7 results about "Antiseptic medication" patented technology

The invention provides a hinokitiol-dihydromyricetin composite nano condensation body and a preparation method and application thereof, and the composite nano condensation body comprises the following components in 100 mL of a suspension: 0.3 to 0.5 g of hinokitiol, 0.5 to 0.8 g of dihydromyricetin, 1.0 to 1.5 g of chitosan, 0.5 to 0.8 g of sodium alginate, 2.0 to 3.0 mL of polyethylene glycol, 0.3 to 0.5 mL of Tween, 1.0 to 1.5 mL of glycerol, and the balance of a citric acid-sodium citrate buffer solution. The invention provides a hinokitiol-dihydromyricetin composite nano-coacervate which can synchronously solve the problems of synergistic bacteriostasis, membrane rupture and antibiosis, anti-inflammatory repair, application defects of active ingredients and the like of common animal skin antibacterial drugs. The preparation method of the composite nano coacervate is simple, large-scale production is easy, complex equipment is not needed, it can be ensured that active ingredients of a finished product are evenly distributed, the composite nano coacervate can penetrate through the skin cuticle and can also penetrate through a bacterial biofilm, and the synergistic effect is fully achieved.

The utility model provides a fibrous membrane for guiding periodontal tissue regeneration, and relates to the technical field of medical instruments. Preparing a PLGA double-layer fiber membrane loaded with drug-loaded sodium hyaluronate particles through the cooperative work of electrostatic spinning and electrostatic spraying; the sodium hyaluronate particles can greatly improve the loading rate of hydrophilic anti-inflammatory antibacterial and bone regeneration promoting medicines; a PLGA compact layer in the PLGA double-layer fiber membrane is loaded with first sodium hyaluronate particles loaded with anti-inflammatory and antibacterial drugs, and when the first sodium hyaluronate particles make contact with gingival tissue, cell adhesion and permeation can be hindered, and the anti-inflammatory and antibacterial effects can be achieved; a PLGA loose layer in the PLGA double-layer fiber membrane carries second sodium hyaluronate particles loaded with a bone regeneration promoting medicine, and the second sodium hyaluronate particles can promote osteoblast adhesion and facilitate dentale regeneration when making contact with bone tissue.

The invention provides a drug-loaded intravascular stent and a preparation method thereof.The preparation method of the drug-loaded intravascular stent comprises the steps that drug-loaded microspheres are prepared; wherein the drug-loaded microspheres comprise chitosan nanoparticles loaded with an anti-inflammatory drug, an antibacterial drug layer coating the chitosan nanoparticles, and a PLGA (poly (lactic-co-glycolic acid)) shell layer coating the antibacterial drug layer; mixing the drug-loaded microspheres with PLGA (poly (lactic-co-glycolic acid)) microspheres to prepare a blended wire rod; and according to a digital model, carrying out 3D printing on the blended wire rod to form the drug-loaded intravascular stent.

This invention relates to the field of medical nursing equipment technology, specifically to a wound and stoma infection prevention and care device. It includes a bag body with an adhesive-coated base fixedly connected to it. The base has a slit in its center, and an annular cavity is fixedly connected to the side of the base closest to the skin. The wall of the annular cavity is made of silicone, and several through holes are formed in the inner wall of the annular cavity. Antibacterial medication is placed inside the annular cavity. An absorption component is provided on the base to assist in absorbing exudate and reduce the risk of infection. This invention, by setting a silicone annular cavity containing antibacterial medication on the skin side of the base, in conjunction with the absorbent resin strip component inside the base, achieves targeted release of antibacterial medication for sterilization and active absorption and transfer of exudate, thus reducing the risk of stoma infection through a dual effect.

The present application relates to the technical field of medical devices, in particular to a drug-loaded anastomosis nail processing technology, which comprises the following steps: slotting or drilling is performed on a metal wire by a laser cutting device, and the end of the metal wire is cut into a pointed end structure as a drug-loaded anastomosis nail base; the obtained drug-loaded anastomosis nail base is cleaned; the cleaned drug-loaded anastomosis nail base is fitted and installed on a spraying assembly, and a spraying solution containing an antibacterial drug and a polymer carrier is used to spray the drug-loaded anastomosis nail base under the condition that the spraying assembly drives the drug-loaded anastomosis nail base to rotate; the obtained sprayed drug-loaded anastomosis nail base is formed into a U-shaped nail on a nail forming tool, and the U-shaped nail is the drug-loaded anastomosis nail. The present application is provided with a drug-loading groove on the anastomosis nail, and the drug is sprayed into the drug-loading groove. When the anastomosis nail is used, the drug is continuously released through the nail foot of the drug-loaded anastomosis nail, and the wound healing is accelerated.

The invention provides an antibacterial drug-hydrogel composite dressing for nursing pressure sores and a preparation method thereof. The dressing is formed by compounding a surface layer, a middle antibacterial hydrogel layer and a bottom layer, the middle layer takes a carboxymethyl chitosan-polyacrylic acid copolymer as a matrix and is loaded with an antibacterial agent compounded by surface modified nano zinc oxide and polyhexamethylene biguanide hydrochloride and a healing promoting component compounded by recombinant human epidermal growth factors and aloe polysaccharide. The preparation process comprises the steps of nitrogen protection, standing curing and the like, and the process is controllable. Tests show that the dressing has an antibacterial rate of more than or equal to 99.2%, excellent air permeability and water absorption performance, a wound healing time shortening rate of more than or equal to 38%, and good fitness and biocompatibility which are obviously superior to those of a contrast, can be adapted to I-IV stage pressure sore nursing, is suitable for hospitals, families and other scenes, has good clinical application value, and can be produced on a large scale.

The synergistic antibacterial auricular point patch comprises a fixed layer, a first fiber membrane layer, a second fiber membrane layer and an acupoint stimulation part, a first cavity is formed between the first fiber membrane layer and the fixing layer, and a medicine for promoting qi to activate blood is loaded in the first cavity; the second fiber membrane layer is arranged on the periphery of the first fiber membrane layer in a concentric-square-shaped surrounding mode. A second cavity is formed between the second fiber membrane layer and the fixing layer, and an antibacterial medicine is loaded in the second cavity; a first mounting hole of the first fiber membrane layer is matched with an acupoint stimulation component, the upper end of the acupoint stimulation component penetrates through the first mounting hole and then is fixedly connected with the surface of the side, facing the ear skin, of the fixing layer, and the lower end of the acupoint stimulation component is higher than the lower end of the first fiber membrane layer. Therefore, the design reduces the risk of skin infection while enhancing the conditioning effect.