110results about How to "Reduced metabolic activity" patented technology

The invention belongs to the field of biomedical materials and particularly relates to a preparation method of a co-crosslinked double-network hydrogel support for promoting cartilage repair and growth. The method comprises the following steps of (1) preparation of GelMA; (2) preparation of a photo-crosslinked polypeptide; and (3) preparation of a hydrogel support, namely preparing the hydrogel support from the GelMA and the photo-crosslinked HSNGLPL under the action of a photoinitiator. The prepared hydrogel support has an obvious effect of promoting new cartilage generation and cartilage defect healing, and is capable of regulating cartilage matrix secretion of normal chondrocytes around the injured tissue, mesenchymal stem cell migration to the injured part and cartilage differentiation; by virtue of a porous structure of the hydrogel support, the HSNGLPL can be crosslinked to the surface of a porous support, endogenous TFG-beta is effectively adsorbed, the concentration of local TFG-beta beta1 is improved and the effects of the biological support in the orthopedics fields, such as a cartilage defect and a cartilage injury are achieved.

The present disclosure relates to enhanced nitrification inhibitor dry fertilizer compositions, methods for making the same, and their use in agricultural applications.

The invention belongs to the technical field of fertilizer, and more specifically relates to a tobacco special-purpose charcoal-based compound fertilizer, and a preparation method and an application method thereof. The tobacco special-purpose charcoal-based compound fertilizer comprises, by weight, tobacco straw, waste tobacco, pig manure, earthworm manure, vegetable waste, domestic garbage, nitrogen fertilizer, phosphate fertilizer, potassium fertilizer, trace element liquid fertilizer, a compound microbial agent, and an adhesive, and is prepared through a plurality of technologies. The tobacco special-purpose charcoal-based compound fertilizer is high in granulation rate, is capable of obviously improving fertilizer utilization rate, and is capable of improving soil acidifying and hardening after being applied to tobacco field, and increasing soil available nutrient content; the quality of the harvested tobacco leaves is improved obviously, the proportion of middle and upper-grade tobacco leaves is increased, the yield per mu and the output value per mu are obviously increased; and the tobacco special-purpose charcoal-based compound fertilizer is taken as a base fertilizer, onlyone time of application is capable of satisfying all the requirements of tobacco on nutrients in the tobacco growth period, reducing the using amount and the application frequency of traditional fertilizers; using is convenient; and labor is saved.

Processes are disclosed for preparing microorganism concentrates from fermentation broth containing a free suspension of the microorganisms which is used for the anaerobic conversion of syngas to oxygenated organic compound. The processes involve the use of processing steps and the presence of certain additives to enhance the ability of the microorganism concentrate to be stored for extended periods and reactivated.

The present invention provides, in part, methods for treating a tumor in a human subject comprising inhibiting IGF-1 receptor signaling, methods of determining whether a tumor is more or less likely to respond to such treatment, and compositions for practicing such methods. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.

The present disclosure relates the enhanced nitrification inhibitor compositions, methods for making the same, and their use in agricultural applications.

The invention discloses a transport case for aquatic products. The transport case comprises a cover, a metal trunk and an ice block box. On the cover of the transport case, ice blocks can be arranged in the ice block box, so that the temperature in the case can be reduced, the aquatic products can conveniently survive at a relatively low temperature, the metabolic activities of the aquatic products are reduced, and long-term survival of the aquatic products is promoted. A magnet is arranged at the bottom of the case, so that the trunk at the bottom of a truck is attracted by the magnet, the condition that the cases are moved in the vehicle so as to be collided with one another due to sudden acceleration or sudden brake of the vehicle is avoided, and the survival rate of the aquatic products is guaranteed. Due to springs and sponges in the cases, vibration and impact of outside on the cases can be buffered, and the survival rate of the aquatic products in the transport process is improved. An inner cylinder is arranged in the case, and when a user needs to change water or needs to totally take the aquatic products in the case out, the inner cylinder can be directly taken out of the inner case, and the water flows out through a net at the bottom of the inner cylinder, so that the labor force is reduced.

The invention discloses a method for prolonging fresh keeping time of vegetables by combination of ultrasonic wave composite ozone water and controlled atmosphere, and belongs to the technical field of storing and fresh keeping of agriculture products. The method comprises the following steps of selectively picking fresh vegetables, performing sorting, performing fresh keeping through combinationof ultrasonic wave composite ozone water and controlled atmosphere, and during the storage mid period, performing treatment with ozone gas treatment to perform coprocessing on the vegetables for freshkeeping, so as to prolong the storage period. According to the method, quality and nutrient components of the vegetables during the storage period can be well maintained, the storage period of the vegetables can be prolonged to 60 days, and the method is suitable for oversea sail, so that the inconvenience and the cost of side dish during halfway for oversea ships can be greatly saved.

