Haloamine modified xanthan gum/chitosan composite antibacterial dressing and preparation method thereof

A technology of compounding antibacterial and xanthan gum, applied in the medical field, can solve the problems of easy dissolution of antibacterial agents and low antibacterial efficiency, and achieve the effect of good antibacterial performance and good safety.

Active Publication Date: 2021-07-02
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, antibacterial dressings have the following problems: (1) The antibacterial efficiency is low. The antibacterial agent used in antibacterial dressings is generally nano-silver. -80%; (2) The antibacterial agent is easy to dissolve, and the antibacterial dressing prepared by physical deposition, surface adsorption, etc., the antibacterial agent is easy to dissolve, and there are potential safety hazards

Method used

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  • Haloamine modified xanthan gum/chitosan composite antibacterial dressing and preparation method thereof
  • Haloamine modified xanthan gum/chitosan composite antibacterial dressing and preparation method thereof
  • Haloamine modified xanthan gum/chitosan composite antibacterial dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] A method for preparing haloamine modified xanthan gum antibacterial agent, comprising the steps:

[0088] (1) Weigh 3.99g NaOH (0.1mol) into a round bottom flask containing 100mL ethanol solution, add 12.81g 5,5-dimethylhydantoin (DMH, 0.1mol), reflux at 90°C for 10min; Adjust the temperature to 85°C, add 14.34g of 1-bromo-2-chloroethane (BCE, 0.1mol,) and continue to condense and reflux the reaction for 8h. White particles (sodium salt) can be seen in the solution. After removing ethanol by rotary evaporation at 80°C, Then wash with ethyl acetate / water (4 / 1, v / v), transfer the mixed solution to a separatory funnel, let it stand for 10 minutes to separate, keep the upper layer solution, and remove ethyl acetate by rotary evaporation at 60°C . The obtained product was poured into a beaker while it was hot (it can be observed that the solubility of the product decreases as the temperature decreases). The product 3-(2'-chloroethyl)-5,5-dimethylhydantoin (CEDMH) was a whi...

Embodiment 2

[0094] Embodiment 2 XG and CEDMH molar ratio optimization

[0095] Adjust the molar ratio of XG and CEDMH in Example 1 to 1:1, 1:2, 1:3, 1:4, 1:6, and keep the others consistent with Example 1 to obtain XG / CEDMH-Cl.

[0096] The obtained XG / CEDMH-Cl was subjected to a performance test, and the test results are shown in Table 1:

[0097] It can be seen from Table 1 that when the molar ratio of XG and CEDMH is 1:1, the chlorine content of the product XG / CEDMH-Cl is low, about 0.06%. Increasing the amount of CEDMH can gradually increase its grafting rate to XG, which is reflected in the gradual increase of the chlorine content of XG / CEDMH-Cl, but when the molar ratio of XG to CEDMH exceeds 1:5, the chlorine content does not increase much. Therefore, a scheme of 1:5 molar ratio of XG to CEDMH was chosen to prepare XG / CEDMH-Cl.

[0098] The test result of table 1 embodiment 1 and 2

[0099]

Embodiment 3

[0101] A method for preparing haloamine modified xanthan gum / chitosan composite antibacterial dressing, the process is as follows image 3 , including the following steps:

[0102] Add 0.15 g of XG / CEDMH-Cl obtained in Example 1 into 30 mL of water to dissolve; then add 2 mL of glycerin and continue stirring; 3 COOH aqueous solution is used as the solvent to prepare chitosan (CS) solution with a concentration of 0.5% (0.03g chitosan prepares 6mL chitosan solution); use a syringe with a blue needle (type 22G) to inject 6mL CS solution into the XG with high-speed stirring / CEDMH-Cl solution, mix evenly, then pour the mixture into a petri dish, and dry at 37°C to obtain a haloamine-modified xanthan gum / chitosan composite antibacterial dressing (XG / CEDMH-Cl&CS ​​dressing film).

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Abstract

The invention discloses a halamine modified xanthan gum / chitosan composite antibacterial dressing and a preparation method thereof, and belongs to the technical field of medical treatment. The preparation method comprises the following steps: combining two biopolymer materials of xanthan gum and chitosan, firstly, carrying out a grafting reaction on a halamine compound precursor 3-(2 '-chloroethyl)-5, 5-dimethyl hydantoin (CEDMH) and xanthan gum (XG), and matching with organic chlorination to prepare an antibacterial agent XG / CEDMH-Cl, the molar ratio of xanthan gum to 3-(2'-chloroethyl)-5, 5-dimethyl hydantoin (CEDMH) being 1: (1-6); then compounding chitosan (CS) and XG / CEDMH-Cl to prepare a polyelectrolyte complex, adding glycerol at the same time, and drying the product to obtain XG / CEDMH-Cl&CS composite antibacterial dressing, wherein the mass ratio of chitosan to XG / CEDMH-Cl is (1-5): 1. The composite antibacterial dressing obtained by the preparation method has a good antibacterial effect and good biocompatibility.

Description

technical field [0001] The invention relates to a haloamine-modified xanthan gum / chitosan composite antibacterial dressing and a preparation method thereof, belonging to the field of medical technology. Background technique [0002] Wounds are a heavy burden for patients, and the pain it brings is the oldest health problem that plagues human beings. Due to the extravasation and accumulation of interstitial fluid, wounds are easily infected by bacteria, which greatly hinders the healing process of the skin and prolongs recovery time required. Minor acute wounds such as small cuts and abrasions that occur in everyday life are often easily overlooked. In fact, due to the widespread existence of microorganisms such as bacteria and fungi, they can grow rapidly and form colonies on the wound, and further penetrate into deeper skin tissue layers to cause internal infections. Therefore, these acute wounds are at risk of becoming chronic wounds. According to reports, in the United...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/46C08B37/02
CPCA61L15/225A61L15/28A61L15/46A61L2300/232A61L2300/404C08B37/0033C08L5/00C08L5/08
Inventor 刘颖任学宏郑玉霞张建勋涂晓越
Owner JIANGNAN UNIV
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