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110results about How to "Reduced metabolic activity" patented technology
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Compositions for treating biofilm
InactiveUS20020037260A1Improve the immunityReduced metabolic activityCosmetic preparationsBiocideBiofilmMicrobiology
Owner:BUDNY JOHN A +1
Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation
InactiveUS20070082393A1Improve adhesionReduced metabolic activityBioreactor/fermenter combinationsBiological substance pretreatmentsCell adhesionPolymer chemistry
The invention provides cell-adherent polymeric coatings for articles having a nanofibrillar structure. The coatings include a synthetic, non-biodegradable polymer having at least one pendent amine group, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long term culturing of cells using the polymer coated nanofibrillar structures. The polymer coated nanofibrillar structures of the invention have been found to be particularly useful for the growth and differentiation of cells, including neural precursors.
Owner:LODHI MUHAMMAD +4
Preparation method of co-crosslinked double-network hydrogel support for promoting cartilage injury repair
ActiveCN107281550AImprove adhesionThe effect of promoting defect healingTissue regenerationProsthesisCartilage injuryDouble network
The invention belongs to the field of biomedical materials and particularly relates to a preparation method of a co-crosslinked double-network hydrogel support for promoting cartilage repair and growth. The method comprises the following steps of (1) preparation of GelMA; (2) preparation of a photo-crosslinked polypeptide; and (3) preparation of a hydrogel support, namely preparing the hydrogel support from the GelMA and the photo-crosslinked HSNGLPL under the action of a photoinitiator. The prepared hydrogel support has an obvious effect of promoting new cartilage generation and cartilage defect healing, and is capable of regulating cartilage matrix secretion of normal chondrocytes around the injured tissue, mesenchymal stem cell migration to the injured part and cartilage differentiation; by virtue of a porous structure of the hydrogel support, the HSNGLPL can be crosslinked to the surface of a porous support, endogenous TFG-beta is effectively adsorbed, the concentration of local TFG-beta beta1 is improved and the effects of the biological support in the orthopedics fields, such as a cartilage defect and a cartilage injury are achieved.
Owner:SUZHOU UNIV
Method for improving recovery ratio of indigenous microbial enhanced oil recovery
InactiveCN105201474AOil displacement effect is goodImprove field test resultsFluid removalMicrobial enhanced oil recoveryCommunity structure
The invention discloses a method for improving the recovery ratio of indigenous microbial enhanced oil recovery. The method comprises the following steps: acquiring a fluid sample on a target reservoir site; analyzing an indigenous microbial community structure; determining an indigenous activator and the injection quantity thereof; selecting an on-site injection process of the indigenous activator; evaluating a physical analog enhanced oil recovery; performing on-site tests, and tracking and analyzing of on-site test effects. The method is reasonable, simple in process, easy to operate, safe and reliable, beneficial to on-site popularization and application, and low in investment and cost, greatly improves the on-site test effect, improves the recovery ratio of more than 12% during indigenous microbial enhanced oil recovery on-site tests, and thus can be widely applied to on-site tests for improving the recovery ratio of indigenous microbial enhanced oil recovery.
Owner:CHINA PETROLEUM & CHEM CORP +1
Popping boba, beverage containing same and preparation method of popping boba
ActiveCN105325829AAvoid the disadvantages of aesthetic fatigueAdd funSugar food ingredientsFood coatingProtective AgentsGenus Lactobacillus
The invention provides a popping boba, a beverage containing the same and a preparation method of the popping boba. The popping boba comprises a popping boba shell and popping boba inner juice wrapped in the shell; the popping boba shell is made of sodium alginate, the popping boba inner juice comprises an active probiotics matrix and sweet water protection fluid with a mass ratio of (1:1)-(1:9); the mass ratio of the sodium alginate to the sweet water protection fluid is (0.05:99.95)-(2:98). According to the popping boba, activated lactobacillus is buried in the soft shell formed by the sodium alginate, and is quickly burst out when being chewed, and the interestingness of a product is increased; the preservation time of the popping boba is long, and the stability of the product is good; according to the preparation method of the active probiotics popping boba, by optimizing the additive amount of a protective agent in the sweet water protection fluid, the product is enabled to have better activity of the probiotics in the shell life, and the probiotic effect of the product is added.
Owner:BRIGHT DAIRY & FOOD CO LTD
Nitrification inhibitor compositions and methods for preparing the same
InactiveUS20170362139A1Lower Level RequirementsEasy to transformBiocideAgriculture gas emission reductionNitrification inhibitorsChemistry
The present disclosure relates to enhanced nitrification inhibitor dry fertilizer compositions, methods for making the same, and their use in agricultural applications.
