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Medicinal composition for treating diarrhea and preparation thereof

A composition and drug technology, applied in the field of antidiarrheal products, can solve problems such as unreachable treatment and bacterial imbalance

Inactive Publication Date: 2011-04-20
KUNMING BANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many products for the treatment of diarrhea on the market, most of which are antibiotics, which can easily lead to bacterial imbalance and produce new drug-resistant strains, failing to achieve the fundamental purpose of treatment
It is worth mentioning that many products for the treatment of diarrhea are prohibited for infants

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Racecadotril 100g

[0028] Berberine Hydrochloride 150g

[0029] Microcrystalline Cellulose 42.5g

[0030] Carboxymethyl Starch Sodium 5g

[0031] Magnesium Stearate 2.5g

[0032]

[0033] Makes 1000 pieces

[0034] Preparation method: Mix racecadotril, berberine hydrochloride, and microcrystalline cellulose evenly, granulate, granulate, add magnesium stearate, carboxymethyl starch sodium, mix evenly, compress into tablets or coat according to conventional coating operations. Film-coated, that is, tablets or film-coated tablets. It is used to treat diarrhea in children, twice a day, 1 tablet each time, and recover after 3 days of treatment.

Embodiment 2

[0036] Racecadotril 30g

[0037] Berberine Hydrochloride 150g

[0038] Starch 17.5g

[0039] Magnesium Stearate 2.5g

[0040]

[0041] Makes 1000 capsules

[0042] Preparation method: Mix racecadotril, berberine hydrochloride, starch, and magnesium stearate evenly, test the content, fill with hollow capsules, and obtain capsules. For the treatment of adult diarrhea, three times a day, 2 capsules each time, recovered after 2 days of treatment.

Embodiment 3

[0044] Racecadotril 30g

[0045] Berberine Hydrochloride 25g

[0046] Sucrose 975g

[0047] Lactose 970

[0048]

[0049] Make 1000 bags

[0050] Preparation method: Mix racecadotril, berberine hydrochloride, sucrose powder, and lactose evenly, use 40% ethanol as a wetting agent, make soft material, granulate, dry at 70±10°C, granulate, pack separately, That is, granules. For the treatment of gastroenteritis and diarrhea, three times a day, 1 bag each time, recovered after 2 days of treatment.

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PUM

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Abstract

The invention discloses a composition for treating diarrhea and a preparation thereof, relating to a medicinal composition for stopping the diarrhea. The invention also relates to a preparation of the medicinal composition for stopping the diarrhea. The medicinal composition is mainly prepared from the main raw materials of 1 part of Racecadotril and 0.25-25 parts of berberine hydrochloride as well as 0.01-250 parts of auxiliary materials in proportion. The medicinal composition has scientific and reasonable prescription, and can be used for inhibiting the rise of calcium ion concentration in colon smooth muscle cells and improving the motion functional coordination of the intestinal tract to realize the effect on stopping the diarrhea mainly by inhibiting the activity of enkephalinase and further inhibiting the excessive secretion of water and electrolyte via the Racecadotril, and simultaneously by the stronger bactericidal effect of the berberine hydrochloride on escherichia coli, Streptococcus hemolyticus, Diplococcus pneumoniae and the like.

Description

technical field [0001] The invention relates to an antidiarrheal product, in particular to a preparation capable of treating diarrhea. Background technique [0002] Racecadotril is an inhibitor of neprilysin with high specific antisecretory effect. It exerts its antidiarrheal effect by inhibiting the activity of enkephalinase, thereby inhibiting the excessive secretion of water and electrolytes. Enkephalin is a neurotransmitter in the gastrointestinal tract. The secretion of water and electrolytes, while intestinal motility is not affected. The characteristics of racecadotril are: high efficiency, rapid action, high therapeutic index, no obvious effect on the central nervous system, respiratory system, cardiovascular system, and endocrine system, does not cause constipation, and has anti-diarrhea only when excessive secretion occurs effect, but in general no such effect. [0003] Berberine hydrochloride, also known as berberine, is an alkaloid extracted or artificially sy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K31/265A61P1/12
CPCY02A50/30
Inventor 张永胜王冰刘晓凯
Owner KUNMING BANGYU PHARMA
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