The invention relates to lactobacillus bulgaricus with low beta-galactase activity and application thereof. The lactobacillus bulgaricus is classified and named as lactobacillus delbrueckii subsp. bulgaricus, and the microbial preservation number is CGMCC No.9957. The strain is screened from the lactobacillus bulgaricus separated from a traditional milk product and has relatively stable performance, the instability, caused by overmuch passage number, similar to mutant strains is avoided, and furthermore, weak post-acidification capacity can be preserved all the time, so that the post-acidification of yoghourt in a preservation period can be effectively delayed in the actual application, and the shelf life of the yoghourt can be prolonged; furthermore, the strain has an excellent fermentation property and can be used as a weak post-acidification yoghourt fermentation agent to be applied to industrialization.

The present invention is directed to preferred pharmaceutical compositions comprising sibutramine and rimonabant and use of sibutramine and rimonabant to treat obesity and obesity related disorders in a patient.

The invention belongs to the biological field, and relates to single base mutation of the 1735th locus of CYP2D6 allele. The locus is mutated into C from G. The invention concretely relates to a nucleic acid segment containing the mutation locus, a corresponding coded protein fragment, agents for identification of the mutation locus, a detection method and applications of the locus, especially applications of the identification of the locus in medication guidance.

There is described a method of reducing or preventing the agglomeration of spheroids comprising the use of a cell culture device comprising: a cell culture chamber comprising a base and side walls extending from the base to enclose a volume of the cell culture chamber; an inlet in the base or side walls of the cell culture chamber adapted for fluid communication into the chamber; and an outlet in the base or side walls of the cell culture chamber adapted for fluid communication out of the chamber; wherein the base of the cell culture chamber comprises a discontinuous surface adapted to reduce or prevent the agglomeration of spheroids.

The invention discloses a method for corn seed priming. The method comprises the following steps: selecting corn seeds and treating the seeds with disinfection, cleaning and drying; dissolving polyamine in water to obtain a polyamine aqueous solution, and making a treating fluid after mixing; adding the treating fluid to the corn seeds and conducting low-temperature priming; and cleaning and re-drying the corn seeds which are already primed, and conducting sowing or low-temperature storage. The method is easy to operate and master and short in duration, and can promote germination and growth of seedlings and enhance cold resistance in case of low temperatures after corn sowing.

The invention belongs to the field of biology and relates to a single base mutant at the 3334th site of CYP2D6 allele, wherein G at the site is mutated into A. The invention particularly relates to a nucleic acid segment containing the mutant site and a corresponding protein segment coded by the nucleic acid segment, a reagent and detection method for identifying the mutant site, application of the site, and especially application of identification of the site in medicine instruction.

The present disclosure relates to an improved nitrification inhibitor composition and its use in agricultural applications.

The invention discloses a health care product used for smokers. The health care product used for smokers consists of agilawood, sandalwood, citron and root of kudzu vine. The materials are cleaned to remove impurities, dried, crushed into 80-150 meshes, and decocted for 2 hours-3 hours by adding water 8-10 times the amount of the total materials, and decoction is collected to obtain the health care product. The health care product used for smokers is used for treating halitosis, bitter taste, pharyngitis, parageusia, cough with excessive phlegm, and trachitis caused by smoking, adopts natural traditional Chinese medicine materials, follows prescription medication principle of the traditional Chinese medicine, is simple and convenient to prepare, wide in medicine source and low in cost, and has effects of degrading cigarette toxin, improving body immunity, achieving antisepsis and anti-inflammation, relieving cough and reducing sputum, protecting lungs and nourishing kidneys, and the like; moreover, the health care product can increase the immunity of a human body, protect cell membrane structures and functions of bronchi and lung tissues, improve tissue respiration and body metabolism, and reduce metabolic activity of cancerogenic substances. Besides, the health care product disclosed by the invention is remarkable in curative effect, reliable in action, gentle in drug property, free from toxic and side effect, and verified to have an effective rate of 98% according to clinical application, and is a very ideal clinical drug for relieving diseases caused by smoking.

The invention relates to a preparation method of an oyster mushroom mother strain culture medium and the oyster mushroom mother strain culture medium and belongs to the technical field of culture medium preparation. According to the oyster mushroom mother strain culture medium prepared by the method, based on a common PDA culture medium, cooked filtered juice of cottonseed hulls and corncobs is added, a cellulose natural culture suitable for mycelial growth of oyster mushrooms is added, the content of potatoes, glucose and agar powder in raw materials are reduced, and metabolic action of mycelia of the oyster mushroom is favorably reduced, so that the variation speed of the oyster mushroom mother strain is reduced, and degeneration of excellent characteristics of the oyster mushrooms is prevented. By using the oyster mushroom mother strain grafted by the culture medium, the growth speed and growing vigor of the mycelia of the oyster mushrooms are obviously superior to those of the mycelia of the oyster mushrooms cultured by means of a conventional PDA culture medium.