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Drop for treating otitis externa mycotica and preparation method thereof

An otitis externa and fungal technology, applied in the field of compound ear drops, can solve the problems of unreachable, high cost, and difficult to guarantee therapeutic effect.

Inactive Publication Date: 2010-07-07
周宣岩 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some patients with narrow external auditory canal can not reach the depth of the ear canal at all, and the treatment effect is often difficult to guarantee.
However, oral and injection antifungal drugs have large toxicity and adverse reactions, and the cost is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: Take 3g of fluconazole and 3g of menthol, dissolve them with 30ml of ethanol; weigh 5g of tinidazole, put them into a container, add about 100ml of distilled water, put them in a water bath at 60°C to dissolve them, and then add to In the fluconazole and menthol solution, ultrasonically oscillate for 5 minutes, then add 100g of glycerin, and ultrasonically oscillate until the dispersion is uniform, free of bubbles and solid matter, adjust the pH value to 5.5~6.5 with 10ml of 1mol / L sodium hydroxide solution, add Distilled water to 1000mL, filtered, steam sterilized at 100°C for 30 minutes, and dispensed into 8ml / cartridge under sterile conditions.

Embodiment 2

[0008] Example 2: Take 30g of fluconazole and 30g of menthol, dissolve them with 200ml of ethanol; weigh 50g of tinidazole, put them into a container, add about 200ml of distilled water, put them in a water bath at 60°C to dissolve them, and then add to In the fluconazole and menthol solution, ultrasonically oscillate for 5 minutes, then add 800g glycerin, and ultrasonically oscillate until the dispersion is uniform, free of air bubbles and solid matter, adjust the pH value to 5.5~6.5 with 100ml of 1mol / L sodium hydroxide solution, add Distilled water to 1000mL, filtered, steam sterilized at 100°C for 30 minutes, and dispensed into 8ml / cartridge under sterile conditions.

Embodiment 3

[0009] Example 3: Take 10g of fluconazole and 10g of menthol and dissolve them with 100ml of ethanol; take 15g of tinidazole and put it in a container, add about 100ml of distilled water, put it in a water bath at 60°C to dissolve it, and then add it to In the fluconazole and menthol solution, ultrasonically oscillate for 5 minutes, then add 200g of glycerin, and ultrasonically oscillate until the dispersion is uniform, free of bubbles and solid matter, adjust the pH value to 5.5~6.5 with 35ml of 1mol / L sodium hydroxide solution, add Distilled water to 1000mL, filtered, steam sterilized at 100°C for 30 minutes, and dispensed into 8ml / cartridge under sterile conditions.

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PUM

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Abstract

The invention relates to a compound ear drop for treating otitis externa mycotica, in particular to an ear drop for treating otitis externa mycotica. The drop is prepared by the the following ingredients: 3-30g of fluconazol, 5-50g of tinidazole, 3-30g of menthol, 100-800g of glycerine, 30-200ml of alcohol, 5-100ml of 1mol / L sodium hydroxide solution, and 1000ml of distilled water. The drop contains both antifungal drug and antianaerobic drug which enable the ear drop to have both antifungal activity and antianaerobic activity. In the process of preparation allocation, the tinidazole being slightly soluble into water need be heated by aqueous bath to be dissolved, the fluconazol and the menthol are easily dissolved into the alcohol. The alcohol is used for not only dissovling both the fluconazol and the menthol, but also being taken a transdermal accelerant of the ear drop, as well as drying the external acoustic meatus. The menthol can dispel wind to make the skin and the membrana mucosa cool and relieve the complaint and pain. A fixed amount of glycerine can protect the ear mucosa and keep the preparation tensile and adhesive.

Description

Technical field: [0001] The invention relates to a compound ear drop for treating fungal otitis externa, in particular to a compound ear drop for treating fungal otitis externa. Background technique: [0002] Mycosis of the external auditory canal is a skin infection caused by the reproduction and growth of fungi after entering the external auditory canal. Most of them are limited to the external ear, and occasionally they can invade the middle ear or the radical mastoidectomy cavity. The disease is more common in provinces with humid and hot climate in southern my country, and it has also increased significantly in northern my country in recent years. Pathogens such as Aspergillus, Penicillium and Candida are more common. Fungi are resident bacteria in the normal human body. Long-term or repeated use of antibiotics, chemotherapy and radiotherapy for malignant tumors, and application of glucocorticoids are common causes of fungal infections. Local itching and exudative inf...

Claims

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Application Information

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IPC IPC(8): A61K31/4196A61K31/4164A61K31/045A61K9/08A61P31/10A61P27/16
Inventor 周宣岩陶谦吕凌燕
Owner 周宣岩
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