3results about How to "Effective relief" patented technology

This invention discloses the application of β-1,4-galactosyltransferase 1 and its inhibitors in liver diseases, particularly acute liver injury and liver failure. The application of β-1,4-galactosyltransferase 1 and its inhibitors in acute liver injury and liver failure provides the correlation between β-1,4-galactosyltransferase 1 and acute liver injury and liver failure, confirming that inhibiting the activity of β-1,4-galactosyltransferase 1 can alleviate acute liver injury and liver failure. β-1,4-galactosyltransferase 1 can serve as a drug target for screening acute and chronic hepatitis, liver injury, fatty liver, liver fibrosis, and acute and chronic liver failure. This invention also confirms the alleviating effect of β-1,4-galactosyltransferase 1 inhibitors on acute liver failure. β-1,4-galactosyltransferase 1 inhibitors improve acute liver failure by reducing the enzyme activity or protein expression of β-1,4-galactosyltransferase 1.

This utility model relates to the field of explosion-proof electrical technology and discloses a drainage protection structure for an explosion-proof distribution cabinet. The structure includes a base, a distribution unit body fixedly connected to the upper surface of the base, a distribution unit internally housed within the distribution unit, a drainage trough inside the distribution unit, a water collection tank fixedly connected to the lower surface of the distribution unit, a one-way drain valve fixedly connected to the lower surface of the water collection tank, a hinge fixedly connected to the outer wall of the distribution unit body, and a distribution door fixedly connected to the outer wall of the hinge. A sealing assembly is located inside the distribution door, including a sealing strip disposed inside the distribution door, and a spring fixedly connected to the inner wall of the distribution door. In this utility model, the drainage trough's design with one end higher than the other and the one-way drain valve allow for centralized drainage of condensate, preventing water accumulation. The two layers of sealing strips, spring, and push plate enhance the sealing performance.

The application discloses a compound shown in formula I, or a pharmaceutically acceptable salt, isomer, metabolite, prodrug, solvate or hydrate thereof, a pharmaceutical composition and use. The deuterated isoquinoline-amino pyrimidine compound shown in formula I provided by the application has obvious effects on blocking VISTA and PD-1 / PD-L1 signal pathways, can effectively treat and relieve diseases such as cancers, and is simple in preparation as a small molecule inhibitor and convenient for industrial production.