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Pharmaceutical composition and application thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve problems such as quality of life and work problems, and achieve the effects of regulating gastrointestinal function, improving sensitivity, and protecting endothelial function

Inactive Publication Date: 2011-11-16
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cause some troubles to the quality of life and work

Method used

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  • Pharmaceutical composition and application thereof
  • Pharmaceutical composition and application thereof
  • Pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0047] Add 10 times the amount of distilled water to 1000g of Pueraria decoction pieces, reflux for 1.5 hours, and filter; add 8 times the amount of distilled water to the dregs, extract by reflux, filter, combine the two filtrates, concentrate under reduced pressure to 1 / 5 of the original volume, On the AB-8 macroporous resin, after elution with 4 times the column volume, use 60% ethanol to elute until the effluent is light-colored; collect the alcohol eluate, recover the solvent under reduced pressure, and freeze-dry to obtain the total volume of kudzu root. Isoflavones 87.6g, Pueraria isoflavones content is 63.2%.

[0048] Add 10 times the amount of water, extract by reflux for 1.5 hours, and filter; add 8 times the amount of water to the dregs, extract by reflux, combine the two filtrates, and concentrate under pressure to medicinal materials: water (1:10), Apply AB-8 macroporous resin, elute with 5 times the column volume of water, then use 70% ethanol to elute 6 times th...

Embodiment approach 2

[0052] Weigh 1000g of kudzu root, scutellaria baicalensis and Coptis chinensis pieces in proportion, add 10 times the amount of water, reflux extraction for 1.5 hours, filter; add 8 times the amount of water to the dregs, reflux extraction, combine the two filtrates, pressurize and concentrate To medical material: water (1: 10), on AB-8 macroporous resin, after elution with water of 5 times of column volume, use 50% ethanol to elute 5 times of column volume instead, collect ethanol eluent, reduce The solvent was recovered under pressure, and dried under reduced pressure at 60°C to obtain 81.3 g of the active part composition. Appropriate amount of starch is added, and the capsules are filled.

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Abstract

The invention discloses a pharmaceutical composition, which is prepared from the effective parts of kudzu vine root, baical skullcap root and coptis root. In the pharmaceutical composition, in terms of weight ratio, the isoflavone of the kudzu vice root accounts for 10 to 70%, the total flavonoids of the baical skullcap root accounts for 5 to 60%, and the total alkaloids of the coptis root accounts for 5 to 70%, preferably, the kudzu vine root accounts for 40%, the baical skullcap root accounts for 20% and the coptis root accounts for 40%. The composition is mainly used for the treatment of diabetes and complications thereof, and the treatment of irritable bowel syndromes.

Description

technical field [0001] The present invention relates to a preparation method of a traditional Chinese medicine effective part composition composed of total isoflavones of kudzu root, total flavonoids of scutellaria baicalensis and total alkaloids of coptis, and its application in treating diabetes and diabetic complications, and treating irritable bowel syndrome , belongs to the field of traditional Chinese medicine modernization technology. Background technique [0002] Diabetes is caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors that act on the body to cause hypofunction of pancreatic islets and insulin resistance (Insulin Resistance, IR), etc. A series of metabolic disorder syndromes caused by sugar, protein, fat, water and electrolytes, clinically characterized by hyperglycemia, typical cases may appear polyuria, polydipsia, polyphagia, weight loss and other manifestations,...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P1/00A61P3/10
Inventor 王跃生刘安章军
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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