74 results about "Antiseptic medication" patented technology

Increased compliance in the use of topical sunscreens is obtained by combining a topical sunscreen agent in a formulation containing an antibacterial medication such as azelaic acid or an antibiotic.

The invention discloses an externally used nanometer silver antibiotic jel line products, which is characterized by the following: constituting with acceptable shaped agent, diluent, slow releasing agent, disperser on nanometer silver and medicinal; setting the grain size of the nanometer silver at 1-25nm; comprising push injecting agent, foam spray, aquagel cleaning solvent, spray and so on of nanometer silver antibiotic jel line products. This invention also relates to the preparing method of nanometer silver colloid and nanometer silver antibiotic jel line products. This product can be used to cure vaginitis, cervicitis, mixing infection type gynaecologic inflammation, prostatitis, prostate proliferation, prostatauxe, male urethritis, balanitis, posthitis and so on.

The present invention is one kind of antiseptic medicine composition containing antibiotic cefuroxime and beta-lactamase inhibitor in the weight ratio of 0.5-20. The said medicine composition as new generation of antiseptic medicine composition has the advantages of wide antiseptic spectrum and strong antiseptic effect.

A polyantiseptic antimicrobial pharmaceutical composition for oral use, for the hygiene and treatment of oral diseases of bacterial, mycotic or viral etiology, for over-the-counter sale, without contraindications. The composition does not contain phenolic or, chlorophenolic compounds, and consists of a mixture of hydrogen peroxide, eugenol, natural camphor, zinc sulphate, sodium fluoride, xylitol, cetylpyridinium chloride and excipients. The formulation is used to deodorise, disinfect, astringe and soothe inflammation of the oral area, avoids the neoformation of bacterial plaque, prevents tooth cavities, inhibits the formation of dental tartar, improves the resistance of teeth to cavities, and treats and prevents oral aphthous ulcers.

The invention provides application of dicycloplatin in preparation of an antiviral drug and / or antibacterial drug and application of the dicycloplatin in preparation of an antiviral adjuvant drug and / or antibacterial adjuvant drug. Viruses related in the invention are RNA viruses such as hepatitis B virus, hepatitis C virus, human immunodeficiency virus and influenza virus, and the antibacterial drug is resistant to mycobacterium tuberculosis and / or nontuberculosis mycobacteria, Research results prove that dicycloplatin has the effect of resisting multiple bacteria and viruses, especially has obvious inhibitory effect on drug-resistance bacteria, no obvious cytotoxicity and high medication safety.

The invention belongs to the medical material technical field, in particular to a calcium alginate-chitosan composite membrane medical dressing and a preparation method thereof; the preparation method comprises the following steps: mixing and stirring calcium alginate solution and chitosan acetic acid water solution containing glycerol fully, preparing films, and drying the films to obtain the dried calcium alginate-chitosan composite membrane medical dressing of the invention. The composite membrane medical dressing prepared by the method has excellent functions of hemostasis and antibiosis, wounds healing and has good mechanical strength and flexibility without toxic and side effect. The medical dressing can be used as biomedical material for clinical care, thus promoting the hemostasis of wounds, reducing the probability of wound infection and promoting the healing of wounds. Skin disinfectant or water soluble antibacterial drug can be used as admixture in the composite medical dressing prepared by the invention to improve the antibacterial and disinfect ability thereof, thus being applicable to the therapy of various surfaces of trauma or burn wounds.

The invention relates to a faked guaiane sesquiterpene lactone compound-Morgan blowball lactone A and the medicinable salt. The chemical name is 1-ketone-11(R)-hydroxyl-3, 5, 1(10)-trienin-faked lignum benedictum-8 alpha, 12-lactone. The compound could make medicine vehicle or medicine medicinal preparation with medicinable salt. The medicine contains other antibacterial druy. The preparation includes tablet, granule, capsule, oral liquid, drop pills, injection, skin penetrating agent, aerosol, etc. the compound could be used in medicine to prevent and cure anti gram positive fungus.

The invention discloses a sustained-release pro-drug with ibuprofen loaded by polylactic acid bonds, a method for preparing the sustained-release pro-drug by means of direct melt co-polymerization and application of the sustained-release pro-drug. The method includes steps of (1), mixing lactic acid and the ibuprofen with each other and carrying out pre-polymerization and dehydration treatment to obtain intermediates; (2), carrying out melt condensation polymerization on the obtained intermediates under the effects of catalysts, dissolving and precipitating reaction products and drying the reaction products under vacuum conditions to obtain the sustained-release pro-drug with the ibuprofen loaded by the polylactic acid bonds. The sustained-release pro-drug, the method and the application have the advantages that the sustained-release pro-drug with the ibuprofen loaded by the polylactic acid bonds is good in biological activity and is particularly excellent in antibacterial performance for Escherichia coli, staphylococcus aureus, candida albicans and the like; the method includes simple processes and is economical and practical; the sustained-release pro-drug with the ibuprofen loaded by the polylactic acid bonds can be used for preparing antibacterial drugs, anti-inflammatory drugs or anti-inflammatory dressing.

