19 results about "Antiseptic medication" patented technology

The invention discloses a hydroxytyrosol ectoine eutectic as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The molar ratio of hydroxytyrosol to Ectoine in the hydroxytyrosol Ectoine eutectic is 1: 1. The preparation method comprises the following steps: (1) weighing hydroxytyrosol and Ectoin according to a molar ratio, adding the hydroxytyrosol and Ectoin into a solvent, and carrying out heat preservation and stirring until the hydroxytyrosol and Ectoin are completely dissolved; (2) depressurizing the solution in the step (1) to remove the solvent to obtain a concentrated solution; and (3) carrying out low-temperature stirring crystallization on the concentrated solution, and drying to obtain the hydroxytyrosol Ectoine eutectic. The hydroxytyrosol Ectoin eutectic can be used for preparing anti-inflammatory drugs, vascular dilation drugs, antibacterial drugs or anti-cancer drugs, and can also be used for preparing moisturizing cosmetics, anti-aging cosmetics, anti-oxidation cosmetics, anti-wrinkle cosmetics and repair cosmetics. According to the hydroxytyrosol Ectoine eutectic prepared by the invention, the melting point of hydroxytyrosol can be increased from the molecular level, the stability of hydroxytyrosol is improved, and the application field of hydroxytyrosol is widened.

The present invention relates to a free-flowing topical powder formulation also termed as powder-to-cream formulation. The invention particularly relates to a formulation in the form of a powder but which, when applied, spreads on the skin just like a cream. The invention offers an ideal topical formulation having advantages of both a powder and a cream wherein ease of handling of powder is combined with the smoothness and spreadability of cream and presents a better choice for several active ingredients that are applied topically. The present invention provides a technology to deliver several actives from categories including but not limited to antiviral agents, Actives for Acne treatment, Alpha hydroxyacids, Anaesthetics (anesthestics), Antibacterials, Antifungals etc.

The invention provides a hinokitiol-dihydromyricetin composite nano condensation body and a preparation method and application thereof, and the composite nano condensation body comprises the following components in 100 mL of a suspension: 0.3 to 0.5 g of hinokitiol, 0.5 to 0.8 g of dihydromyricetin, 1.0 to 1.5 g of chitosan, 0.5 to 0.8 g of sodium alginate, 2.0 to 3.0 mL of polyethylene glycol, 0.3 to 0.5 mL of Tween, 1.0 to 1.5 mL of glycerol, and the balance of a citric acid-sodium citrate buffer solution. The invention provides a hinokitiol-dihydromyricetin composite nano-coacervate which can synchronously solve the problems of synergistic bacteriostasis, membrane rupture and antibiosis, anti-inflammatory repair, application defects of active ingredients and the like of common animal skin antibacterial drugs. The preparation method of the composite nano coacervate is simple, large-scale production is easy, complex equipment is not needed, it can be ensured that active ingredients of a finished product are evenly distributed, the composite nano coacervate can penetrate through the skin cuticle and can also penetrate through a bacterial biofilm, and the synergistic effect is fully achieved.

The utility model provides a fibrous membrane for guiding periodontal tissue regeneration, and relates to the technical field of medical instruments. Preparing a PLGA double-layer fiber membrane loaded with drug-loaded sodium hyaluronate particles through the cooperative work of electrostatic spinning and electrostatic spraying; the sodium hyaluronate particles can greatly improve the loading rate of hydrophilic anti-inflammatory antibacterial and bone regeneration promoting medicines; a PLGA compact layer in the PLGA double-layer fiber membrane is loaded with first sodium hyaluronate particles loaded with anti-inflammatory and antibacterial drugs, and when the first sodium hyaluronate particles make contact with gingival tissue, cell adhesion and permeation can be hindered, and the anti-inflammatory and antibacterial effects can be achieved; a PLGA loose layer in the PLGA double-layer fiber membrane carries second sodium hyaluronate particles loaded with a bone regeneration promoting medicine, and the second sodium hyaluronate particles can promote osteoblast adhesion and facilitate dentale regeneration when making contact with bone tissue.

