43results about How to "No obvious irritation" patented technology

The invention relates to compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and a preparation method thereof. The compound formula mouth wash comprises the following main raw materials: chlorine dioxide, cetylpyridinium chloride and zinc ions, wherein a solvent is distilled water; the concentration of the chlorine dioxide is 200-500 ppm; the cetylpyridinium chloride accounts for the mass fraction of 0.05-0.2 percent relative to the compound formula mouth wash; and the zinc ions accounts for the mass fraction of 0.5-1 percent relative to the compound formula mouth wash. The preparation method of the compound formula mouth wash comprises the following steps of: dissolving the cetylpyridinium chloride and zinc acetate into the distilled water; dissolving a menthol crystal into 95 percent of ethanol; adding a menthol crystal and ethanol solution to a water solution for stirring, and simultaneously adding glycerol; additionally dissolving chlorine dioxide powder into the distilled water; adding a chlorine dioxide water solution to the water solution while stirring; uniformly stirring, and adding the distilled water to obtain the compound formula mouth wash of the chlorine dioxide, the cetylpyridinium chloride and the zinc ions. The invention can effectively inhibit bromopnea for a long time and has fewer side effects and no obvious irritation on an oral mucosa.

The invention belongs to the technical field of health disinfection, and discloses a composite bactericide. The composite bactericide comprises, by weight, 15 to 30% of a single chain quaternary ammonium salt, 25 to 40% of a double chain quaternary ammonium salt, 0.1 to 5% of a phenol bactericide, 2 to 10% of a nonionic surfactant, and the balance deionized water. The invention also discloses a preparation method and applications of the composite bactericide. Synergistic interactions of the ingredients are realized, mutual promoting effect is achieved, sterilizing effect is improved obviously,sterilizing speed is accelerated, using concentration is lower, the composite bactericide is nontoxic, no irritation is caused, storage is stable, the composite bactericide is safe and green, and isfriendly to the environment. Operation of the preparation method is convenient, and industrialized production can be realized easily.

This application discloses a pharmaceutical composition including a sedative and a narcotic. The pharmaceutical composition is suitable for a programmed controlled release drug delivery preparation indigestive endoscopic diagnosis and treatment, can be a nasal microsphere preparation containing the sedative and the narcotic. The sedative is quickly released and can relieve tension, anxiety and fear in patients firstly. The anesthetic wrapped in microspheres works later and can maintain anesthesia to facilitate checking. The preparation not only increases the compliance of a patient, but alsois given more conveniently, saves the diagnosis time, and improves the treatment efficiency.

The invention provides a nano glass antifogging agent and a preparation method thereof. The nano glass antifogging agent comprises effective components and water. The effective components comprise an anionic surfactant, a non-ionic surfactant, a nano photocatalytic active substance, an active agent stabilization additive, an organic acid solvent and a volatilization dispersant. In the preparation process, the organic acid solvent and the volatilization dispersant are mixed with partial water so as to obtain solution A; the anionic surfactant is mixed with the non-ionic surfactant so as to obtain solution B; the active agent stabilization additive is added to the solution B, the solution is uniformly mixed, then the solution A is added, and the rest water is added after uniformly mixing, the nano glass antifogging agent is obtained after uniformly mixing. The preparation method is capable of stably dispersing the nano photocatalytic active substance into a carrier solvent, using the super-hydrophilic property and nano adhesiveness thereof, and using own specific ultraviolet shielding and the decomposing and removing of harmful gases in the air as the function extension of the nano glass antifogging agent, and obtaining the nano glass antifogging agent with the long-term stable antifogging effect and the possible functional recovery after long-term use.

The invention discloses a composition for treating infantile eczema, a preparation, a preparation method of the preparation, and an application of the pcomposition. The preparation comprises an activeingredient D, a component A, a component B and component C; the active ingredient D comprises, by weight, 1 part of a pitera fermentation product filtrate and 0.45 part of plant extract; and the component A comprises 0.06 part of EDTA-2Na, 3 parts of glycerin, 2 parts of butanediol, 0.03 part of xanthan gum, 0.02 part of low acyl gellan gum, 0.02 part of high acyl gellan gum and 90 parts of water. The piter fermentation product is combined with traditional Chinese medicine components having the efficacy of clearing heat and drying dampness to uniformly act on the eczema part of skins in orderto make the skins fully absorb medicines, so local vasoconstriction, congestion reduction and inflammation reduction are achieved, thereby symptoms of eczema are treated or alleviated.

