The invention relates to a plaster for treating neck, shoulder, waist and leg diseases. The plaster is prepared from raw medicaments such as sesame oil, red lead, angelica, cinnamon, eucommia bark, almond, cassia twig, mulberry twig, tall gastrodia tuber, frankincense, divaricate saposhnikovia root, processed nux vomica, rhubarb, garden balsam stem, pepper, raw kusnezoff monkshood root, musk, Szechuan lovage rhizome, pangolin, Chinese honeylocust spine, myrrh, crude Sichuan aconite root, garter snake, fructus cnidii, glandularstalk St.Paulswort herb, root of red-rooted salvia, clematis root, cortex acanthopanacis, common clubmoss herb, centipede, scorpion, borneol, dragon's blood, asarum, earthworm, pawpaw, logwood, mint, Chinese holly leaf, Mongolian snake gourd root, licorice, rehmannia root, polygonum multiflorum, wolfberry, gentiana macrophylla, pseudo-ginseng and the like. The selected raw materials are reasonable in compatibility, supplement the effects and can achieve a good synergistic effect; and the plaster for treating neck, shoulder, waist and leg diseases can treat both symptoms and root causes, avoids relapse after healing and consolidates the curative effect, and the total effective rate can reach over 95%.