Owner:DOW AGROSCIENCES LLC
Tobacco special-purpose charcoal-based compound fertilizer, and preparation method and application method thereof
InactiveCN109879693AReduce environmental pollutionEasy to drawBio-organic fraction processingFertilising methodsChemistryNitrogen fertilizer
The invention belongs to the technical field of fertilizer, and more specifically relates to a tobacco special-purpose charcoal-based compound fertilizer, and a preparation method and an application method thereof. The tobacco special-purpose charcoal-based compound fertilizer comprises, by weight, tobacco straw, waste tobacco, pig manure, earthworm manure, vegetable waste, domestic garbage, nitrogen fertilizer, phosphate fertilizer, potassium fertilizer, trace element liquid fertilizer, a compound microbial agent, and an adhesive, and is prepared through a plurality of technologies. The tobacco special-purpose charcoal-based compound fertilizer is high in granulation rate, is capable of obviously improving fertilizer utilization rate, and is capable of improving soil acidifying and hardening after being applied to tobacco field, and increasing soil available nutrient content; the quality of the harvested tobacco leaves is improved obviously, the proportion of middle and upper-grade tobacco leaves is increased, the yield per mu and the output value per mu are obviously increased; and the tobacco special-purpose charcoal-based compound fertilizer is taken as a base fertilizer, onlyone time of application is capable of satisfying all the requirements of tobacco on nutrients in the tobacco growth period, reducing the using amount and the application frequency of traditional fertilizers; using is convenient; and labor is saved.
Owner:GUIZHOU TOBACCO CORP QIANXINAN CORP
Processes for bioconversion of syngas to oxygenated organic compound providing storage and reactivation of microorganism concentrates
InactiveUS20140051139A1Relieve pressureReduce riskBiofuelsMicroorganism preservationSyngasMicroorganism
Processes are disclosed for preparing microorganism concentrates from fermentation broth containing a free suspension of the microorganisms which is used for the anaerobic conversion of syngas to oxygenated organic compound. The processes involve the use of processing steps and the presence of certain additives to enhance the ability of the microorganism concentrate to be stored for extended periods and reactivated.
Owner:SYNATA BIO INC
Methods and compositions for treating tumor diseases
InactiveUS20100166747A1Reduced metabolic activitySymptoms improvedOrganic active ingredientsPeptide/protein ingredientsDiseaseNucleotide
The present invention provides, in part, methods for treating a tumor in a human subject comprising inhibiting IGF-1 receptor signaling, methods of determining whether a tumor is more or less likely to respond to such treatment, and compositions for practicing such methods. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.
Owner:AMGEN INC
Engineering of metabolic control
InactiveUS7122341B1Reduced metabolic activityHighly refinedBacteriaSugar derivativesHeterologousMetabolite
The invention features a method of producing heterologous molecules in cells under the regulatory control of a metabolite and metabolic flux. The method can enhance the synthesis of heterologous polypeptides and metabolites.
Owner:FOOD IND RES & DEV INST
Nitrification inhibitor compositions and methods for preparing the same
InactiveUS20180049438A1Lower Level RequirementsEasy to transformBiocideAgriculture gas emission reductionNitrification inhibitorsChemistry
The present disclosure relates the enhanced nitrification inhibitor compositions, methods for making the same, and their use in agricultural applications.
Owner:CORTEVA AGRISCIENCE LLC
Fresh-keeping liquid for fresh cut fruits and vegetables
InactiveCN110269093AGrowth inhibitionLow toxicityFood ingredient as antioxidantFruit and vegetables preservationSolubilitySpoilage bacteria
The invention discloses a fresh-keeping liquid for fresh cut fruits and vegetables. The fresh-keeping liquid is prepared by compounding lactobacillus plantarum, carbon dots, ascorbic acid, citric acid, disodium ethylene diamine tetraacetate, glycerol and calcium propionate. According to the fresh-keeping liquid, the lactobacillus plantarum and the carbon dots are combined for fresh keeping of the fresh cut fruits and vegetables for the first time, the capability of lactic acid bacteria to inhibit the growth of spoilage bacteria and pathogenic bacteria is fully exerted, abundant radicals on the surfaces of the carbon dots are utilized, the water solubility, the reducibility and the antibacterial activity are good, the permeation effect on plant cells is enhanced, and the technical effects of synergistic bacteriostasis, sterilization and enzyme activity inhibition are achieved. All raw materials involved in a formula of the fresh-keeping liquid are of the food grade, the fresh cut fruits and vegetables can be directly eaten after being soaked in the fresh-keeping liquid, and the taste of the fresh cut fruits and vegetables cannot be adversely influenced. A preparation process is simple, the fresh-keeping effect is excellent, and the shelf life of the fresh cut fruits and vegetables can be prolonged to 12-15 days after the fruits and the vegetables are soaked in the fresh-keeping liquid and stored at the low temperature.
