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73results about How to "Minimize adhesion" patented technology

Multi-lumen vascular catheter and method for manufacturing the same

A multilumen vascular catheter (1) for treatment of patients by insertion of the vascular catheter in a venous blood vessel (14) by means of a guide-wire (28), the vascular catheter having a proximal connection point (10), a distal end-portion (12) which is terminated within a guide-wire opening (26), and a flexible catheter tube (16) arranged between the proximal connection portion (10) and the distal end-portion (12). The catheter tube (16) has a first lumen (18) for extraction of fluid such as untreated blood from the vessel (1) and a second lumen (20) for introducing fluid such as treated blood to the blood vessel (14). One or more suction openings (22) communicate with the first lumen (18) and are located upstream of one or more outlet openings (24), which in turn communicate with the second lumen (20), the suction openings (22) and the outlet openings (24) being located at the distal end-portion (12). The distal end-portion (12) is permanently bulbous and has a first, widening section (A) starting from the catheter tube (16) with a gradually increasing external cross-section in the direction toward the guide-wire opening (26). The first section (A) transits downstream via a shoulder (30) with a maximum external diameter into a second, narrowing section (B) having a gradually decreasing external cross-section in the direction toward the guide-wire opening (26). One or more of the suction openings (22) are located in the first, widening section (A) of the distal end-portion (12) while one or more of the outlet openings (24) are located in the second, narrowing section (B).
Owner:NORDIC MED COM

Biological component comprising artificial membrane

A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e.g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present. To facilitate binding, the substrate may optionally be treated with a polyelectrolyte or alternating layers of oppositely-charged polyelectrolytes to facilitate charged binding of the membrane-mimetic film or alkylated layer beneath the membrane-mimetic film to the substrate. The membrane-mimetic film is preferably made by in situ polymerization of phospholipid vesicles.
Owner:EMORY UNIVERSITY
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