The invention belongs to the technical field of medicine compositions, and discloses an external use medicine composition used for treating alopecia. The external use medicine composition comprises annular adrenocorticotrophic hormone release factor (CRF) antagonism peptide astressin B in effective treatment amount or acceptable salt on the pharmacy. The external use medicine composition is in a gel dosage form preferably and suitable for clinic use and industrialization production. In addition, the invention further discloses a method for preparing the external use medicine composition and application of the astressin B in effective treatment amount or the acceptable salt on the pharmacy to preparing the external use medicine composition used for treating the alopecia. According to the external use medicine composition, the problem of the alopecia for a long time can be effectively treated; and the external use medicine composition is safe, reliable, free of obvious skin irritants and free of sensitization.

The invention relates to the field of pharmaceutical technology, particularly to a spray for treating diseases caused by human papilloma viruses and a preparation method. The spray comprises, by volume ratio, 1 ml of rabies purified vaccine for human use and 9 ml of chitosan-acetic acid solution with a prepared mass volume concentration being 0.01 g/ml to 0.03 g/ml, wherein the chitosan-acetic acid solution is prepared by fully dissolving 10g to 30g chitosan and the acetic acid solution until the volume reaches 1000 ml. The preparation method comprises the steps of first preparing 0.3% to 1.0% of the acetic acid solution and then preparing the chitosan-acetic acid solution; adding 1 part of the rabies purified vaccine for human use with an active content being 5 IU to 20 IU by volume to a measuring flask with a volume of 10 parts, adding the chitosan-acetic acid solution, and diluting for preparing the vaccine solution. The spray and the preparation method thereof in the invention is focused on follow-up treatments (Tc subgroup detection, HPV detection and improvement of clinical symptoms) of cervical carcinoma patients infected by HPV, HPV-infected people, and venereal diseases, cervical erosion and chronic cervicitis caused by HPV infection, and achieves good clinical results.

The invention discloses a method for producing flavouring lotion by using saccharomycopsis fibuligera. The method comprises the following steps of slant culture: saccharomycopsis fibuligera FBKL 2.0094 is inoculated on a slant culture medium for culturing at 28 DEG C for 24 to 48 hours until hyphae grow fully in a test tube; strains are activated; a seed solution is prepared; solid state fermentation is performed in a triangular flask and a fermented product is obtained; preparation of the flavouring lotion: 26.47 percent of salt solution, 10 percent v/v of ethanol solution and the fermented product are mixed by a ratio of 1 ml:1 ml:1g; the mixture is evenly stirred and the stirring time is 5 to 10 minutes; the stirred mixture is put into a water bath kettle with the temperature of 50 DEG C to be subjected to water bath for 30 minutes; air distillation is performed and the temperature is controlled at 100 DEG C; the timing is started when cut fraction is distilled off; the distillation time is 20 to 40 minutes; 25 to 75 ml of cut fraction is collected into a volumetric flask, and the volumetric flask is subjected to cold storage at 4 DEG C in a refrigerator. The method for producing flavouring lotion by using saccharomycopsis fibuligera provided by the invention is short in production cycle, high in quality rate, and low in production cost.

The present invention discloses a Chinese medicine suppository for effectively curing cervicitis and cervical erosion and its preparation method. Said suppository is formed from active component, matrix and additive.

The invention relates to a method for preventing and treating viral respiratory diseases by atomizing an iodine-containing disinfectant, which can be widely applied to prevention and treatment of viral pneumonia, viral influenza and cold, and particularly has special significance for preventing and treating respiratory system virus infection. In 2019, a paper published by a German scientist in loimology pointed out: the infectious disease can be resisted by iodophor, an iodophor mouthwash can remarkably reduce the virus load of the oral cavity and oropharynx, and infection of two coronaviruses, namely SARS and MERS can be effectively resisted. Based on the particularity of human lung and respiratory tract structures, the invention is designed according to the thought that the human lung and respiratory tract are regarded as special organs which are relatively open to the outside, and most viruses are sensitive to iodine. Firstly, iodine-containing liquid (preferably iodophor) is atomized, then inhaled through the mouth and the nose, sequentially passes through the throat and the trachea and then enters the lung of the human body, and the purpose of inhibiting or killing viruses inpulmonary alveoli and respiratory tracts is achieved. The method is also suitable for daily virus defense of healthy people.

