Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Alcohol free formulation of argatroban

A technology of argatroban and preparation, applied in the field of argatroban and related compounds, can solve the problems of material waste and the like

Inactive Publication Date: 2009-08-26
SCIDOSE
View PDF2 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, each supplied vial provides 250 ml of dosable diluent, resulting in significant material waste during almost most extended procedures (250 ml is sufficient for a 50 kg patient in 40 hours and for a 140 kg patient within 14 hours is sufficient)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Alcohol free formulation of argatroban
  • Alcohol free formulation of argatroban
  • Alcohol free formulation of argatroban

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] (2R, 4R)-1-[N 2 -(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid (argatroban) was Dissolve (to a concentration of 5 mg / ml) in an aqueous system containing 50 mg / ml arginine and adjust the pH of the final solution to 9.0 using acetic acid. Dissolution of argatroban was performed at 25°C.

Embodiment 2

[0069] Argatroban was dissolved (to a concentration of 5 mg / ml) in an aqueous system containing 50 mg / ml arginine and the pH was adjusted to 9.0 using acetic acid. Dissolution of argatroban was performed at 50°C.

Embodiment 3

[0071] Argatroban was dissolved (up to a concentration of 5 mg / ml) in an aqueous system containing 50 mg / ml arginine and the pH was adjusted to 9.0 using tartaric acid. Dissolution of argatroban was performed at 25°C.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an aqueous formulation of argatroban and of related compounds along with a reconstitutable formulation, each of which is substantially, if not totally alcohol free. The formulations are also substantially free, if not totally free, of mono-, di-, and oligo- saccharides. An especially preferred embodiment is a ready-to-use 1 mg / ml injectable dosage form having argatroban, lactobionic acid, and methionine.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application 60 / 850,725, filed October 11, 2006, and US Provisional Application 60 / 847,556, filed September 27, 2006. See also a co-owned US application filed contemporaneously with the same title and inventor as this application and claiming priority from the two identical provisional applications above. These applications, as well as each of these applications and each of the patents and patent applications mentioned in this specification, are incorporated herein by reference in their entirety. [0003] Statement Regarding Federally Sponsored Research or Development [0004] Not applicable technical field [0005] The present invention relates to argatroban and related compounds, and to the solubilization of argatroban and related compounds without the need for alcohol or other solvents and / or without the use of sugars to obtain injectable solutions having desired con...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/47
Inventor N·R·帕勒普
Owner SCIDOSE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com