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A kind of preparation method of tinidazole sodium chloride injection

A technology of nidazole sodium chloride and injection, which is applied in the field of preparation of tinidazole sodium chloride injection, and can solve problems such as poor stability and solubility

Inactive Publication Date: 2011-12-14
ANHUI GLOBAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Because the stability and solubility of tinidazole sodium chloride injection are not very good, they are currently packaged in glass bottles

Method used

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  • A kind of preparation method of tinidazole sodium chloride injection

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Embodiment

[0018]

[0019] Preparation:

[0020] 1. Add about 1 / 2 amount of water for injection into the clean concentrated compounding tank, and slowly pour 9kg of sodium chloride for injection into the concentrated compounding tank to dissolve it while the concentrated compounding tank is turned on and stirred. To prevent sinking and agglomeration, the medicinal powder adhered to the tank wall should be rinsed with water for injection, and after it is completely dissolved, add medicinal charcoal 0.05% (W / V is calculated by dilute volume), stir evenly, and steam into the interlayer to heat and boil , and keep boiling for 5 minutes, turn off the steam.

[0021] 2. After the concentrated material is filtered to remove charcoal, add the dilute compounding tank, add water for injection at the same time and turn on the dilute compounding tank to stir. inside the tank.

[0022] 3. Add an appropriate amount of water for injection into a clean plastic container, slowly add the weighed tini...

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Abstract

The invention relates to a preparation method of tinidazole sodium chloride injection, which comprises the steps of concentrated preparation, heating, filtration, dilution, adjustment of pH value, filtration, filling, sealing, sterilization, inspection and the like. The tinidazole sodium chloride injection prepared by the preparation method has good stability and can be packaged in plastic bottles.

Description

technical field [0001] The invention relates to a preparation method of tinidazole sodium chloride injection, in particular to a preparation method of tinidazole sodium chloride injection with good stability. Background technique [0002] Tinidazole is a third-generation quinolone broad-spectrum antibacterial drug. Its injection is clinically used to treat infections caused by sensitive bacteria, and its curative effect is definite. Because the stability and solubility of tinidazole and sodium chloride injection are not very good, they are all packaged in glass bottles at present. However, infusion products packaged in plastic bottles have the characteristics of light weight, convenient transportation, unbreakable bottle body, easy to ensure product quality, and easy-to-open bottle caps with easy-pull ring design, etc., which have been widely used in medical institutions at all levels in my country in recent years. It is widely used by medical workers; in addition, since the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4164A61K47/02A61P31/04A61P31/10
Inventor 李静
Owner ANHUI GLOBAL PHARM CO LTD
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