Owner:AGRO PROD PROCESSING RES INST YAAS
Transport case for aquatic products
InactiveCN107079866AReduced metabolic activityImprove survival ratePisciculture and aquariaTruckMagnet
The invention discloses a transport case for aquatic products. The transport case comprises a cover, a metal trunk and an ice block box. On the cover of the transport case, ice blocks can be arranged in the ice block box, so that the temperature in the case can be reduced, the aquatic products can conveniently survive at a relatively low temperature, the metabolic activities of the aquatic products are reduced, and long-term survival of the aquatic products is promoted. A magnet is arranged at the bottom of the case, so that the trunk at the bottom of a truck is attracted by the magnet, the condition that the cases are moved in the vehicle so as to be collided with one another due to sudden acceleration or sudden brake of the vehicle is avoided, and the survival rate of the aquatic products is guaranteed. Due to springs and sponges in the cases, vibration and impact of outside on the cases can be buffered, and the survival rate of the aquatic products in the transport process is improved. An inner cylinder is arranged in the case, and when a user needs to change water or needs to totally take the aquatic products in the case out, the inner cylinder can be directly taken out of the inner case, and the water flows out through a net at the bottom of the inner cylinder, so that the labor force is reduced.
Owner:长沙健金电子技术有限公司
CYP2D6 gene segment containing 4094C>A mutant, protein segment coded by same and application thereof
ActiveCN103436545AReduced metabolic activityMicrobiological testing/measurementOxidoreductasesAlleleMutant
The invention belongs to the field of biology and relates to a single base mutant at the 4094th site of CYP2D6 allele, wherein C at the site is mutated into A. The invention particularly relates to a nucleic acid segment containing the mutant site and a corresponding protein segment coded by the nucleic acid segment, a reagent and detection method for identifying the mutant site, application of the site, and especially application of identification of the site in medicine instruction.
Owner:蔡剑平
Method for prolonging fresh keeping time of vegetables by combination of ultrasonic wave composite ozone water and controlled atmosphere
The invention discloses a method for prolonging fresh keeping time of vegetables by combination of ultrasonic wave composite ozone water and controlled atmosphere, and belongs to the technical field of storing and fresh keeping of agriculture products. The method comprises the following steps of selectively picking fresh vegetables, performing sorting, performing fresh keeping through combinationof ultrasonic wave composite ozone water and controlled atmosphere, and during the storage mid period, performing treatment with ozone gas treatment to perform coprocessing on the vegetables for freshkeeping, so as to prolong the storage period. According to the method, quality and nutrient components of the vegetables during the storage period can be well maintained, the storage period of the vegetables can be prolonged to 60 days, and the method is suitable for oversea sail, so that the inconvenience and the cost of side dish during halfway for oversea ships can be greatly saved.
Owner:WUXI HAIHE EQUIP TECH CO LTD +1
Lactobacillus delbrueckii subsp. bulgaricus strain with low beta-galactase activity and application thereof
InactiveCN104694418AStable after acidificationPost-acidification slowdownMilk preparationBacteriaMicroorganismMicrobiology
The invention relates to lactobacillus bulgaricus with low beta-galactase activity and application thereof. The lactobacillus bulgaricus is classified and named as lactobacillus delbrueckii subsp. bulgaricus, and the microbial preservation number is CGMCC No.9957. The strain is screened from the lactobacillus bulgaricus separated from a traditional milk product and has relatively stable performance, the instability, caused by overmuch passage number, similar to mutant strains is avoided, and furthermore, weak post-acidification capacity can be preserved all the time, so that the post-acidification of yoghourt in a preservation period can be effectively delayed in the actual application, and the shelf life of the yoghourt can be prolonged; furthermore, the strain has an excellent fermentation property and can be used as a weak post-acidification yoghourt fermentation agent to be applied to industrialization.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
Transplants
InactiveUS20130143833A1Increase storage spaceReduce vasospasmBiocideSurgical drugsPotassium channel openerAgonist
The present invention relates to a method of reducing injury to cells, a tissue or organ to be explanted from a body and upon implantation into a body by administering a composition to the cell, tissue or organ, including: (i) a potassium channel opener or agonist and / or an adenosine receptor agonist; and (ii) an antiarrhythmic agent. The invention also provides a composition for reducing injury to vasculature ex vivo including: (i) a potassium channel opener or agonist and / or an adenosine receptor agonist; and (ii) an antiarrhythmic agent.