The invention discloses a ruthenium polypyridyl complex using quinolones compound as ligand, a preparation method and application thereof. The constitutional formula of the complex is as shown in a formula (I), wherein R1 denotes alkyl, substituted alkyl, naphthenic base, substituted naphthenic base, aryl or substituted aryl; R2 denotes ethyl or cyclopropyl; R3 denotes hydrogen or amido; R4 denotes hydrogen, fluorine, chlorine, cyan or amido; R5 denotes methyl, piperazinyl, cyclopentylamino, dimethylamino, methyl, halogen or hydrogen; R6 denotes hydrogen, fluorine or forms a hexatomic ring together with R1 through carbon atoms and oxygen atoms in a bonding way; R7 denotes hydrogen or methyl; R8 and R9 denote hydrogen or form a benzene ring through carbon atoms in a bonding way; and X and Y denote carbon atoms or nitrogen atoms. The invention uses quinolones compound as ligand and ruthenium polypyridyl group as active group to prepare medicine for curing tumors or antibacterial medicine, and has good antibacterial effect and bacteriostatic effect. Formula (1) is shown as the accompanying drawing.

The invention discloses a tinidazole nano-composite silver micro-emulsified antibiotics, 0.10 to 1.50 units of tinidazole and 0.008 to 0.020 units of nano-silver being regarded as medical components, and 96.92 to 99.67 units of micro-emulsified substrate and 0.30 to 3.00 units of auxiliary materials are evenly mixed together with a certain percentage, then the tinidazole complex nano-silver micro-emulsified antibiotics can be got which has a yellow outlook, the diameter of grains is 1nm to 100nm, the invention is stable, which can not only disturb the synthesis of DNA, but also be able to combine with oxygen metabolic enzyme (-SH) to interrupt the respiration metabolism process, so as to kill the aerobic and anaerobic pathogens and improve the recovery of wounds, and diseases such as vaginitis, endometritis can be quickly and effectively cured, and the preparation method of the invention is simple and safe.

The invention discloses an application of biotransformation bear gall powder for preparing an antibacterial medicine. The antimicrobial activity of the biotransformation bear gall powder is researched, and the in-vitro anti-purulency streptococcus and anti-pneumonia streptococcus experiment and the in vivo anti-pneumonia streptococcus experiment of the biotransformation bear gall powder are respectively carried out. Experiment results show the application of the biotransformation bear gall powder in preparing antibacterial medicines, and especially the application of the biotransformation bear gall powder in preparing an anti-purulency streptococcus orand anti-pneumonia streptococcus medicine.

The invention belongs to the field of medical dressings, and specifically relates to an antibacterial medical dressing capable of promoting the rapid healing of wounds and a preparation method thereof. The medical dressing can cooperatively use various active components such as vascular endothelial growth factors, silk fibroin, alginate and antibacterial drugs, so that long-acting bacteriostasis can be realized, and wound infection can be prevented; and the medical dressing has synergistic effects on promoting the rapid growing of the granulation tissue of the wounds, so that the purpose of the rapid healing of the wounds can be achieved, and no recurrence occurs after treatment.

The invention provides an externally applied medicine composition for treating common acne, which contains a novel retinoic acid medicine selectively developed for a receptor as a first pharmacological active ingredient A, an antibacterial agent as a second pharmacological active ingredient B, and either polyoxyl (40) stearate or polyoxyl (15) stearate as a solvent component C. Compared with an ordinary cream, the cream containing the solvent component C is easier to uniformly emulsify in the preparation process; furthermore, the physical characteristics of the cream in the storing process are more stable; in addition, the compatibility between a medicament and the skin is increased via the solvent component C in the using process, the contact between the medicine and focus parts is increased, and the medicinal cure effect is increased.

