Oral spray used for cancer patients

A technology for oral spray and tumor patients, applied in the field of oral care, can solve problems such as poor safety performance, achieve high safety, avoid severe oral mucositis, and accelerate wound healing

Inactive Publication Date: 2017-05-17
JIANGSU SOLOMON BROTHER MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this spray has the effect of stimulating oral mucosal proliferation and can be used to treat oral ulcers caused by radiotherapy and chemotherapy, the raw materials contained in it, such as octopus and mountain bean root, are mostly traditional Chinese medicine components, bitter and cold, with obvious irritation and side effects , poor safety performance

Method used

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  • Oral spray used for cancer patients
  • Oral spray used for cancer patients

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Experimental program
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specific Embodiment

[0026] The raw material formulations of the mouth spray for tumor patients of Examples 1-8 are shown in Table 1.

[0027] The raw material formula situation (unit is kilogram) of table 1 embodiment 1-8.

[0028]

[0029]

[0030] In each embodiment, the total weight of raw materials is 100 kg, wherein the amount of deionized water added is determined by subtracting the weight of other raw materials from 100 kg.

[0031] Specifically, in the oral spray of the present invention, sodium bicarbonate and sodium citrate are acidity regulators to adjust the pH of the oral spray, thereby regulating the acidic environment in the oral cavity of tumor patients, avoiding damage to the oral mucosa, and greatly reducing the risk of disease. The production of bacteria helps to repair the oral mucosa. In addition, sodium citrate can also be used as a preservative, which can prolong the preservation time of oral spray.

[0032] Forsythia fruit extract is obtained from extracting forsyt...

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Abstract

The invention relates to an oral spray used for cancer patients, and relates to the technical field of oral care. The oral spray is prepared from the following components in percentage by weight: 2% to 15% of a sugar alcohol humectant, 2% to 16% of a forsythia fruit extract, 2% to 10% of a stevia rebaudianum extract, 2% to 10% of a propolis extract, 1% to 10% of a blueberry extract, 0.2% to 10% of a solubilizer, 0.2% to 2% of thymol crystals, 0.7% to 10% of a metal astringent, 0.5% to 5% of a preservative, 0.05% to 4% of guaiazulene sodium sulfonate, 0.1% to 2.5% of poloxamer, 0.7% to 9% of an acidity regulator and the balance of deionized water. The oral spray disclosed by the invention is safe, and free of obvious stimulation or side effect, has the effects of relieving pain, inhibiting bacteria, resisting viruses and eliminating free radicals, and is capable of relieving oral inflammatory reactions caused by chemoradiotherapy, relieving pains caused by oral mucosa damage and promoting oral mucosa repair.

Description

technical field [0001] The invention relates to an oral spray for tumor patients and relates to the technical field of oral care. Background technique [0002] Xerostomia and oral mucositis can be caused in varying degrees during radiotherapy and chemotherapy in cancer patients. While chemotherapy drugs inhibit or kill tumor cells, they can also have obvious toxic effects on the oral mucosal tissues that are renewing faster, and oxygen free radicals are generated accordingly, thus causing a series of symptoms of oral mucositis, such as, first, oral mucosal atrophy , thinning, increased fragility, followed by inflammatory reactions, pain and ulcers. For some head and neck radiotherapy patients, salivary glands and submandibular glands are often within the range of irradiation. After radiation irradiation, in addition to the decrease in saliva secretion, it will also cause changes in its properties, making saliva viscous and pH lower, thereby destroying the saliva. The lubri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/12A61K47/02A61K47/12A61P1/02A61P35/00A61K31/05A61K31/185A61K33/30A61K33/06A61K35/644
CPCA61K9/006A61K9/12A61K31/05A61K31/185A61K33/06A61K33/30A61K35/644A61K36/287A61K36/45A61K36/634A61K47/02A61K47/12A61K2300/00
Inventor 贾宁张晓晴
Owner JIANGSU SOLOMON BROTHER MEDICAL TECH CO LTD
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