The invention discloses oxygen-rich and temperature-sensitive hydrogel and a preparation method thereof. The oxygen-rich and temperature-sensitive hydrogel is prepared by mixing a CS acid solution, abeta-G solution, an HEC solution and perflubron emulsion; the content of perflubron in the hydrogel is 5.0-15.0vol%. The oxygen-rich and temperature-sensitive hydrogel provided by the invention is free from toxic and side effects, has good physical and chemical properties, oxygen release performance and microstructure, is good in histocompatibility, can be completely removed by metabolism, can promote bone defect healing, and is suitable for being used in the field of bone tissue engineering as a sustained-release carrier of oxygen. The oxygen-rich and temperature-sensitive hydrogel has the basic biological characteristics of CS, is experimentally proved to have good histocompatibility and degradability, has no obvious stimulation and toxic and side effects on surrounding tissues, and canbe gradually and completely eliminated by means of metabolism; the degradation process can provide a growth space for the new bone tissues, so that bone healing is promoted.

The invention discloses a preparation process of a cleaning fluid for liquid crystal display screen thinning. The preparation process comprises the following steps: S1, selecting raw materials; S2, preparing an auxiliary emulsifier; S3, preparing a cleaning aid liquid; and S4, preparing a waterborne cleaning fluid. The preparation process of the cleaning fluid for liquid crystal display screen thinning is characterized in that a cationic surfactant as a cationic emulsifier and an auxiliary emulsifier which is prepared as a nonionic emulsifier by adding a short-carbon-chain isomeric fatty alcohol polyether to a compound of isomeric alcohol ethoxylate 1309L and linear alcohol ethoxylate AEO-9 are mixed with water, and then added with additives and the cleaning aid to obtain the waterborne cleaning fluid; and the waterborne cleaning fluid has excellent cleaning and emulsifying effects on residual liquid crystals on a liquid crystal display screen with a good cleaning decontamination rate,is non-corrosive to a liquid crystal display screen glass sealant, and has a good cleaning effect on residual glass scraps, finger marks, dust and other dirt on display screen glass.

The invention relates to a neostigmine methylsulfate frozen-dried preparation for injection and a preparation method of the neostigmine methylsulfate frozen-dried preparation. Neostigmine methylsulfate injection is instable when meeting light and heat, and a mainly degradation impurity namely 3-hydroxy tricresylamine neostigmine methylsulfate has a genotoxicity warning structure. In order to improve stability, the inventor improves the preparation formulation, and the frozen-dried preparation is prepared. Through recipe screening and process improvement, the frozen-dried preparation product isobtained. The obtained product is good in appearance, good in redissolution properties and good in clarity, and the main degradation impurity namely 3-hydroxy tricresylamine neostigmine methylsulfateis greatly reduced, so that the product safety and stability are improved.

The invention relates to a composition for treating and preventing alopecia. The composition comprises 1-10 parts of ginger, 0.5-2 parts of musk, 0.5-2 parts of bezoar, 0.5-3 parts of epimedium herb, 0.5-2 parts of sandalwood, 0.5-5 parts of astragalus root, 0.5-5 parts of licorice extract, 0.5-5 parts of root-bark of peony tree, 0.5-10 parts of angelica root, 0.5-10 parts of root of red-rooted salvia, 0.5-10 parts of Chinese magnoliavine fruit, 5-10 parts of fleeceflower root, 0.5-10 parts of cypress leaf, 0.5-10 parts of dried rehamnnia root, 0.5-2 parts of mint, 0.5-10 parts of stem of false tomentoseanther clematis, 0.5-10 parts of saffron, 0.5-2 parts of vitamin E, 0.5-1 part of cimetidine, 0.1-2 parts of capsicum tincture and 0.1-2 parts of penetration enhancer. The composite has no evident simulation and is applicable to the treatment of madarosis and sparse eyebrows and eyelashes; 1670 clinical cases show that significant efficiency in 1515 cases continuously tracked is 95.7%; the composition has no toxic and side effects and is suitable for continuous application.

