The invention discloses a simple and convenient synthesis method of 9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a] quinolizidine-2-ketone. According to the invention, easy raw material source is obtained; the preparation cost of the medicine is largely saved by using cheap and easily obtained 5-methyl-2-hexanone as raw material; and the structures of an immediate and a target compound are certified through verifications of nuclear magnetic resonance spectrum, mass spectrum, infrared spectrum and the like; the simple and convenient synthesis method of the 9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a] quinolizidine-2-ketone, disclosed by the invention, has the advantages of simplified synthesis process, two-step reaction, mild condition for the synthesis method, short reaction time, simplicity and convenience in operation and easiness in separation and purification; the shortcomings in the prior art are also avoided; the green synthesis process has the advantages of mild condition, simplicity and convenience in operation and environment friendliness; and a green synthesis way is provided for the synthesis of the 9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a] quinolizidine-2-ketone.