Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium

Abstract

The present invention concerns a novel stent and a method for communicating oxygenated blood directly from the left ventricle to the coronary sinus to provide retrograde perfusion to the myocardium. The stent is placed substantially within the coronary sinus with its trailing end protruding into the right atrium and the leading end protruding into the left ventricle. The stent has a smaller passageway at or near the trailing (right ventricular) end and at or near the leading (left ventricle) end, and has a covering at the trailing end. The smaller passageway and the cover at the trailing end to promote retrograde flow into the venous system of the hear and specifically the myocardium of the left ventricle and to reduce a significant left-to-right shunt.

Description

[0001] This application is a continuation-in-part of copending application Ser. No. 09 / 796,528, filed Mar. 2, 2001.[0002] 1. Field of Invention[0003] The present invention relates to a stent for supplying oxygenated blood retrogradely to the myocardium via the coronary sinus. The stent directs blood from the left ventricle to the coronary sinus through a hole punctured through the wall of the coronary sinus and the wall of the left ventricle and restricting the outflow of the coronary sinus directs that blood retrogradely.[0004] 2. Description of Related Technology[0005] Retrograde perfusion using the coronary sinus has long been known for treating end-stage heart disease. Previous methods among others attempted to connect the aorta to the coronary sinus using a jugular vein or an internal mammary artery graft. These methods were invasive in nature and required open heart surgery.[0006] U.S. Pat. No. 5,824,071, issued to Nelson et al. in 1998, discloses an apparatus and method for p...

AI Technical Summary

Benefits of technology

[0011] The smaller passageways (or constrictions) at or near the leading (LV) end and the trailing (RA) end of the stent operate to control the amount of blood flowing into and out of the coronary sinus. The size of the passageway of the constriction at the leading (LV) end controls the amount of inflow into the coronary sinus.

[0012] The cover surrounding the stent at the trailing (RA) end directs blood flow through the passageway at the trailing (RA) end, and the size of the passageway of the constriction at or near the trailing (RA) end controls the amount of outflow into the right atrium. They also control the retrograde flow of oxygenated blood to the myocardium. The stent preferably forms a friction fit with the lumen of the coronary sinus.

[0015] In the present invention, the smaller passageway and the cover of the trailing (RA) end restrict blood flow into the right atrium. With the increased pressure inside the coronary sinus, blood flows out through the open interstices of the stent retrogradely to perfuse the myocardium.

[0016] Some amount of blood flow into the right atrium through the coronary ostium, however, is necessary to control the pressure in the coronary sinus. The cross sectional area (or diameter) of the passageway at the trailing (RA) end (or constriction) should be large enough to prevent the coronary sinus pressure from rising above a suitable pressure, preferably about 50 mm Hg, while reducing a significant amount of left-to-right shunt. A suitable pressure limit avoids damage to the venous system draining into the coronary sinus while effectively providing retrograde perfusion. An optional covering at the leading (LV) end of the stent will help direct blood through the constriction at the leading (LV) end.

[0017] Thus, the present invention overcomes the difficulty in the prior art with an elegant and simple stent that retrogradely supplies oxygenated blood to the myocardium while decreasing the shunting of oxygenated blood from the left ventricle to the right atrium.

Problems solved by technology

These methods were invasive in nature and required open heart surgery.

Nelson, however, does not teach how such a valve may be constructed, and it is unlikely that such a device may be introduced percutaneously.

The stent employed by Patel et al., however, results in a significant shunt of oxygenating blood from the left ventricle to the right atrium (hereinafter "left-to-right shunt").

Further, although Patel recommends using a T or a Y shaped device, technical problems associated with accurately delivering such a device in place render the invention difficult.

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