The invention discloses an intelligent wound dressing for matrix metalloproteinase detection and administration and application. The intelligent wound dressing comprises biological sensitive hydrogel, an electrode packaging layer, a flexible interdigital electrode, a device packaging layer, a signal transmission antenna and a skin adhesion layer. The bio-sensitive hydrogel is used for biologically recognizing matrix metalloproteinase and carrying and controlled release of antibacterial drugs, and the flexible interdigital electrode and the signal transmission antenna are electrically connected through welding and used for data collection and transmission. The concentration of matrix metalloproteinase in a wound is dynamically detected through biological sensitive hydrogel and a wireless passive radio frequency technology, the inflammation condition of the wound is reflected in real time, silver nanoparticles are delivered according to needs for bacteriostatic treatment, and therefore closed-loop management of the wound is achieved, and the wound healing effect is improved. And a personalized detection and treatment integrated platform is provided for chronic wounds.

The invention provides a drug-loaded intravascular stent and a preparation method thereof.The preparation method of the drug-loaded intravascular stent comprises the steps that drug-loaded microspheres are prepared; wherein the drug-loaded microspheres comprise chitosan nanoparticles loaded with an anti-inflammatory drug, an antibacterial drug layer coating the chitosan nanoparticles, and a PLGA (poly (lactic-co-glycolic acid)) shell layer coating the antibacterial drug layer; mixing the drug-loaded microspheres with PLGA (poly (lactic-co-glycolic acid)) microspheres to prepare a blended wire rod; and according to a digital model, carrying out 3D printing on the blended wire rod to form the drug-loaded intravascular stent.

The invention discloses an anti-falling loop ligature ring for promoting blood coagulation, and belongs to the field of medical instruments. The loop ligature ring comprises an inner layer and an outer layer and is made of biocompatible materials, a hollow gap is formed in the tail end of the loop ligature ring, the inner diameter of the loop ligature ring is slightly larger than that of the head end, the inner layer is a degradable layer, multiple medicine components are evenly dispersed in the inner layer, the loop ligature ring can resist inflammation, promote blood coagulation and revascularization, a unique anti-skid structure is designed on the side close to hemorrhoids, the outer layer is an elastic layer, and anti-skid contraction grooves are formed in the outer layer. And the outer surface is coated with an antibacterial agent coating. According to the loop ligature ring, after tissue loop ligature is carried out, formation of blood coagulation in the loop ligature tissue can be promoted, revascularization is inhibited, necrosis and falling of the loop ligature tissue are accelerated, displacement of the loop ligature ring can be prevented, the loosening risk of the loop ligature ring is reduced, loop ligature stability is improved, and a safe, rapid and convenient loop ligature mode is provided for tissue loop ligature.

The present invention relates to a Lactobacillus delbrueckii subspecies and a culture method and application thereof. The Lactobacillus delbrueckii subspecies of the present invention is preserved in the China Center for Type Culture Collection, and its preservation number is CCTCCNO.M20221248. The Lactobacillus delbrueckii subspecies of the present invention is negative in a hydrogen peroxide test, can decompose sucrose and D-glucose, etc.; can produce a-hemolytic rings and antibacterial rings, can inhibit the growth of Staphylococcus aureus and Escherichia coli visible to the naked eye after being cultured on a blood plate for 48 hours, and can produce regular concentric circular hemolytic rings with Staphylococcus aureus; can inhibit the growth of Streptococcus agalactiae by producing acid on a culture medium; can decompose glycogen in vaginal epithelial cells to produce lactic acid, reduce pH value, inhibit the growth of pathogenic bacteria and excessive reproduction of conditional pathogens; is sensitive to 19 common antibacterial drugs, and is only resistant to sulfonamides; is suitable for the prevention or treatment of bacterial vaginal diseases, especially the prevention or treatment of bacterial vaginal diseases in pregnant women.

The invention provides an antibacterial mask, and relates to the technical field of masks. The antibacterial mask comprises a protective layer, a filter layer and a skin-friendly layer which are sequentially arranged from outside to inside; the protective layer is used for blocking large-particle impurities in the external environment; the filter layer is used for filtering one or more harmful substances in the external environment; the skin-friendly layer is used for being in direct contact with the face skin of a wearer; the medicine release device is connected with the protective layer, the medicine release device is provided with at least one medicine release end, the medicine release end penetrates through the protective layer and is arranged between the protective layer and the filter layer, and the medicine release device is used for releasing medicine between the protective layer and the filter layer. According to the technical scheme, new antibacterial drugs can be continuously supplemented to the area between the protective layer and the filter layer, a good antibacterial environment is maintained, the antibacterial effective duration of the mask is effectively prolonged, and the replacement frequency of the mask is reduced.

