Adsorbing material for blood purification and preparation method thereof

A technology of adsorption material and adsorption resin, which is applied in the fields of biochemical separation and biomedical materials, and achieves the effects of low hemolysis rate, improved safety, and strong adsorption and removal ability

Active Publication Date: 2021-08-20
佛山市博新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant application of ginsenosides for the preparation of adsorption materials

Method used

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  • Adsorbing material for blood purification and preparation method thereof
  • Adsorbing material for blood purification and preparation method thereof
  • Adsorbing material for blood purification and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] S1. Synthetic adsorption resin microspheres:

[0042] Heat and dissolve 5g of gelatin in purified water, add 40g of styrene, 55g of divinylbenzene, 3g of benzoyl peroxide, 160g of toluene, 20g of isooctane, an appropriate amount of liquid paraffin and 6g of vinylpyrrolidone, stir well, and then Add 0.6 g of calcium phosphate, gradually raise the temperature to 75°C, and set the shape for 3 hours to obtain pre-microspheres, which are then subjected to suspension polymerization at 80°C for 24 hours to prepare adsorption resin microspheres M1;

[0043]S2. Modification of adsorption resin microspheres:

[0044] The modification method of the adsorption resin microspheres M1 in this embodiment is double bond epoxidation modification, and the modification steps are: take 10 g of the adsorption resin microspheres M1, add 40 mL of dichloroethane to soak for 24 hours, drop by drop Add 20 mL of 10% m-chloroperoxybenzoic acid dichloride ethane solution, stir in an ice-water bath ...

Embodiment 2

[0048] S1. Synthetic adsorption resin microspheres:

[0049] Heat and dissolve 4g of gelatin in purified water, add 50g of styrene, 45g of divinylbenzene, 2g of benzoyl peroxide, 175g of toluene, 25g of isooctane and 7g of hydroxyethyl methacrylate, stir well, and then add Calcium phosphate 0.5g, gradually raise the temperature to 75°C, and set the shape for 2 hours to obtain the pre-microspheres, and continue to carry out the suspension polymerization reaction at 80°C for 24 hours to prepare the adsorption resin microspheres M2;

[0050] S2. Modification of adsorption resin microspheres:

[0051] The modification method of the adsorption resin microspheres M2 in this embodiment is double bond epoxidation modification, and the modification steps are: take 10 g of the adsorption resin microspheres M2, add 40 mL of dichloroethane to soak for 24 hours, drop by drop Add 5mL of 30% hydrogen peroxide and 5g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), stir ...

Embodiment 3

[0062] S1. Synthetic adsorption resin microspheres:

[0063] Take 3g of polyvinyl alcohol and dissolve it in purified water, add 45g of styrene, 50g of divinylbenzene, 4g of benzoyl peroxide, 124g of toluene, 53g of isooctane and 4g of methacryloyloxyethylphosphorylcholine , after stirring evenly, gradually raise the temperature to 75°C, set the shape for 3 hours to obtain pre-microspheres, and continue to carry out the suspension polymerization reaction of the pre-microspheres at 80°C for 24 hours to prepare the adsorption resin microspheres M3;

[0064] S2. Modification of adsorption resin microspheres:

[0065] The modification method of the adsorption resin microspheres M3 in this comparative example is the chloromethylation modification of the benzene ring. The modification steps are: take 10 g of the adsorption resin microspheres M3 and add them to 40 mL of chloromethyl ether solution to swell for 2 hours, then add 6 g Zinc chloride was heated to 42°C, and the chloromet...

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Abstract

The invention discloses an adsorption material, which comprises adsorption resin microspheres, wherein ginsenoside is immobilized on the adsorption resin microspheres, the adsorption resin microspheres are of a porous structure, and the average pore diameter of the adsorption resin microspheres is 3-20 nm. The preparation method of the adsorption material comprises the following steps: synthesizing adsorption resin microspheres; modifying the adsorption resin microspheres, wherein the modification mode is double-bond epoxidation modification or benzene ring chloromethylation modification; and immobilizing ginsenoside. According to the invention, by immobilizing ginsenoside on the adsorption resin microspheres, the aperture structure of the adsorption resin microspheres is matched with the molecular size of a target adsorption chemotherapeutic drug so as to achieve the relative specific adsorption capacity of the adsorption resin microspheres to the chemotherapeutic drug, and the ginsenoside has an antibacterial effect, so that the risk of blood-borne infection can be reduced, and the application safety of the ginsenoside in the field of blood purification can be improved; and the adsorption material disclosed by the invention, the adsorption removal rate of chemotherapeutic drugs reaches 90% or above, and the hemolysis rate is less than 5%.

Description

technical field [0001] The invention relates to the technical field of biochemical separation and biomedical materials, in particular to an adsorption material and a preparation method thereof. Background technique [0002] In recent years, the proportion of drug poisoning has increased significantly, there are many mass poisoning incidents of banned rodenticides, and frequent occupational acute poisoning incidents of organic solvents, etc., resulting in an increase in sudden incidents and mass poisoning incidents. Therefore, in the use of traditional medical treatment At the same time, how to remove the poison from the patient's body more quickly and effectively has become the key to the success of the rescue. [0003] Cancer is a disease with a high fatality rate at present. Traditional treatment methods mainly target cancer cells, which are highly toxic and have obvious side effects. After chemotherapy, there are cases of high residual chemotherapy drugs. Cancer patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCB01J20/265B01J20/28016B01J20/28054B01J20/28083A61M1/3679A61M2202/0413A61M2202/0021
Inventor 姜建明李设桥
Owner 佛山市博新生物科技有限公司
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