Macleaya cordata injection and preparation thereof
A technology of Boluohui and injection, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve human health risks, bacterial veterinary drug residues, and reduce animal immunity, etc. problem, to achieve the effect of inhibiting and delaying the rise of body temperature, low cost and convenient operation
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Embodiment 1
[0017] Embodiment 1: Boluohui injection according to the present invention is prepared from the following raw materials in parts by weight: 30 parts of Boluohui extract, 0.5 parts of benzyl alcohol, 40 parts of ethanol and 29.5 parts of 1,2 propylene glycol .
[0018] Its preparation method is as follows: (1) prepare the extract of Boluohui, crush Boluohui to 24 meshes, place it in a percolation device, and then add sulfuric acid with a concentration of 2% by weight equivalent to 10 times of Boluohui's weight solution, control the temperature at 80°C for diafiltration extraction, the diafiltration rate is 1 / 24 of the total volume of the sulfuric acid solution collected per hour, the leachate is collected, and the pH value of the leachate is adjusted to 7.8 by adding sodium hydroxide solution , then concentrate the percolation solution at 80°C to obtain a concentrated solution, measure the density of the concentrated solution at 80°C to be 1.10g / ml, add ethanol equivalent to 5 ...
Embodiment 2
[0019] Embodiment 2: Boluohui injection according to the present invention is prepared from the following raw materials in parts by weight: 35 parts of Boluohui extract, 10 parts of polyvinylpyrrolidone, 2 parts of procaine hydrochloride and injection 53 parts of water.
[0020] Its preparation method is as follows: (1) prepare the extract of Boluohui, crush Boluohui into a coarse powder, put it in a percolation device, and then add sulfuric acid with a concentration of 2% by weight equivalent to 12 times of Boluohui's weight solution, control the temperature at 82°C for diafiltration extraction, the diafiltration rate is 1 / 36 of the volume of the sulfuric acid solution, collect the leachate, add sodium hydroxide solution to adjust the pH value of the leachate to 8.0, and then treat the leachate at 82°C Concentrate to obtain a concentrated solution, and measure the density of the concentrated solution at 80°C to be 1.12g / ml, add ethanol equivalent to 6 times the volume of the ...
Embodiment 3
[0021] Embodiment 3: Boluohui injection according to the present invention is prepared from the following raw materials in parts by weight: 40 parts of Boluohui extract, 30 parts of polyethylene glycol, 5 parts of benzyl alcohol and glycerol 25 servings.
[0022] Its preparation method is as follows: (1) prepare the extract of Boluohui, crush Boluohui to 24 meshes, place it in a percolation device, and then add sulfuric acid with a concentration of 2% by weight equivalent to 14 times of Boluohui's weight , control the temperature at 85°C for diafiltration extraction, the diafiltration rate is 1 / 48 of the volume of sulfuric acid, collect the leachate, add sodium hydroxide solution to adjust the pH value of the leachate to 8.2, and then concentrate the leachate at 85°C to obtain The concentrated solution, the density of the concentrated solution measured at 80°C is 1.15g / ml, and ethanol equivalent to 7 times the volume of the concentrated solution is added to the concentrated so...
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