This invention relates to the field of medical nursing equipment technology, specifically to a wound and stoma infection prevention and care device. It includes a bag body with an adhesive-coated base fixedly connected to it. The base has a slit in its center, and an annular cavity is fixedly connected to the side of the base closest to the skin. The wall of the annular cavity is made of silicone, and several through holes are formed in the inner wall of the annular cavity. Antibacterial medication is placed inside the annular cavity. An absorption component is provided on the base to assist in absorbing exudate and reduce the risk of infection. This invention, by setting a silicone annular cavity containing antibacterial medication on the skin side of the base, in conjunction with the absorbent resin strip component inside the base, achieves targeted release of antibacterial medication for sterilization and active absorption and transfer of exudate, thus reducing the risk of stoma infection through a dual effect.

The present application relates to the technical field of medical devices, in particular to a drug-loaded anastomosis nail processing technology, which comprises the following steps: slotting or drilling is performed on a metal wire by a laser cutting device, and the end of the metal wire is cut into a pointed end structure as a drug-loaded anastomosis nail base; the obtained drug-loaded anastomosis nail base is cleaned; the cleaned drug-loaded anastomosis nail base is fitted and installed on a spraying assembly, and a spraying solution containing an antibacterial drug and a polymer carrier is used to spray the drug-loaded anastomosis nail base under the condition that the spraying assembly drives the drug-loaded anastomosis nail base to rotate; the obtained sprayed drug-loaded anastomosis nail base is formed into a U-shaped nail on a nail forming tool, and the U-shaped nail is the drug-loaded anastomosis nail. The present application is provided with a drug-loading groove on the anastomosis nail, and the drug is sprayed into the drug-loading groove. When the anastomosis nail is used, the drug is continuously released through the nail foot of the drug-loaded anastomosis nail, and the wound healing is accelerated.

A method for constructing a graded limbal injury and repair model comprises: after administering topical anesthetic drops to the operated eye of a model animal, placing a limbal injury device containing a NaOH solution in the limbal area of ​​the model animal for 30 seconds, then removing the device and irrigating the operated eye with saline; postoperatively, administering an antibacterial drug to the operated eye of the model animal several times daily; and eight days after surgery, a graded limbal injury and repair model is obtained, wherein the limbal injury device applies alkali burns of varying sizes to the limbal area, thereby achieving a graded injury effect. The construction method provided by the present invention has been shown to be simple, laboratory-friendly, inexpensive, short, and reproducible, with quantifiable evaluation methods, making it an ideal method for constructing an animal model of limbal stem cell injury.

The present application belongs to the technical field of medical stents, and particularly relates to a drug-loaded polydopamine hydrogel filled polycaprolactone stent and a preparation method and application thereof. The polycaprolactone stent comprises a polycaprolactone stent body, and drug-loaded mesoporous ceramics and zeolite imidazolate framework material embedded in the polycaprolactone stent body; the drug-loaded mesoporous ceramics are embedded in the zeolite imidazolate framework material; the matrix material of the polycaprolactone stent body is polycaprolactone, the micropore structure between fibers and the surface of the fibers of the polycaprolactone has a micropore structure, and the size of the micropore structure between the fibers is greater than that of the surface of the fibers; the micropore structure is filled with drug-loaded polydopamine hydrogel. The polycaprolactone stent has good porosity, biocompatibility and antibacterial property, can induce stem cell osteogenic differentiation, can accelerate the release of antibacterial drugs in the case of infection, and the internally encapsulated drugs for promoting tissue regeneration and repair can be slowly released, and is suitable for the repair and regeneration of infected bone tissue defects.

The invention provides a topologically optimized alloy ocular prosthesis structure, and relates to the technical field of ocular prosthesis structures, the topologically optimized alloy ocular prosthesis structure comprises an ocular prosthesis table body and a positioning hole, and the ocular prosthesis table body is made of a titanium alloy material through a 3D printing technology; the shape of the alloy prosthetic eye is matched with the shape of a human body muscular cone cavity, and the alloy prosthetic eye comprises a base which is used for being fixedly implanted into an eye socket; micropores are formed in the surface of the ocular prosthesis table body and used for promoting tissue fibrosis and new blood vessel generation. The surface of the ocular prosthesis table body is subjected to anodic oxidation and electrochemical polishing, and the surface of the ocular prosthesis table body is coated with a bioactive coating; the drug sustained-release through holes are formed in the artificial eye table body and used for slowly releasing anti-inflammatory or antibacterial drugs, a Ti-6Al-4V or similar titanium alloy material is adopted, anodic oxidation and electrochemical polishing treatment are combined, a uniform and stable titanium oxide layer is formed, the biocompatibility of the artificial eye table is effectively improved, and tissue rejection reaction is reduced.

