A five-axis multi-functional thread grinding machining center belongs to the numerically controlled machine tool field. The five-axis multi-functional thread grinding machining center consists of a machine tool body, a Z-direction slide plate, a workpiece electric spindle, a X-direction base plate, a post, a Y-direction slide plate, an A-axis turntable and a grinding electric spindle. A Z-direction servomotor drives a Z-direction lead screw to drive the Z- direction slide plate to perform Z-direction movement, the post is arranged on a X- direction guide rail slider, a X-direction servomotor drives an X-direction lead screw to drive the post to perform X-direction movement, a Y-direction guide rail is fixedly arranged on the post, the Y-direction slide plate is positioned on a Y-direction guide rail slider, a Y-direction servomotor drives a Y-direction lead screw to drive the Y-direction slide plate to perform Y-direction movement, the Z-direction slide plate is provided with the workpiece electric spindle, the A-axis turntable is arranged on the Y-direction slide plate and is connected with an A-axis servomotor, and the grinding electric spindle is fixed on the A-axis turntable by bolt fastening. The five-axis structure is adopted in the grinding machining center, thus simplifying machine tool structure, realizing grinding of super-long nuts, enlarging applicability of the machine tool and lowering manufacturing cost.