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Composite adsorbent and preparation method thereof

A composite, adsorbent technology, applied in chemical instruments and methods, other chemical processes, alkali metal compounds, etc., can solve problems such as limited clinical treatment effect, achieve good blood compatibility, good adsorption selectivity, and broad application Foreground effect

Pending Publication Date: 2020-08-25
威海威高生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, most of the adsorbents developed for endotoxemia are only aimed at the removal of endotoxin, ignoring the impact of explosive inflammatory factors, so the clinical treatment effect is limited

Method used

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  • Composite adsorbent and preparation method thereof
  • Composite adsorbent and preparation method thereof
  • Composite adsorbent and preparation method thereof

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preparation example Construction

[0027] The present invention also provides a kind of preparation method of composite adsorbent, comprising the following steps:

[0028] a) Epoxy-activating the hydroxyl groups of the polysaccharide carrier to obtain an epoxy-activated polysaccharide carrier;

[0029] b) mixing and reacting the epoxy-activated polysaccharide carrier, hexadecylamine and polymyxin B sulfate in a solvent to obtain a composite adsorbent.

[0030]In the preparation method provided by the present invention, firstly, the hydroxyl group of the polysaccharide carrier is epoxy-activated to obtain the epoxy-activated polysaccharide carrier. Wherein, the polysaccharide carrier preferably includes dextran microspheres and / or cellulose microspheres; the average particle diameter of the polysaccharide carrier is preferably 380-1200 μm, more preferably 450-800 μm, specifically 450 μm 、460μm、470μm、480μm、490μm、500μm、510μm、520μm、530μm、540μm、550μm、560μm、570μm、580μm、590μm、600μm、610μm、620μm、630μm、640μm、650μm、660μm...

Embodiment 1

[0037] 1) Activation of cellulose microspheres:

[0038] Prepare cellulose microspheres, the particle size distribution of the cellulose microspheres is 380-1000 μm, the average particle size is 690 μm, the solid content is 30 g / dL, and the molecular weight cut-off is about 40 kDa. Weigh 30 mL of the above-mentioned cellulose microspheres, wash the cellulose microspheres with 20 wt%, 50 wt%, 70 wt% dimethyl sulfoxide aqueous solution and 100% dimethyl sulfoxide successively, and replace with pure di Methyl sulfoxide environment, drain dimethyl sulfoxide, transfer to the reaction kettle; add dimethyl sulfoxide according to the volume ratio of cellulose microspheres after draining 1:1, add the cellulose microspheres after draining Epichlorohydrin with 40% of the volume of the spheres, and add sodium hydroxide at a ratio of 2 g to 100 mL of cellulose microspheres after draining, and react at 50 ° C for 4 hours. After the activation of cellulose microspheres is completed, dimethyl...

Embodiment 2

[0042] 1) Activation of cellulose microspheres:

[0043] Prepare cellulose microspheres, the particle size distribution of the cellulose microspheres is 380-1000 μm, the average particle size is 690 μm, the solid content is 30 g / dL, and the molecular weight cut-off is about 40 kDa. Weigh 30 mL of the above-mentioned cellulose microspheres, wash the cellulose microspheres with 20 wt%, 50 wt%, 70 wt% dimethyl sulfoxide aqueous solution and 100% dimethyl sulfoxide successively, and replace with pure di In the methyl sulfoxide environment, drain the dimethyl sulfoxide and transfer it to the reaction kettle; add dimethyl sulfoxide according to the volume ratio of the cellulose microspheres after draining 1:1, and add the cellulose microspheres after draining Epichlorohydrin with 40% volume of the ball, and add sodium hydroxide at a ratio of 2 g to 100 mL of cellulose microspheres after draining, and react at 50 ° C for 4 hours. After the activation of cellulose microspheres is comp...

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Abstract

The invention belongs to the field of adsorption materials, and particularly relates to a composite adsorbent and a preparation method thereof. The composite adsorbent provided by the invention comprises a polysaccharide carrier, and hexadecyl and polymyxin B which are grafted on the polysaccharide carrier. According to the preparation method, a polysaccharide material is used as an adsorbent carrier and has very excellent hydrophilicity and blood compatibility, so that the material does not need to be coated subsequently, and a series of problems caused by unstable coating are avoided; meanwhile, the hexadetyl and the polymyxin B are grafted and immobilized on the carrier, so the adsorbent has good adsorption selectivity on endotoxin and inflammatory factors in blood; in the actual use process, the adsorbent provided by the invention adsorbs little impure protein in blood, can effectively reduce the invasion of the impure protein to the adsorption capacity, improves the adsorption removal effect of endotoxin and inflammatory factors, and has a wide application prospect in the field of endotoxemia treatment.

Description

technical field [0001] The invention belongs to the field of adsorption materials, in particular to a composite adsorbent and a preparation method thereof. Background technique [0002] Endotoxemia is a pathophysiological manifestation caused by bacteria in the blood or in the lesion releasing a large amount of endotoxin into the blood, or transfusing a large amount of endotoxin-contaminated fluid, usually leading to sepsis, multiple organ failure, Disseminated intravascular coagulation and a series of complications with high mortality rate. Although it is caused by bacterial infection, the release of inflammatory factors plays a vital role in the development of the disease as the body responds to infectious factors. Hemoperfusion using endotoxin adsorbents can be used to remove endotoxins in related patients, so as to relieve related symptoms and improve the survival rate of patients. [0003] At present, the endotoxin adsorbents used in hemoperfusion mostly use activated...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/28B01J20/30
CPCB01J20/24B01J20/22B01J20/28021
Inventor 于之渊薛云燕李凯吴春凤郭杨柳
Owner 威海威高生命科技有限公司
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