The invention discloses Myrtucommulone R and application thereof in preparing antibacterial drug. Structure of phloroglucinol tripolymer Myrtucommulone R is shown as a formula I, and Myrtucommulone R is a new natural product. The compound even at low concentration has remarkable antibacterial activity to staphylococcus aureus, methicillin-resistant staphylococcus aureus, vancomycin-intermediate-resistant staphylococcus aureus and vancomycin-resistant enterococcus faecium and has quite low toxicity to eukaryocytes, indicating that the compound has good medicinal prospect and can be applied to preparing an antibacterial drug preparation. The antibacterial drug preparation contains Myrtucommulone R and the balance of medicinal auxiliary materials or other compatible drugs. The antibacterial drug preparation includes various clinical drug dosage forms.

The invention relates to the field of cloth preparation, in particular to an antibacterial garment cloth preparation system and preparation process. The process comprises the following steps of 1, enabling cloth to pass through a device, immersing the formed cloth into antibacterial agent liquid, continuously immersing the cloth into the antibacterial agent liquid, and pulling out the cloth; 2, starting a motor to drive a cloth beating mechanism to beat the cloth, so that an antibacterial agent can be fully blended into the cloth; 3, driving stirring blades to stir the antibacterial agent liquid while two rotating shafts rotate, and pushing the antibacterial agent liquid to the beaten cloth at the same time; 4, starting a vibration motor to drive two vibration rollers to drive the cloth to vibrate, so that the cloth is switched between a tensioned state and a relaxed state back and forth, and the efficiency that the antibacterial agent is fully blended into the cloth is further improved; and 5, rotating an adjusting bolt, and driving a moving frame to move rightwards in a threaded manner, so that the force of abutting against a dewatering fixed roller by a clamping roller is increased, and the cloth is rapidly dewatered.

The invention relates to an antibacterial transparent dressing, a preparing method of the antibacterial transparent dressing and application of the antibacterial transparent dressing. The antibacterial transparent dressing comprises a polymer gel lining pad and a transparent protective film, wherein the polymer gel lining pad has moisture absorption performance and long-acting bacteriostasis performance; antibacterial drug is contained in the polymer gel lining pad; the polymer gel lining pad is prepared from materials of the following polymer monomers including hydroxyethyl methylacrylate, methyl methacrylate, cinnamic acid, alpha-cyanoacrylate, alpha-carboxymethyl crylic acid, methyl alpha-chloroacrylate and crylic acid-2-hydroxyl ethyl ester; the antibacterial drug is selected from chlorhexidine gluconate, chlorhexidine acetate, polyhexamethylene guanide salts and triclosan; the transparent protective film is a polyurethane thin film.

The nanometer antibacterial erythromycin medicine consists of erythromycin in 0.5-1.5 wt% and nanometer emulsion matrix in 98.5-99.5 wt%. It is yellowish transparent liquid, and has medicine granularity of 1-100 nm, low viscosity, high stability, fast absorption, targeted medicine release, high bioavailability, less toxic side effect and other features. The medicine may be attached well onto bacteria and permeated into bacteria to disturb their metabolism and to reach bacteriostasis and bactericidal effect. It is used mainly for treating serious infection caused by penicillin resisting staphylococcus aureus and hemolytic streptococcus as well as chicken's chronic respiratory tract disease, malignant rhinitis, etc. The medicine has simple preparation process, less toxicity and high safety.

The invention discloses a preparing method of (E)-N'-arylmethylene-4-(coumarin-3-yl)thiazole-2-hydrazide compound and its application. A formula (I) of the compound is shown as below. The preparing method includes: making salicylic aldehyde and ethyl acetoacetate into 3-acetylindole-2H-chromene-2-one, allowing bromization, cyclization and hydrazinolysis to obtain 4-(2-oxo-2H-chromene-3-yl)thiazole-2-hydrazine, and allowing the 4-(2-oxo-2H-chromene-3-yl)thiazole-2-hydrazine to react with substituted benzaldehydes to obtain the target compound. The compound can serve as a raw material for antiseptic medicine; the preparing method has the advantages that the raw materials are simple and easy to obtain and operating is convenient.

The present invention provides a safe antibacterial composition for topical administration which stably contains a penem antibiotic having a broad-spectrum and potent antibacterial activity while otherwise being chemically susceptible to hydrolysis, oxidation, photoisomerization or the like. The compositions of the present invention comprise an antibacterial composition for topical administration comprising a penem antibiotic or a pharmaceutically acceptable salt thereof in a non-aqueous base.

The invention discloses a preparation method of a biological glass mat. The preparation method comprises the following steps of processing borate biological glass fibers into chopped fibers which are 5-30 millimeters long, paving the chopped fibers in a mold, adding a modified chitosan liquid phase so that a ratio of the modified chitosan liquid phase to the borate biological glass fibers is 1.0-15ml / g, reacting for 0.5-4 hours and dipping the compound in a diluted acid of which the pH value ranges from 5.5 to 6.5, washing and then heating at 80 DEG C and drying to obtain the porous biological glass mat. The invention also discloses use of the biological glass mat prepared by the method in treating skin injuries. The biological glass mat prepared by the method is a wound skin regeneration / repair biological material which has a series of characteristics such as biocompatibility, bioactivity, biodegradability, biological antibacterial activity, antibacterial agent slow-release property and tissue regeneration property.

