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A kind of xuanmai tangerine composition and its preparation method

A technology of composition and Ophiopogon japonicus, applied in the direction of drug combination, medical formula, food science, etc., can solve the problems of poor liquid permeability, low extraction rate of effective components, high loss rate of active components, etc.

Active Publication Date: 2020-06-16
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the domestic manufacturers of Xuanmai Ganju preparations mostly use the traditional water decoction method and water extraction and alcohol precipitation method for their extraction and impurity removal processes. High, poor liquid permeability, deep color
And because the extract has not been refined, the dosage of the drug is relatively large (3-40g per day), especially the clinical efficacy needs to be further improved

Method used

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  • A kind of xuanmai tangerine composition and its preparation method
  • A kind of xuanmai tangerine composition and its preparation method
  • A kind of xuanmai tangerine composition and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Party:

[0027] Scrophulariaceae 100g Ophiopogon japonicus 100g Licorice 100g Bellflower 100g

[0028] Preparation:

[0029] Take the Scrophulariaceae medicinal material, crush it, add 800g of water to extract twice, each time for 3 hours, filter the extract, combine the extract and concentrate under reduced pressure to a relative density of 1.05-1.10 at 60°C, slowly add 95 % concentration of ethanol to make the final ethanol concentration of 75%, refrigerated precipitation for 12 hours, filtered, the filtrate was concentrated under reduced pressure to a relative density of 1.10 to 1.15 at a temperature of 60°C, and the obtained concentrate was injected into a HPD100 type macroporous adsorption resin column. 1 times the column volume for elution with purified water, and then 7 times the column volume for elution with 25% ethanol, collecting the 25% eluate, concentrating the obtained eluate under reduced pressure, and spray-drying the concentrated product to obtain the ...

Embodiment 2

[0034] Party:

[0035] Scrophulariaceae 100g Ophiopogon japonicus 100g Licorice 100g Bellflower 100g

[0036] Preparation:

[0037] Take the Scrophulariaceae medicinal material, crush it, add 600g of water to extract once, extract for 4 hours, filter the extract and concentrate under reduced pressure to a relative density of 1.05-1.10 at a temperature of 60°C, slowly add 95% ethanol under rapid stirring conditions to make the ethanol The final concentration is 60%, refrigerated and precipitated for 12 hours, filtered, and the filtrate is concentrated under reduced pressure to a relative density of 1.10 to 1.15 at a temperature of 60°C. Eluted with water, then eluted with 6 times the column volume of 20% ethanol, collected the 20% eluate, concentrated the obtained eluate under reduced pressure, and spray-dried the concentrated product to obtain the Scrophulariaceae extract;

[0038] Take Radix Ophiopogon japonicus and Radix Glycyrrhizae, crush them, add 1200g of 20% ethanol s...

Embodiment 3

[0042] Party:

[0043] Scrophulariaceae 100g Ophiopogon japonicus 100g Licorice 100g Bellflower 100g

[0044] Preparation:

[0045] Take the Scrophulariaceae medicinal material, crush it, add 1000g of water to extract 3 times, each time for 2 hours, filter the extract, combine the extract and concentrate under reduced pressure to a relative density of 1.05-1.10 at 60°C, slowly add 95 % concentration of ethanol to make the final concentration of ethanol 80%, refrigerated precipitation for 12 hours, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.10 to 1.15 at a temperature of 60°C, and the obtained concentrate was injected into a HPD100 type macroporous adsorption resin column, and first used 12 1 times the column volume for elution with purified water, and then 8 times the column volume for elution with 30% ethanol, collecting 30% of the eluate, concentrating the obtained eluate under reduced pressure, and spray-drying the concent...

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Abstract

The invention relates to a novel Xuanmaiganju composition (composition consisting of radix scrophulariae, radix ophiopogonis, liquorice root and radix platycodonis) and a preparation method of the composition. The composition is mainly prepared from 10 parts of the radix scrophulariae, 10 parts of the radix ophiopogonis, 10 parts of the liquorice root and 10 parts of the radix platycodonis; and the preparation method comprises such steps as extracting four raw materials, namely the radix scrophulariae, the radix ophiopogonis, the liquorice root and the radix platycodonis, conducting alcohol precipitation, refining extracts by virtue of a macroporous resin column and the like. Modern pharmacological researches show that both the radix scrophulariae and the radix ophiopogonis have a bacteriostatic effect and have an obvious effect on inhibiting diplococcus pneumoniae, streptococcus hemolyticus, bacillus influenzae and the like. The liquorice root has functions of resisting inflammation and resisting allergy. The radix platycodonis is capable of promoting the secretion of respiratory mucosa and taking effects of eliminating phlegm and relieving sore throat. The composition provided by the invention adopts an effective composition group, and various components fully develop a synergistic effect, so that the curative effect of the medicine (the composition) is enhanced; and animal tests show that the composition provided by the invention has a good effect of preventing and treating throat diseases.

Description

technical field [0001] The invention relates to a novel xuanmai mandarin orange composition and its preparation method and application, belonging to the field of medicine and health food. Background technique [0002] Pharyngitis is one of the common diseases in otolaryngology. According to statistics, the incidence rate accounts for about 10-20% of throat diseases. According to the length of the disease course and the nature of pathological changes, it can be divided into two categories: acute pharyngitis and chronic pharyngitis. [0003] The clinical manifestations of acute pharyngitis are as follows: acute onset, dry and burning pharynx at the beginning, and then pain. The sore throat is often more obvious when swallowing saliva than when eating; it may be accompanied by fever, headache, loss of appetite and sore limbs; Department, may be accompanied by hoarseness and coughing. Acute pharyngitis is often caused by the decline of systemic and local resistance due to cold,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P11/04A23L33/00
CPCA23V2002/00A61K36/346A61K36/484A61K36/808A61K36/8968A61K2236/331A61K2236/333A61K2236/51A61K2236/55A61K2300/00A23V2200/314
Inventor 关秀伟张纲李志刚赵淑欣胡向青孔德宪
Owner SHINEWAY PHARMA GRP LTD
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