Manufacturing method of coaxial electrostatic spinning magnetic anastomosed artificial blood vessel

A technology of coaxial electrospinning and artificial blood vessel, which is applied in the field of artificial blood vessel construction, can solve the problem of undiscovered artificial blood vessel manufacturing method, etc., and achieve the effect of convenient and fast anastomosis process, great clinical application value, and economic burden reduction.

Pending Publication Date: 2020-09-01
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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Problems solved by technology

However, there is still no effective method for making artificial blood vessels using magnetic anastomosis technology.

Method used

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  • Manufacturing method of coaxial electrostatic spinning magnetic anastomosed artificial blood vessel
  • Manufacturing method of coaxial electrostatic spinning magnetic anastomosed artificial blood vessel
  • Manufacturing method of coaxial electrostatic spinning magnetic anastomosed artificial blood vessel

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Embodiment Construction

[0049] see figure 1 , 2 , 3, the method of the specific embodiment of the present invention is as follows:

[0050] 1) Preparation of coaxial electrospinning solution:

[0051] Two solutions were prepared: heparin sodium solution and poly-L-lactide-caprolactone (PLCL, molecular weight: 150,000 Da, PLA:PCL=50:50) solution, wherein the heparin sodium solution was coaxial electrospun Core layer solution, PLCL solution is the shell layer solution of coaxial electrospinning.

[0052] 1.1) Preparation of heparin sodium solution: 200 mg of heparin sodium powder was dissolved in 1 ml of normal saline.

[0053] 1.1) Preparation of PLCL solution: 2 g of PLCL was dissolved in 10 ml of hexafluoroisopropanol (HFIP) and stirred until completely dissolved.

[0054] 2) 3D printing of electrospinning receivers

[0055] 2.1) Patients need to undergo CT angiography (CT angiography, CTA) examination before operation;

[0056] 2.2) Measure the length L and diameter D of the blood vessel to b...

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Abstract

The invention relates to a manufacturing method of a coaxial electrostatic spinning magnetic anastomosed artificial blood vessel. The method comprises the following steps: 1) preparing a coaxial electrostatic spinning solution; and preparing two solutions: namely a heparin sodium solution and a poly L-lactide-caprolactone solution, wherein the heparin sodium solution is a core layer solution for coaxial electrostatic spinning, and the PLCL solution is a shell layer solution for coaxial electrostatic spinning; 2) carrying out 3D printing of an electrostatic spinning receiver: 2.1) carrying outCT angiography examination on a patient before an operation; 2.2) measuring the blood vessel length L and the blood vessel diameter D, which need to be replaced; 2.3) drawing a 3D model of an electrostatic spinning receiver by using SolidWorks software; and 2.4) manufacturing an electrostatic spinning receiver by using a 3D printer; and 3) manufacturing a coaxial electrostatic spinning magnetic anastomosed artificial blood vessel. The prepared magnetic anastomosed artificial blood vessel has a good microstructure, hydrophilicity and stable heparin slow release performance, and the blood compatibility, mechanical properties and animal in-vivo implantation experiments show that the magnetic anastomosed artificial blood vessel has the advantages that the anastomosis process is convenient andrapid, an anastomosed stoma is not narrow, and anticoagulant application is avoided.

Description

technical field [0001] The invention relates to the field of constructing artificial blood vessels, in particular to a manufacturing method of coaxial electrospinning magnetic anastomosis artificial blood vessels. Background technique [0002] Electrospinning technology has shown great potential for clinical application in the field of artificial blood vessel construction. However, similar to similar products, electrospun artificial blood vessels also have defects such as long anastomosis time and easy stenosis of anastomosis. Magnetic anastomosis is a sutureless anastomosis technique that has developed rapidly in recent years. It has the advantages of less tissue damage, no foreign matter remaining in the anastomotic site, and anastomotic stoma that is not easy to narrow. However, no effective method for making artificial blood vessels using the magnetic anastomosis technique has been found yet. Contents of the invention [0003] In order to solve the above-mentioned te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06A61L27/18A61L27/20A61L27/50B33Y10/00D01D5/00
CPCA61F2/06B33Y10/00A61L27/507A61L27/50A61L27/18A61L27/20D01D5/0015D01D5/0076A61F2240/002C08L67/04C08L5/10
Inventor 吕毅向俊西刘鹏杨丽斐史爱华钱叶蓉董鼎辉
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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