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New molecule of PH fluorescent probe

A fluorescent probe and molecular technology, applied in the field of chemistry, can solve the problems of unsatisfactory sensitivity and inapplicability, achieve high sensitivity and expand the application field.

Inactive Publication Date: 2012-01-18
NANYANG NORMAL UNIV
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Problems solved by technology

Compared with the electrochemical method, although the background interference can be better eliminated, and the sensitivity is greatly improved, but it is applied in the field of life, because its detection range is still wide, up to 6-8 PH units, usually only Applied to the detection of physiological pH with a pH value of 6-8, for the detection of many strong acidic environments, such as gastric acid, ribozyme, lysosome, etc., there are defects that are still interfered by metal ions, the sensitivity cannot meet the requirements, and cannot be applied

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Embodiment Construction

[0016] In conjunction with the accompanying drawings and examples, the preparation method and experimental determination method of a new pH fluorescent probe molecule of the present invention are further described.

[0017] During preparation, add salicylaldehyde (2-8mmol) ethanol solution to saturated 1,8-dinaphthylamine (1-5mmol) ethanol solution, and heat the mixed solution to reflux in a water bath at 40-80°C for 5 After -30min, a light pink precipitate began to appear, continue to stir the reaction for 10-50min, and cool down to room temperature to obtain a light pink solid product, which was recrystallized with ethanol to obtain a light pink needle-like crystal—N,N'-bis(salicyl Aldehydeamino)-1,8-dinaphthylamine, which is a new molecule of PH fluorescent probe prepared by the invention, its NMR spectrum is shown in figure 1 , whose infrared spectrum is shown in figure 2 .

[0018] Fluorescence experiment: ethanol aqueous solution (solvent: ethanol / water = 1 / 9) of the ...

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Abstract

The invention, belonging to the field of chemistry, relates to a new compound, a new molecule of a PH fluorescent probe, characterized in that: a light pink acicular crystal synthesized by 1,8-dinaphthylamine and salicylaldehyde is used, the chemical name of the crystal is N,N'-bis(salicylaldehyde semicarbazone)-1,8-dinaphthylamine. Compared with the prior art, the new molecule has narrow PH response range, high sensitivity, and no background interference, and is suitable for the PH detection in strong acid environment. According to the invention, the application range is wide, especially theapplication in the life field is broadened, or has important value in precise determination of PH of cell sap in the fields of sports medicine and sports biochemistry.

Description

technical field [0001] The invention belongs to the field of chemistry and relates to a novel compound, in particular to a novel pH fluorescent probe molecule. Background technique [0002] The most commonly used method for measuring the pH value is the electrochemical method of the pH glass electrode. Due to the limitations of the glass electrode, such as interference by electricity, interference by metal ions, damage to cells, and the presence of acid errors, there are large errors and errors when the pH value is less than 1 or greater than 9. It is not suitable for defects such as pH value determination in the field of life. [0003] Fluorescent probes for the determination of pH have been reported and have been used in the fields of industry, environment and medicine. Compared with the electrochemical method, although the background interference can be better eliminated, and the sensitivity is greatly improved, but it is applied in the field of life, because its detect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C251/24C07C249/02C09K11/06G01N21/64
Inventor 黄运瑞黄豪周庆祥肖军平
Owner NANYANG NORMAL UNIV
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