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Tinizadole dental plaster for treating buccal inflammation

An oral patch, tinidazole technology, applied in the directions of sheet delivery, medical preparations containing active ingredients, digestive system, etc., to achieve the effect of maintaining drug efficacy, reducing drug side effects, and reducing the degree of adverse reactions

Inactive Publication Date: 2006-04-26
BEIJING ZICHENXUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it is far from meeting the clinical needs. Many hospitals have made tinidazole and metronidazole oral film, stick and gargle, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Grind the menthol into powder, sieve and set aside, and sieve the hydroxypropyl methylcellulose, protein sugar and lactose separately, set aside. Get 5g tinidazole, 13g hydroxypropyl methylcellulose, 0.5g carbomer, 2g protein sugar, 2g lactose, 0.03g menthol, 0.23g magnesium stearate and mix evenly, then press into tablets according to conventional methods, Each tablet contains 5mg of tinidazole.

Embodiment 2

[0023] Grind the menthol into powder and sieve it for later use; sieve the hydroxyethyl cellulose, protein sugar and lactose respectively for later use. Get 200g tinidazole, 440g hydroxyethyl cellulose, 213g carbomer 943, 123g protein sugar, 123g lactose, 1g menthol, 10g magnesium stearate and mix uniformly, then press into tablets according to the method of embodiment 1, wherein Each tablet contains 5 mg of tinidazole.

Embodiment 3

[0025] According to the State Food and Drug Administration New Drug Clinical Research Approval No. 2002HL0330, the concentration of tinidazole oral patch in the saliva of 10 healthy volunteers was determined by high performance liquid chromatography. Tests have shown that the tinidazole oral patch of Example 1 has a sticking time of 1.5-2.5 hours on the tooth surface, and the effective bacteriostatic concentration (greater than 0.12 μg / ml) in saliva can be maintained for 4 hours. The sticking time of the tinidazole oral patch of Example 2 on the tooth surface is 2-3 hours, and the effective bacteriostatic concentration (greater than 0.12 μg / ml) in saliva can be maintained for 5 hours. It shows that the adhesion and sustained release effect of the tinidazole oral patch of the present invention are obvious, and compared with the traditional regular release oral dosage form, it is very beneficial to exert the effect of inhibiting oral anaerobic bacteria.

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PUM

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Abstract

The invention relates to a novel dosage type of tinidazole for local and slow release administration, wherein tinidazole is used as the main pharmaceutical active composition, and biological viscous polymers are used as the pharmaceutical carriers.

Description

technical field [0001] The invention relates to an oral patch for treating oral inflammation made from tinidazole as a main raw material. Specifically, the present invention relates to a new dosage form of tinidazole with tinidazole as the main pharmaceutical active ingredient and bio-adhesive polymer as the drug carrier for topical and sustained release administration. Background technique [0002] Periodontal diseases such as gingivitis and periodontitis are common and frequently-occurring diseases in the department of stomatology, and the incidence rate of this disease in my country is about as high as 70%. Inflammation of gingival tissue can lead to gingival congestion, edema, pus, bleeding and bad breath. Destruction of periodontal supporting tissue can cause tooth loosening and displacement, and eventually gingival shedding, which not only reduces chewing ability, affects digestive function, but also hinders appearance. Further damage to the periodontal tissue can aff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164A61K9/70A61P1/02
Inventor 马跃陈贵品
Owner BEIJING ZICHENXUAN PHARMA
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