Owner:HIBERNATION THERAPEUTICS A KF
Konjac glucomannan antibacterial preservative film
ActiveCN103319735BReduce decompositionImprove stabilityFruit and vegetables preservationPreservativeTitanium oxide
Owner:陕西开吉艾沐生物科技有限公司
CYP2D6 gene segment containing 2519A>C mutation, coded protein fragment thereby and applications thereof
ActiveCN103614390AReduced metabolic activityMicrobiological testing/measurementOxidoreductasesAlleleProtein Fragment
The invention belongs to the biological field, and relates to single base mutation of the 2519th locus of CYP2D6 allele. The locus is mutated into C from A. The invention concretely relates to a nucleic acid segment containing the mutation locus, a corresponding coded protein fragment, agents for identification of the mutation locus, a detection method and applications of the locus, especially applications of the identification of the locus in medication guidance.
Owner:蔡剑平
Method for large-scale high-density suspension culture of cell 293-high yielding adenovirus
ActiveCN110894494AAchieve high density cultureReduce culture lossCulture processMicroorganism based processesSerum freeCultured cell
The invention discloses a method for large-scale high-density suspension culture of a cell 293-high yielding adenovirus. The method comprises the steps of firstly, carrying out serum-free 293SFM culture, then, starting CD culture medium culture to produce a virus, combining a perfusion technology and a cutoff technology, and meanwhile, controlling temperature changes of cell culture and viral infection. According to the method, the enlarging of cell culture density is achieved, the volume of cell culture is reduced, subsequent labor intensity is lowered, the yield of the virus is increased, the cost is reduced, the cell death loss of a cutoff process is reduced, the quality is uniform and stable during culture, a production process is close in link and easy in control, and thus, stable quality of batches is guaranteed.
Owner:GUANGXI WUZHOU PHARMA GRP
Combination and use of drugs
InactiveUS20060276549A1Reduced metabolic activityReduce energy consumptionOrganic active ingredientsBiocideDiseasePharmaceutical drug
The present invention is directed to preferred pharmaceutical compositions comprising sibutramine and rimonabant and use of sibutramine and rimonabant to treat obesity and obesity related disorders in a patient.
Owner:ABBOTT LAB INC
CYP2D6 gene segment containing 1735G>C mutation, coded protein fragment thereby and applications thereof
ActiveCN103614388AReduced metabolic activityMicrobiological testing/measurementOxidoreductasesAlleleProtein Fragment
The invention belongs to the biological field, and relates to single base mutation of the 1735th locus of CYP2D6 allele. The locus is mutated into C from G. The invention concretely relates to a nucleic acid segment containing the mutation locus, a corresponding coded protein fragment, agents for identification of the mutation locus, a detection method and applications of the locus, especially applications of the identification of the locus in medication guidance.
Owner:蔡剑平
Improved cell culture device
PendingUS20200318048A1Less accessibleIncrease the number ofBioreactor/fermenter combinationsBiological substance pretreatmentsBiotechnologyBiomedical engineering
There is described a method of reducing or preventing the agglomeration of spheroids comprising the use of a cell culture device comprising: a cell culture chamber comprising a base and side walls extending from the base to enclose a volume of the cell culture chamber; an inlet in the base or side walls of the cell culture chamber adapted for fluid communication into the chamber; and an outlet in the base or side walls of the cell culture chamber adapted for fluid communication out of the chamber; wherein the base of the cell culture chamber comprises a discontinuous surface adapted to reduce or prevent the agglomeration of spheroids.
Owner:PHILIP MORRIS PROD SA
Method for corn seed priming
InactiveCN111165114AIncrease vitalityIncrease resistanceBiocidePlant growth regulatorsSeed primingAqueous solution
The invention discloses a method for corn seed priming. The method comprises the following steps: selecting corn seeds and treating the seeds with disinfection, cleaning and drying; dissolving polyamine in water to obtain a polyamine aqueous solution, and making a treating fluid after mixing; adding the treating fluid to the corn seeds and conducting low-temperature priming; and cleaning and re-drying the corn seeds which are already primed, and conducting sowing or low-temperature storage. The method is easy to operate and master and short in duration, and can promote germination and growth of seedlings and enhance cold resistance in case of low temperatures after corn sowing.
