A high-boron cast alloy guide and its heat treatment method pertain to the technical field of steel rolling. The chemical composition of the guide provided by the present invention (mass fraction, %): C 0.25-0.45, Cr 12.0-15.0, B 1.0-2.5, Mo 0.5-0.8, Mn 1.8-2.5, Al 0.10-0.30, Re 0.08-0.20, Mg 0.04-0.08, V 0.05-0.10, N 0.01-0.03, Ti 0.10-0.20, Nb 0.10-0.20, 0.25<=Ti+Nb<=0.35, Si<1.0, S<0.05, P<0.05, and Fe as the rest. Through smelting, casting, oil quenching, tempering and other steps, the present invention prepares a high-boron cast alloy guide with high hardness and strength, desirable tenacity and wear resistance, and low cost.