Mesoporous bioactive glass/lasiosphaera composite material, preparation and applications

A technology of bioactive glass and composite materials, which is applied in the fields of hemostatic and antibacterial materials and their preparation, can solve the problems of mesoporous molecular sieves and mesoporous silicon-based xerogels with low biological activity, poor hydrophilicity, and poor hemostasis, etc., and achieve good Bioactivity and biocompatibility, low cost, infection prevention effect

Active Publication Date: 2015-09-16
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of hemostatic materials, gelatin sponge is commonly used in hospital surgical hemostatic dressings, but it has poor hydrophilicity and poor hemostasis.
The latest hemostatic product is a spray device for fibrinogen and thrombin, but before using this product, nurses are required to dissolve the fibrinogen and thrombin on the operating table, which takes more than 10 minutes, which is time-consuming and cumbersome
[0004] With the development of mesoporous materials, zeolite-containing molecular sieve rapid hemostatic sponge (trade name Quickclot) was used in the US military in Afghanistan and Iraq. The singleness and problems in the process of hemostasis, such as the exothermic burning of zeolite, the low biological activity of mesoporous molecular sieves and mesoporous silicon-based xerogels, and poor antibacterial properties have brought great inconvenience

Method used

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  • Mesoporous bioactive glass/lasiosphaera composite material, preparation and applications
  • Mesoporous bioactive glass/lasiosphaera composite material, preparation and applications
  • Mesoporous bioactive glass/lasiosphaera composite material, preparation and applications

Examples

Experimental program
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Effect test

Embodiment 1

[0047] Dissolve 10g of surfactant P123 in 500ml of deionized water, stir magnetically at 38°C until clear, adjust the pH to less than 1 with hydrochloric acid, then add 200g of tetraethyl orthosilicate (TEOS), stir until the solution is clear, Fully hydrolyze the silicon source, then magnetically stir in a water bath at 60°C for 48 hours to obtain a sol-gel white solution, leave it for 6 hours to remove the supernatant, and then dry it in an oven at 100°C for 36 hours. A dry powder was obtained. The dried powder was raised to 700°C at a heating rate of 1°C / min in a muffle furnace, and sintered for 8 hours to obtain a mesoporous bioglass powder. The particle size of mesoporous glass is 7-15um, and the pore size is 6-20nm. SEM photos show that the resulting mesoporous bioactive glass has a regular and ordered mesoporous nanopore structure, such as figure 1 shown.

Embodiment 2

[0049] Dissolve 10g of surfactant P123 in 500ml of deionized water, stir magnetically at 35~45°C until clarified, adjust the pH value to less than 1 with hydrochloric acid, and then add silicon source, phosphorus source and calcium source in sequence One or more, according to the molar ratio of silicon dioxide and other oxides (100-50): (0-50) to react and add, continue to stir and dissolve completely, then magnetically stir in a water bath at 60°C for 48 hours to obtain a sol-gel Colloidal white solution, after standing for 6 hours to remove the supernatant, dry in an oven at 100°C for 24-48 hours. A dry powder was obtained. The dried powder is raised to 550-700° C. in a sintering furnace at a heating rate of 1° C. / min, and sintered for 6 hours to obtain a mesoporous bioglass powder. The particle size of mesoporous glass is 0.3-15um, and the pore size is 2-20nm.

Embodiment 3

[0051] Dissolve 10g of surfactant P123 in 500ml of deionized water, stir magnetically at 45°C until clarification, adjust the pH value to less than 1 with hydrochloric acid, then add silicon source, phosphorus source and calcium source in sequence, according to the silica React with other oxides at a molar ratio of 1:1. After completely dissolving, heat and stir in a constant temperature water bath at 33-36°C for 48 hours to obtain a white sol liquid. Put the beaker containing the white sol solution at a constant temperature of 100°C Stand in an oven for 24 hours, and dry to obtain a dry powder. The dried powder was raised to 550° C. in a sintering furnace at a heating rate of 1° C. / min, and sintered for 4 hours to obtain a mesoporous bioglass powder. The particle size of mesoporous glass is 0.3-12um, and the pore size is 2-16nm.

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Abstract

The invention discloses a mesoporous bioactive glass/lasiosphaera composite material, preparation and applications, and belongs to the biomedical material field. The composite material is mainly composed of mesoporous bioactive glass and lasiosphaera. The preparation technology method is advantaged by simple preparation, controllable technological parameters, convenient operation and low cost. The obtained composite material has good hemostatic effects. In addition, the composite material has certain inhibition effects on staphylococcus aureus, pseudomonas aeruginosa, proteusbacillus vulgaris, diplococcus pneumonia, typhoid bacillus and escherichia coli, has inhibition effects on few pathogenic fungi, has good biological activity, and can be used as an integrated composite material of antibiosis, hemostasis and promoting tissue regeneration.

Description

technical field [0001] The invention belongs to the field of biomedical materials. Specifically relates to a hemostatic and antibacterial material and a preparation method thereof. technical background [0002] Wound bleeding is often accompanied by bacterial infection, such as clinically common bed sores, intestinal fistula, anal fistula, etc., as well as natural disasters such as earthquakes, tsunamis, skin burns, car accidents, and wars, etc., will cause bleeding, wound infection, and hard tissue injuries wait. [0003] Clinically common hemostatic materials are mostly hemostatic gauze, hemostatic bandages, etc., which often adhere to the wound during use, leading to further infection and suppuration of the wound. With the development of hemostatic materials, gelatin sponge is commonly used in hospital surgical hemostatic dressings, but it has poor hydrophilicity and poor hemostasis. The latest hemostatic product is a spray device for fibrinogen and thrombin, but befor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/46A61L15/18A61L15/42A61L27/54A61L27/56A61L27/10
Inventor 董志红
Owner CHENGDU UNIV
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