The present invention relates to the technical field of bone scaffolds, and more specifically, to a bone scaffold composite material, a preparation method thereof, and a bone scaffold. The bone scaffold composite material prepared by the present invention has a layered structure, wherein the inner layer is a porous material loaded with a bone tissue repair-promoting drug, the middle layer is a polydopamine layer, and the outer layer is in situ grown Ag particles (antibacterial drugs). The material can be used to make a bone scaffold. In the prepared bone scaffold, the polydopamine layer plays a role in isolating the bone tissue repair-promoting drug and the antibacterial drug, thereby preventing the bone tissue repair-promoting drug and the antibacterial drug from reacting with each other and failing. Since the porous material loaded with the bone tissue repair-promoting drug is located in the inner layer, it can ensure that the bone tissue repair-promoting drug is released after the antibacterial drug is released. The bone scaffold provided by the present invention has an adjustable elastic modulus that can match the mechanical strength of human cancellous bone.

The present application discloses a three-dimensional stent, a preparation method therefor, and use thereof. Starting materials for preparing the three-dimensional stent provided by the present application include a carbon-inorganic oxide hybrid micro-nanofiber and carrageenan. The three-dimensional stent provided by the present application not only enables photo-thermal treatment, photo-thermal antibacterial effects, controlled drug release, and bone repair, but also has excellent biocompatibility and biological activity.

The invention belongs to the technical field of medical chemistry, and discloses an aminoacridine compound with multiple electron withdrawing substituents, which has broad-spectrum antibacterial activity and can quickly sterilize, and a preparation method and application thereof. The compound is prepared through Ullmann coupling reaction, ring closing reaction and ammonolysis reaction, and the structure of the compound is shown as a formula I-a formula III. Bacteriostatic activity experiment research shows that the compound has definite bacteriostatic activity to various cocci and bacilli, the minimum inhibitory concentration (MIC) to staphylococcus aureus and staphylococcus epidermidis reaches 0.25 mu g / mL, and the minimum inhibitory concentration (MIC) to staphylococcus capitis can reach 0.5 mu g / mL. The compound can be used for developing antibacterial drugs, and has the advantages of high antibacterial activity, wide antibacterial spectrum, rapid sterilization and the like. And # imgabs0 #.

The invention provides an antibacterial drug-hydrogel composite dressing for nursing pressure sores and a preparation method thereof. The dressing is formed by compounding a surface layer, a middle antibacterial hydrogel layer and a bottom layer, the middle layer takes a carboxymethyl chitosan-polyacrylic acid copolymer as a matrix and is loaded with an antibacterial agent compounded by surface modified nano zinc oxide and polyhexamethylene biguanide hydrochloride and a healing promoting component compounded by recombinant human epidermal growth factors and aloe polysaccharide. The preparation process comprises the steps of nitrogen protection, standing curing and the like, and the process is controllable. Tests show that the dressing has an antibacterial rate of more than or equal to 99.2%, excellent air permeability and water absorption performance, a wound healing time shortening rate of more than or equal to 38%, and good fitness and biocompatibility which are obviously superior to those of a contrast, can be adapted to I-IV stage pressure sore nursing, is suitable for hospitals, families and other scenes, has good clinical application value, and can be produced on a large scale.

The synergistic antibacterial auricular point patch comprises a fixed layer, a first fiber membrane layer, a second fiber membrane layer and an acupoint stimulation part, a first cavity is formed between the first fiber membrane layer and the fixing layer, and a medicine for promoting qi to activate blood is loaded in the first cavity; the second fiber membrane layer is arranged on the periphery of the first fiber membrane layer in a concentric-square-shaped surrounding mode. A second cavity is formed between the second fiber membrane layer and the fixing layer, and an antibacterial medicine is loaded in the second cavity; a first mounting hole of the first fiber membrane layer is matched with an acupoint stimulation component, the upper end of the acupoint stimulation component penetrates through the first mounting hole and then is fixedly connected with the surface of the side, facing the ear skin, of the fixing layer, and the lower end of the acupoint stimulation component is higher than the lower end of the first fiber membrane layer. Therefore, the design reduces the risk of skin infection while enhancing the conditioning effect.