The invention relates to a vterinary drug granule for preventing and curing avian colibacillosis and a preparation method thereof, and the vterinary drug granule is characterized by comprising the following medicaments by weight portions: 1 to 3 portions of rhizoma coptidis, 1 to 6 portions of rhubarb and 1 to 4 portions of bikal skullcap root. The invention has the advantages of solving the problem of drug residues which exist in the existing antibacterials and being able to satisfy the people's growing needs for producing green pollution-free animal products. The drug is a pure veterinary drug, does not have drug residues, and does not have toxic side effect to organism.

A polyantiseptic antimicrobial pharmaceutical composition for oral use, for the hygiene and treatment of oral diseases of bacterial, mycotic or viral etiology, for over-the-counter sale, without contraindications. The composition does not contain phenolic or, chlorophenolic compounds, and consists of a mixture of hydrogen peroxide, eugenol, natural camphor, zinc sulphate, sodium fluoride, xylitol, cetylpyridinium chloride and excipients. The formulation is used to deodorise, disinfect, astringe and soothe inflammation of the oral area, avoids the neoformation of bacterial plaque, prevents tooth cavities, inhibits the formation of dental tartar, improves the resistance of teeth to cavities, and treats and prevents oral aphthous ulcers.

The invention discloses clotrimazole cream and a preparation method thereof. The clotrimazole cream comprises components in percentage by mass as follows: 1% of clotrimazole, 17%-34% of oleaginous bases, 4%-6% of an emulsifying agent, 5%-10% of a moisturizer, 1.1%-3% of a preservative, 0.03%-0.05% of a complexing agent and the balance of water. According to the clotrimazole cream, the antibacterial drug clotrimazole with the concentration of 1% is reasonably proportioned with components such as the preservative with antibacterial activity and the like, so that the antibacterial drug plays the important role, can improve the trichomonas killing effect, can be used for treating bacterial vaginitis, trichomonas vaginitis, senile vaginitis, male balanitis, penis itching and the like clinically, and enlarges the treatment range.

The invention provides a group of NZ2114 histidine mutants, and a preparation method thereof. Two histidine sites existing in an NZ2114 sequence are selectively mutated by using a protein directional transformation. The histidine mutants with the amino acid sequences represented by SEQ ID NO:1 to SEQ ID NO:5 are designed, and recombinant expression of the histidine mutants in Pichia pastoris is realized. Design of an NZ2114 histidine mutantderivative is realized for the first time, and a determination result shows that the mutants (especially the 16th histidine mutant) has substantial bacteriostatic activity on Staphylococcus aureus ATCC 25923, ATCC 43300 and ATCC 6538 and Streptococcus suis CVCC 3928 and CVCC 3309, and the MIC value is 0.0625-2 [mu]g / ml. The NZ2114 histidine mutants obtained through the method can be applied to the fields of antibacterial drugs, food additives, cosmetics and feed additives, and has wide application values and market prospect.

The invention provides an anti-bacterial and anti-inflammatory porous metal stent and a preparation method and application thereof. The preparation method includes the steps that a porous metal stentis subjected to surface treatment; the porous metal stent obtained after surface treatment is reacted with heparin, and a heparin layer is formed on the surface of the porous metal stent; the heparinlayer is modified with a polysaccharide complex of metal oxide nanoparticles and an antibacterial agent, and then the anti-bacterial and anti-inflammatory porous metal stent is obtained. By means of the method, the porous metal stent with the biological effect of long-acting antibacterial oxidative stress resistance can be obtained, and postoperative tissue repair is effectively improved.

The invention provides a streptococcus, which is a new species in streptococcus, is named as Streptococcus sp.64, is registered and preserved in Guangdong Microbial Culture Collection Center, and has a preservation number of GDMCC No: 61194. The Streptococcus sp. 64 disclosed by the invention can generate relatively strong bacteriostatic active substances after being subjected to fermentation culture, has a relatively obvious bacteriostatic effect on pseudomonas aeruginosa, burkholderia pseudomallei and the like, has a wide development space in prevention and treatment of diseases caused by the pseudomonas aeruginosa, the burkholderia pseudomallei and the like, and has the good development and application prospects in the aspect of antibacterial drugs.