11 results about "Antiseptic medication" patented technology

The invention provides a hinokitiol-dihydromyricetin composite nano condensation body and a preparation method and application thereof, and the composite nano condensation body comprises the following components in 100 mL of a suspension: 0.3 to 0.5 g of hinokitiol, 0.5 to 0.8 g of dihydromyricetin, 1.0 to 1.5 g of chitosan, 0.5 to 0.8 g of sodium alginate, 2.0 to 3.0 mL of polyethylene glycol, 0.3 to 0.5 mL of Tween, 1.0 to 1.5 mL of glycerol, and the balance of a citric acid-sodium citrate buffer solution. The invention provides a hinokitiol-dihydromyricetin composite nano-coacervate which can synchronously solve the problems of synergistic bacteriostasis, membrane rupture and antibiosis, anti-inflammatory repair, application defects of active ingredients and the like of common animal skin antibacterial drugs. The preparation method of the composite nano coacervate is simple, large-scale production is easy, complex equipment is not needed, it can be ensured that active ingredients of a finished product are evenly distributed, the composite nano coacervate can penetrate through the skin cuticle and can also penetrate through a bacterial biofilm, and the synergistic effect is fully achieved.

The utility model provides a fibrous membrane for guiding periodontal tissue regeneration, and relates to the technical field of medical instruments. Preparing a PLGA double-layer fiber membrane loaded with drug-loaded sodium hyaluronate particles through the cooperative work of electrostatic spinning and electrostatic spraying; the sodium hyaluronate particles can greatly improve the loading rate of hydrophilic anti-inflammatory antibacterial and bone regeneration promoting medicines; a PLGA compact layer in the PLGA double-layer fiber membrane is loaded with first sodium hyaluronate particles loaded with anti-inflammatory and antibacterial drugs, and when the first sodium hyaluronate particles make contact with gingival tissue, cell adhesion and permeation can be hindered, and the anti-inflammatory and antibacterial effects can be achieved; a PLGA loose layer in the PLGA double-layer fiber membrane carries second sodium hyaluronate particles loaded with a bone regeneration promoting medicine, and the second sodium hyaluronate particles can promote osteoblast adhesion and facilitate dentale regeneration when making contact with bone tissue.

The invention provides a drug-loaded intravascular stent and a preparation method thereof.The preparation method of the drug-loaded intravascular stent comprises the steps that drug-loaded microspheres are prepared; wherein the drug-loaded microspheres comprise chitosan nanoparticles loaded with an anti-inflammatory drug, an antibacterial drug layer coating the chitosan nanoparticles, and a PLGA (poly (lactic-co-glycolic acid)) shell layer coating the antibacterial drug layer; mixing the drug-loaded microspheres with PLGA (poly (lactic-co-glycolic acid)) microspheres to prepare a blended wire rod; and according to a digital model, carrying out 3D printing on the blended wire rod to form the drug-loaded intravascular stent.

This invention relates to the field of medical nursing equipment technology, specifically to a wound and stoma infection prevention and care device. It includes a bag body with an adhesive-coated base fixedly connected to it. The base has a slit in its center, and an annular cavity is fixedly connected to the side of the base closest to the skin. The wall of the annular cavity is made of silicone, and several through holes are formed in the inner wall of the annular cavity. Antibacterial medication is placed inside the annular cavity. An absorption component is provided on the base to assist in absorbing exudate and reduce the risk of infection. This invention, by setting a silicone annular cavity containing antibacterial medication on the skin side of the base, in conjunction with the absorbent resin strip component inside the base, achieves targeted release of antibacterial medication for sterilization and active absorption and transfer of exudate, thus reducing the risk of stoma infection through a dual effect.

The present application relates to the technical field of medical devices, in particular to a drug-loaded anastomosis nail processing technology, which comprises the following steps: slotting or drilling is performed on a metal wire by a laser cutting device, and the end of the metal wire is cut into a pointed end structure as a drug-loaded anastomosis nail base; the obtained drug-loaded anastomosis nail base is cleaned; the cleaned drug-loaded anastomosis nail base is fitted and installed on a spraying assembly, and a spraying solution containing an antibacterial drug and a polymer carrier is used to spray the drug-loaded anastomosis nail base under the condition that the spraying assembly drives the drug-loaded anastomosis nail base to rotate; the obtained sprayed drug-loaded anastomosis nail base is formed into a U-shaped nail on a nail forming tool, and the U-shaped nail is the drug-loaded anastomosis nail. The present application is provided with a drug-loading groove on the anastomosis nail, and the drug is sprayed into the drug-loading groove. When the anastomosis nail is used, the drug is continuously released through the nail foot of the drug-loaded anastomosis nail, and the wound healing is accelerated.