Owner:LIAONING ACAD OF AGRI SCI
CYP2D6 gene segment containing 3334G>A mutant, protein segment coded by same and application thereof
InactiveCN103436543AReduced metabolic activityMicrobiological testing/measurementOxidoreductasesAlleleProtein Fragment
The invention belongs to the field of biology and relates to a single base mutant at the 3334th site of CYP2D6 allele, wherein G at the site is mutated into A. The invention particularly relates to a nucleic acid segment containing the mutant site and a corresponding protein segment coded by the nucleic acid segment, a reagent and detection method for identifying the mutant site, application of the site, and especially application of identification of the site in medicine instruction.
Owner:蔡剑平
Microencapsulated nitrification inhibitor compositions
ActiveUS20170369386A1Prevent and reduce crystal formation issuePrevent and inhibit crystal formationBiocideNitrogenous fertilisersNitrification inhibitorsChemistry
The present disclosure relates to an improved nitrification inhibitor composition and its use in agricultural applications.
Owner:CORTEVA AGRISCIENCE LLC
CYP2C9 gene segment comprising 293G>T, coded protein segment and application thereof
ActiveCN103045619AReduced metabolic activityMicrobiological testing/measurementOxidoreductasesAllele-specific oligonucleotideWild type
The invention belongs to the field of biology, and relates to single base mutation. More particularly, the invention relates to a mutation site of a 293th site of SEQ ID NO.2 corresponding to a CYP2C9 gene, wherein the mutation site is mutated into T from wild type G. The invention also relates to a nucleic acid segment, a coded protein segment and application thereof. The invention also provides an allele-specific oligonucleotide, kit and method for detecting the mutation site.
Owner:蔡剑平
Method for producing medium-chain fatty acid from fermented liquor of livestock and poultry manure
ActiveCN110643644BReduced metabolic activityReduce MethanationFermentationBiotechnologyLivestock manure
Owner:INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
Health care product used by smokers
ActiveCN103610061AImprove immunityImprove the immunityDigestive systemRespiratory disorderMedicinal herbsTracheitis
The invention discloses a health care product used for smokers. The health care product used for smokers consists of agilawood, sandalwood, citron and root of kudzu vine. The materials are cleaned to remove impurities, dried, crushed into 80-150 meshes, and decocted for 2 hours-3 hours by adding water 8-10 times the amount of the total materials, and decoction is collected to obtain the health care product. The health care product used for smokers is used for treating halitosis, bitter taste, pharyngitis, parageusia, cough with excessive phlegm, and trachitis caused by smoking, adopts natural traditional Chinese medicine materials, follows prescription medication principle of the traditional Chinese medicine, is simple and convenient to prepare, wide in medicine source and low in cost, and has effects of degrading cigarette toxin, improving body immunity, achieving antisepsis and anti-inflammation, relieving cough and reducing sputum, protecting lungs and nourishing kidneys, and the like; moreover, the health care product can increase the immunity of a human body, protect cell membrane structures and functions of bronchi and lung tissues, improve tissue respiration and body metabolism, and reduce metabolic activity of cancerogenic substances. Besides, the health care product disclosed by the invention is remarkable in curative effect, reliable in action, gentle in drug property, free from toxic and side effect, and verified to have an effective rate of 98% according to clinical application, and is a very ideal clinical drug for relieving diseases caused by smoking.
Owner:马军保
Preparation method of oyster mushroom mother strain culture medium and oyster mushroom mother strain culture medium
ActiveCN107142212AMaintain the characteristics of the strainImprove the ability to break down celluloseFungiMicroorganism based processesCelluloseOyster
The invention relates to a preparation method of an oyster mushroom mother strain culture medium and the oyster mushroom mother strain culture medium and belongs to the technical field of culture medium preparation. According to the oyster mushroom mother strain culture medium prepared by the method, based on a common PDA culture medium, cooked filtered juice of cottonseed hulls and corncobs is added, a cellulose natural culture suitable for mycelial growth of oyster mushrooms is added, the content of potatoes, glucose and agar powder in raw materials are reduced, and metabolic action of mycelia of the oyster mushroom is favorably reduced, so that the variation speed of the oyster mushroom mother strain is reduced, and degeneration of excellent characteristics of the oyster mushrooms is prevented. By using the oyster mushroom mother strain grafted by the culture medium, the growth speed and growing vigor of the mycelia of the oyster mushrooms are obviously superior to those of the mycelia of the oyster mushrooms cultured by means of a conventional PDA culture medium.
Owner:ZHUMADIAN ACADEMY OF AGRI SCI
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