs to the field of preparation of functional compounds, and particularly relates to a methylated aromatic substituted genipin derivative with a uric acid reducing effect as well as a preparation method and application of the methylated aromatic substituted genipin derivative. The genipin derivative synthesized by the invention is subjected to XOD inhibitory activity screening, and researches on in-vivo and in-vitro activity, uric acid reduction and XOD inhibitory activity, anti-inflammatory activity and anti-fibrosis activity show that the derivative shows relatively high XOD inhibitory activity; oxidative stress is relieved by inhibiting XOD activity at the liver, so that liver inflammation is inhibited. The invention provides a structural and theoretical basis for subsequent further research on a more efficient XOD inhibitor.

According to the oleic acid-geniposide composite preparation and the application thereof, a mixed system of oleic acid and geniposide is constructed and acts on PC12 cells induced by hydrogen peroxide to generate oxidative damage, and the result shows that compared with cells treated by singly using geniposide with the same concentration, the oleic acid-geniposide composite preparation has the advantages that the effect is good, and the cost is low. The mixed system can obviously improve the survival rate of PC12 cells, and the obvious effect is not observed after linoleic acid and linolenic acid are respectively mixed with geniposide. The invention clarifies that oleic acid can enhance the protective effect of geniposide on oxidative damage cells, and provides a brand new thought and technical support for developing products for resisting oxidative damage of cells.

The present application relates to topical compositions comprising a compound capable of covalently binding to the skin and an excipient suitable for topical application wherein the compound capable of covalently binding to the skin is a compound of formula (I) or a tautomer and / or a pharmaceutically acceptable salt thereof, wherein R1 represents hydrogen or a protecting group that is hydrolysable under physiological conditions upon application of the topical composition to the skin; wherein L1, L2 and L3, independently of each other, represent a linking group or are absent, and wherein A1, A2 and A3, independently of each other, represent: a) a C1-C30 moiety, H, hydroxyl, amino or halogen, or b) a C1-C60 moiety or a polymeric moiety; wherein at least one of A1, A2 and A3 is a C1-C60 moiety or a polymeric moiety of group b); wherein the C1-C60 portion or polymeric portion of group b): b1) is configured to act as a skin moisturizer, an insecticide, a skin whitening agent or a drug; and / or b2) is configured to act as a skin moisturizer, an insecticide, a skin whitening agent, a fragrance or a drug upon cleavage from the 3, 4-dihydro-2H-pyran moiety; and wherein L1-A1 and L2-A2 do not represent a moiety comprising an unsaturated C-C or C-N bond at the alpha position of the carbon atoms marked as "a" and "b", respectively. (I);

The invention relates to the technical field of medical materials, in particular to a coloring agent for endoscopic surgery and a preparation method and application thereof.The coloring agent is an acetyl-GPLGIRG-genipin enzyme activated precursor, the acetyl-GPLGIRG-genipin enzyme activated precursor is obtained through a reaction of acetylated GPLGIRG polypeptide and genipin, and the GPLGIRG polypeptide and the genipin are used for preparing the coloring agent for endoscopic surgery. The genipin is connected to the carbon end of the acetylated GPLGIRG polypeptide. Rapid, clear and lasting targeted blue labeling of a lesion area is realized by using a specific cross-linking reaction of a genipin component and a protein amino group and utilizing biochemical difference of a lesion tissue and a normal tissue on a microstructure. The problem that a traditional staining agent cannot specifically mark lesions is solved, a pad formed by lifting liquid under mucous membranes is more stable and durable due to the cross-linking characteristic of the staining agent, and double advantages are provided for endoscopic surgery.

This invention relates to the field of cellular drug screening technology, specifically to a genipin derivative, its synthesis method, and its uses. The genipin derivative is an N-substituted genipin lactam derivative or a cyclopentenepyridine derivative; the N-substituted genipin lactam derivative is a compound represented by general formula (I), and the cyclopentenepyridine derivative is a compound represented by general formula (II); wherein R is selected from any one of hydrogen, alkyl, phenyl, and aralkyl. This invention uses genipin as a lead compound, modifies the core structure, and performs cellular activity screening to identify lead compounds with good activity and low toxicity, providing a foundation for subsequent research on the anti-inflammatory effects of genipin.

The invention provides genipin cross-linked selenium nano-particles and a preparation method and application thereof, and belongs to the technical field of functional nano-materials and intelligent nutrition delivery, the preparation method comprises the following steps: dissolving a protein substance in water, hydrating to obtain a protein solution, adding a seleninic acid compound, then adding vitamin C and genipin, and uniformly stirring to obtain the genipin cross-linked selenium nano-particles. And carrying out a cross-linking reaction, and dialyzing the obtained reaction liquid to obtain the genipin cross-linked selenium nanoparticles. The genipin concentration is innovatively used as a regulation switch, active and accurate control over the release rate of selenium in the intestinal tract is achieved, namely, the treatment effect on colitis can be achieved through instant high-concentration release under the condition of the low-concentration selenium administration dosage, and the defect that the nutrition-toxicity dosage range of selenium is narrow is effectively overcome.