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Benzalkonium bromide/sodium chloride flushing fluid and preparation method thereof

A technology of ammonium bromide sodium chloride and benzalkonium bromide, which is applied in the field of benzalkonium bromide sodium chloride rinse solution and its preparation, can solve the impact of benzalkonium bromide on the sterilization ability, and has not yet seen the preparation of benzalkonium bromide chloride Sodium chloride flushing solution and other problems, to achieve the effect of good safety, broad clinical application prospects, and strong antibacterial effect

Inactive Publication Date: 2017-06-20
CHENGDU ZHENGKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, whether the addition of sodium chloride will affect the sterilizing ability of benzalkonium bromide is also unknown to technicians
[0004] So far, there is no relevant report on the preparation of benzalkonium bromide sodium chloride flushing solution

Method used

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  • Benzalkonium bromide/sodium chloride flushing fluid and preparation method thereof
  • Benzalkonium bromide/sodium chloride flushing fluid and preparation method thereof
  • Benzalkonium bromide/sodium chloride flushing fluid and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] Embodiment 1 The preparation of benzalkonium bromide sodium chloride rinse solution of the present invention

[0024] 1. Product formula

[0025]

[0026] 2. Production prescription

[0027] Benzalkonium Bromide 150g Sodium chloride 27.0kg Water for Injection Add to 3000L

[0028] 3. Process route

[0029] (1) Preparation: Take by weighing the prescribed amount of benzalkonium bromide and sodium chloride, add them into the liquid preparation tank with an appropriate amount of water for injection, and under stirring, continue to dilute to 3000L with water for injection to completely dissolve it.

[0030] (2) Fine filtration: filter with a microporous membrane with a diameter of 0.22um.

[0031] (3) Intermediate detection: including properties, benzalkonium bromide content and pH value. The pH value is 4.5-6.5.

[0032] (4) Filling: 3000ml or 2000ml per bag under 60°C.

[0033] (5) Sealing: welding cover.

[0034] (6) Sterilization: ...

experiment example 1

[0038] Experimental Example 1 Quality Evaluation of Benzalkonium Bromide Sodium Chloride Rinsing Solution of the present invention

[0039] 1. Traits

[0040] The product prepared according to Example 1 was visually inspected under natural light, and it was a colorless clear liquid.

[0041] 2. pH value

[0042] According to the "Pharmacopoeia of the People's Republic of China" appendix "pH value determination method" test, the pH value is 4.0 ~ 7.0.

[0043] 3. Osmolarity

[0044] Take this product, according to the "Pharmacopoeia of the People's Republic of China" appendix "osmotic pressure molar concentration inspection method" test, it is 260 ~ 320mOsmol / kg.

[0045] 4. Capacity

[0046] Take this product and test according to the "Minimum Filling Quantity Inspection Method" in the appendix of "Pharmacopoeia of the People's Republic of China".

[0047] 5. Content of benzalkonium bromide

[0048] Determination according to the appendix "High Performance Liquid Chromat...

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PUM

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Abstract

The invention discloses a benzalkonium bromide / sodium chloride flushing fluid. Every 1000L of flushing fluid is composed of the following components: 40-60g of benzalkonium bromide, 8.55-9.45kg of sodium chloride and the balance of water. Quality evaluation results prove that the flushing fluid has strong bacteriostatic action on Escherichia coli and Staphylococcus aureus, has no obvious irritation to the skin and eyes and is favorable in stability, thereby having wide clinical application prospects.

Description

technical field [0001] The invention relates to a benzalkonium bromide sodium chloride rinse solution and a preparation method thereof, belonging to the field of disinfection products. Background technique [0002] Benzalkonium bromide is a cationic surfactant broad-spectrum fungicide, and is one of the most commonly used fungicides at present. It can change the permeability of the bacterial cytoplasmic membrane, make the bacterial cytoplasmic substances extravasate, hinder its metabolism and play a killing role, and has a significant inhibitory effect on Gram-positive bacteria. Clinically, it is mostly used for skin disinfection before surgery, mucous membrane and wound disinfection, and surgical instrument disinfection. However, benzalkonium bromide has obvious irritation to the body, and it has been reported to cause allergic conjunctivitis, vision loss, contact dermatitis, as a vaginal douche and even cause death, which limits its wide clinical application application....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/18A61K33/14A61K9/08A61P31/04A61P31/02A61P17/00A61P17/02A01N59/08A01N33/12A01P1/00A61K31/14A61L101/32A61L101/06
CPCA01N33/12A01N59/08A61K9/0014A61K9/08A61K31/14A61K33/14A61L2/18A61L2202/24A01N2300/00A61K2300/00Y02A50/30
Inventor 朱贞华任秀如苏丹丹李静白跃芳袁婷丁侃
Owner CHENGDU ZHENGKANG PHARMA
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