A method for constructing a graded limbal injury and repair model comprises: after administering topical anesthetic drops to the operated eye of a model animal, placing a limbal injury device containing a NaOH solution in the limbal area of ​​the model animal for 30 seconds, then removing the device and irrigating the operated eye with saline; postoperatively, administering an antibacterial drug to the operated eye of the model animal several times daily; and eight days after surgery, a graded limbal injury and repair model is obtained, wherein the limbal injury device applies alkali burns of varying sizes to the limbal area, thereby achieving a graded injury effect. The construction method provided by the present invention has been shown to be simple, laboratory-friendly, inexpensive, short, and reproducible, with quantifiable evaluation methods, making it an ideal method for constructing an animal model of limbal stem cell injury.

The present application belongs to the technical field of medical stents, and particularly relates to a drug-loaded polydopamine hydrogel filled polycaprolactone stent and a preparation method and application thereof. The polycaprolactone stent comprises a polycaprolactone stent body, and drug-loaded mesoporous ceramics and zeolite imidazolate framework material embedded in the polycaprolactone stent body; the drug-loaded mesoporous ceramics are embedded in the zeolite imidazolate framework material; the matrix material of the polycaprolactone stent body is polycaprolactone, the micropore structure between fibers and the surface of the fibers of the polycaprolactone has a micropore structure, and the size of the micropore structure between the fibers is greater than that of the surface of the fibers; the micropore structure is filled with drug-loaded polydopamine hydrogel. The polycaprolactone stent has good porosity, biocompatibility and antibacterial property, can induce stem cell osteogenic differentiation, can accelerate the release of antibacterial drugs in the case of infection, and the internally encapsulated drugs for promoting tissue regeneration and repair can be slowly released, and is suitable for the repair and regeneration of infected bone tissue defects.

The present invention relates to the technical field of bone scaffolds, and more specifically, to a bone scaffold composite material, a preparation method thereof, and a bone scaffold. The bone scaffold composite material prepared by the present invention has a layered structure, wherein the inner layer is a porous material loaded with a bone tissue repair-promoting drug, the middle layer is a polydopamine layer, and the outer layer is in situ grown Ag particles (antibacterial drugs). The material can be used to make a bone scaffold. In the prepared bone scaffold, the polydopamine layer plays a role in isolating the bone tissue repair-promoting drug and the antibacterial drug, thereby preventing the bone tissue repair-promoting drug and the antibacterial drug from reacting with each other and failing. Since the porous material loaded with the bone tissue repair-promoting drug is located in the inner layer, it can ensure that the bone tissue repair-promoting drug is released after the antibacterial drug is released. The bone scaffold provided by the present invention has an adjustable elastic modulus that can match the mechanical strength of human cancellous bone.

The present application discloses a three-dimensional stent, a preparation method therefor, and use thereof. Starting materials for preparing the three-dimensional stent provided by the present application include a carbon-inorganic oxide hybrid micro-nanofiber and carrageenan. The three-dimensional stent provided by the present application not only enables photo-thermal treatment, photo-thermal antibacterial effects, controlled drug release, and bone repair, but also has excellent biocompatibility and biological activity.

The invention provides an antibacterial drug-hydrogel composite dressing for nursing pressure sores and a preparation method thereof. The dressing is formed by compounding a surface layer, a middle antibacterial hydrogel layer and a bottom layer, the middle layer takes a carboxymethyl chitosan-polyacrylic acid copolymer as a matrix and is loaded with an antibacterial agent compounded by surface modified nano zinc oxide and polyhexamethylene biguanide hydrochloride and a healing promoting component compounded by recombinant human epidermal growth factors and aloe polysaccharide. The preparation process comprises the steps of nitrogen protection, standing curing and the like, and the process is controllable. Tests show that the dressing has an antibacterial rate of more than or equal to 99.2%, excellent air permeability and water absorption performance, a wound healing time shortening rate of more than or equal to 38%, and good fitness and biocompatibility which are obviously superior to those of a contrast, can be adapted to I-IV stage pressure sore nursing, is suitable for hospitals, families and other scenes, has good clinical application value, and can be produced on a large scale.

The synergistic antibacterial auricular point patch comprises a fixed layer, a first fiber membrane layer, a second fiber membrane layer and an acupoint stimulation part, a first cavity is formed between the first fiber membrane layer and the fixing layer, and a medicine for promoting qi to activate blood is loaded in the first cavity; the second fiber membrane layer is arranged on the periphery of the first fiber membrane layer in a concentric-square-shaped surrounding mode. A second cavity is formed between the second fiber membrane layer and the fixing layer, and an antibacterial medicine is loaded in the second cavity; a first mounting hole of the first fiber membrane layer is matched with an acupoint stimulation component, the upper end of the acupoint stimulation component penetrates through the first mounting hole and then is fixedly connected with the surface of the side, facing the ear skin, of the fixing layer, and the lower end of the acupoint stimulation component is higher than the lower end of the first fiber membrane layer. Therefore, the design reduces the risk of skin infection while enhancing the conditioning effect.