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Macleaya cordata injection and preparation thereof

A technology of Boluohui and injection, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve human health risks, bacterial veterinary drug residues, and reduce animal immunity, etc. problem, to achieve the effect of inhibiting and delaying the rise of body temperature, low cost and convenient operation

Inactive Publication Date: 2009-01-21
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the extensive use of antibiotics in recent years, the existence of beneficial microorganisms in animals has been suppressed, the immunity of animals has been reduced, and the bacteria in animals have developed drug resistance. The problem of bacterial drug resistance and veterinary drug residues The continuous emergence of human health has brought hidden dangers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Boluohui injection according to the present invention is prepared from the following raw materials in parts by weight: 30 parts of Boluohui extract, 0.5 parts of benzyl alcohol, 40 parts of ethanol and 29.5 parts of 1,2 propylene glycol .

[0018] Its preparation method is as follows: (1) prepare the extract of Boluohui, crush Boluohui to 24 meshes, place it in a percolation device, and then add sulfuric acid with a concentration of 2% by weight equivalent to 10 times of Boluohui's weight solution, control the temperature at 80°C for diafiltration extraction, the diafiltration rate is 1 / 24 of the total volume of the sulfuric acid solution collected per hour, the leachate is collected, and the pH value of the leachate is adjusted to 7.8 by adding sodium hydroxide solution , then concentrate the percolation solution at 80°C to obtain a concentrated solution, measure the density of the concentrated solution at 80°C to be 1.10g / ml, add ethanol equivalent to 5 ...

Embodiment 2

[0019] Embodiment 2: Boluohui injection according to the present invention is prepared from the following raw materials in parts by weight: 35 parts of Boluohui extract, 10 parts of polyvinylpyrrolidone, 2 parts of procaine hydrochloride and injection 53 parts of water.

[0020] Its preparation method is as follows: (1) prepare the extract of Boluohui, crush Boluohui into a coarse powder, put it in a percolation device, and then add sulfuric acid with a concentration of 2% by weight equivalent to 12 times of Boluohui's weight solution, control the temperature at 82°C for diafiltration extraction, the diafiltration rate is 1 / 36 of the volume of the sulfuric acid solution, collect the leachate, add sodium hydroxide solution to adjust the pH value of the leachate to 8.0, and then treat the leachate at 82°C Concentrate to obtain a concentrated solution, and measure the density of the concentrated solution at 80°C to be 1.12g / ml, add ethanol equivalent to 6 times the volume of the ...

Embodiment 3

[0021] Embodiment 3: Boluohui injection according to the present invention is prepared from the following raw materials in parts by weight: 40 parts of Boluohui extract, 30 parts of polyethylene glycol, 5 parts of benzyl alcohol and glycerol 25 servings.

[0022] Its preparation method is as follows: (1) prepare the extract of Boluohui, crush Boluohui to 24 meshes, place it in a percolation device, and then add sulfuric acid with a concentration of 2% by weight equivalent to 14 times of Boluohui's weight , control the temperature at 85°C for diafiltration extraction, the diafiltration rate is 1 / 48 of the volume of sulfuric acid, collect the leachate, add sodium hydroxide solution to adjust the pH value of the leachate to 8.2, and then concentrate the leachate at 85°C to obtain The concentrated solution, the density of the concentrated solution measured at 80°C is 1.15g / ml, and ethanol equivalent to 7 times the volume of the concentrated solution is added to the concentrated so...

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PUM

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Abstract

The invention provides a pink plumepoppy herb injection and a preparation method thereof; the pink plumepoppy herb injection is prepared by the raw materials with the following parts by weight: 30-40 parts of pink plumepoppy herb extract, 0-30 parts of latent solvent, 0.5-5 parts of anodyne and 25-70 parts of dispersion medium; the pink plumepoppy herb extract is prepared by the following procedure: pink plumepoppy herb is percolated with sulphuric acid, the percolate is subject to alcohol precipitation and is filtered and then ethanol is recycled; the pink plumepoppy herb injection of the invention can effectively restrain the growth of Gram-positive bacteria and has stronger bacteriostatic action than berberine, and diplococcus pneumoniae, staphylococcus aureus and bacillus subtilis are sensitive to the pink plumepoppy herb injection; meanwhile, the pink plumepoppy herb injection also has the function of resisting nematodes and leptospira and can inhibit and slow the body temperature raise caused by diplococcus pneumoniae; furthermore, the pink plumepoppy herb injection has the efficacies of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation; the indications are yellow and white scour of piglets; the preparation method has convenient operation, high yield, low cost and strong stability of finished products.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a Boluohui injection and a preparation method of the injection. Background technique [0002] From the beginning of the 1980s to the mid-1990s, my country's animal husbandry has experienced a period of rapid development, but the hazards of livestock and poultry diseases have become increasingly prominent, seriously affecting the healthy development of animal husbandry. The number of new livestock and poultry diseases is increasing, and the harm is also increasing, which not only causes serious economic losses to the breeding enterprises, but also poses a threat to the physical and mental health of consumers. However, due to the extensive use of antibiotics in recent years, the existence of beneficial microorganisms in animals has been suppressed, the immunity of animals has been reduced, and the bacteria in animals have developed drug resistance. The problem of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61K47/32A61K47/34A61P17/02A61P29/00A61P31/00A61P31/04A61P33/14A61K31/045A61K31/245A61K47/10
CPCY02A50/30
Inventor 吴红云李建正卜昌超
Owner ZHENGZHOU HOUYI PHARMA
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