The invention provides a nasal gastrodin pharmacia with biological adhesion characteristic. The nasal gastrodin pharmacia is prepared through the following steps: preparing an aqueous sodium hydroxide solution of starch as a water phase; dispersing gastrodin in ethyl acetate to prepare an oil phase; slowly adding the oil phase into the water phase at room temperature, and equidirectionally stirring to obtain O/W colostrum; and heating liquid paraffin containing Span80 to 40-50DEG C, adding the O/W colostrum, equidirectionally for emulsifying for 20-40min, adding a cross-linking agent chloropropylene oxide, crosslinking at 30-50DEG C for 3-5h, centrifuging, pouring off the above obtained upper layer oil phase, respectively washing the above obtained lower layer microsphere by ethyl acetate, anhydrous ethanol and acetone, and carrying out reduced pressure drying. The nasal gastrodin pharmacia has the advantages of long nasal cavity detention time, stable and complete drug release, improvement of the drug distribution in brain, the bioavailability and the drug effect, safety and non-toxicity.

The invention discloses a composition for treating oral diseases and a preparation method of the composition. The composition is mainly prepared from the following components: chlorine dioxide, cetyl pyridinium chloride and zinc ions, wherein the solvent is distilled water, the concentration of chlorine dioxide is 200-500 ppm, the weight of cetyl pyridinium chloride accounts for 0.05-0.2 % of that of compound mouthwash, and the weight of zinc ions accounts for 0.5-1 % of that of the compound mouthwash. The preparation method of the composition comprises the following steps: dissolving cetyl pyridinium chloride and zinc acetate in the distilled water, dissolving menthol in 95% alcohol, adding the menthol alcohol solution into an aqueous solution, carrying out stirring, and meanwhile, adding with glycerinum; taking chlorine dioxide powder, dissolving the chlorine dioxide powder in distilled water, adding the chlorine dioxide aqueous solution into aqueous solution under stirring, carrying out uniform mixing, and adding with distilled water, thus obtaining the composition for treating oral diseases. The composition has the advantages that the mouth odor can be inhibited for a long term, the side effects are small, and no obvious irritation is caused to the oral mucosa.

The invention relates to an oral spray used for cancer patients, and relates to the technical field of oral care. The oral spray is prepared from the following components in percentage by weight: 2% to 15% of a sugar alcohol humectant, 2% to 16% of a forsythia fruit extract, 2% to 10% of a stevia rebaudianum extract, 2% to 10% of a propolis extract, 1% to 10% of a blueberry extract, 0.2% to 10% of a solubilizer, 0.2% to 2% of thymol crystals, 0.7% to 10% of a metal astringent, 0.5% to 5% of a preservative, 0.05% to 4% of guaiazulene sodium sulfonate, 0.1% to 2.5% of poloxamer, 0.7% to 9% of an acidity regulator and the balance of deionized water. The oral spray disclosed by the invention is safe, and free of obvious stimulation or side effect, has the effects of relieving pain, inhibiting bacteria, resisting viruses and eliminating free radicals, and is capable of relieving oral inflammatory reactions caused by chemoradiotherapy, relieving pains caused by oral mucosa damage and promoting oral mucosa repair.

The invention discloses electuary for treating bile reflux gastritis. The electuary comprises the following raw materials: rhizoma kaempferiae, rhizoma nardostachyos, garden burnet, smoked plum, hedyotis diffusa, inula forrestii, dutchmanspipe roots, sargent gloryvine, spina date seeds, rhizoma polygonati, moutan bark, leaves and stems of true indigo, ginseng flower, radix achyranthis bidentatae and assistant materials. The electuary disclosed by the invention has the functions of soothing the liver and regulating qi, harmonizing the stomach for descending adverse qi, clearing heat and promoting dieresis, clearing gallbladder and harmonizing the stomach, tonifying spleen and reinforcing the stomach as well as clearing dampness and removing stasis, the clinical observation result shows that the formula not only can improve peristole and promote gastric emptying, but also can recover the pylorus sphincter function, can prevent bile from refluxing, has the effects of promoting gastric mucosa remediation, is remarkable in treatment effect on bile reflux gastritis, and is convenient to take, and moreover the purpose of treating bile reflux gastritis by easily treating both symptoms and root causes by using the electuary in daily life can be achieved.