Gadolinium chelated tungsten oxide fusiform nano composite material as well as preparation method and application thereof

A nano-composite material, tungsten oxide technology, applied in cyanide reaction preparation, chemical instruments and methods, tungsten oxide/tungsten hydroxide, etc., can solve the problems of not being discharged, achieve uniform size, simple operation, excellent photothermal performance effect

Active Publication Date: 2020-08-25
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the deficiencies in the prior art, the present invention discloses a gadolinium chelated tungsten oxide shuttle-shaped nanocomposite material, which has uniform size and good dispersion, and the tungsten oxide is coated with DTPA-Gd, showing remarkable optical properties. Thermal properties, and solve the problem of free Gd ions gathering in the body without being discharged. In addition, this tungsten oxide-like spindle-shaped nanocomposite material is biocompatible and has low toxicity. It has CT imaging function and can be used in the visualization of cancer. Good application potential in the field of thermal therapy

Method used

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  • Gadolinium chelated tungsten oxide fusiform nano composite material as well as preparation method and application thereof
  • Gadolinium chelated tungsten oxide fusiform nano composite material as well as preparation method and application thereof
  • Gadolinium chelated tungsten oxide fusiform nano composite material as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1 A kind of preparation method of gadolinium chelated tungsten oxide fusiform nano-composite material, comprises the following steps:

[0035] (1) Prepare W 18 o 49 :

[0036] Weigh 0.4g of tungsten chloride and dissolve it in 80mL of n-propanol, stir magnetically for about 30min until the mixed solution is orange-yellow, then transfer the mixed solution to a stainless steel reaction kettle with a polytetrafluoroethylene liner and seal it. Put it in an oven to keep warm at 180°C and keep warm for 24 hours. After the reaction is completed, cool to room temperature with the furnace, take out the reaction product and centrifuge it at 8000rpm for 10min, wash it with deionized water and absolute ethanol three times each, and place the centrifuged sediment in a vacuum drying oven. Dry at 60°C for 8h to get W 18 o 49 powder;

[0037] (2) Prepare W 18 o 49 @DTPA:

[0038] Accurately weigh 100mg of W 18 o 49 and 230mg of diethylenetriaminepentaacetic acid (D...

Embodiment 2

[0045] Embodiment 2 Photothermal Performance Research

[0046] The preparation concentration is 1mg / mLW 18 o 49 @DTPA-Gd solution, placed in a centrifuge tube, adjust the wavelength of the near-infrared laser to 808nm, and the laser power to 0.85W / cm 2 , irradiated for 10 minutes, tested the temperature of the solution every 1 minute with a temperature measuring gun and recorded the test data, and compared with pure water, the temperature rise curve of the sample was obtained as follows: Figure 4 As shown, within 1 min, the temperature of the solution rises rapidly, the temperature rises from 24.5 °C to 36.1 °C, and the temperature reaches 46.9 °C after 10 min of laser irradiation, while the temperature range of the pure water control group within 10 min is 23.9-25.3 °C, no significant warming occurred, the above results show that W 18 o 49 @DTPA-Gd has good photothermal properties, basically meeting the temperature requirements for hyperthermia treatment.

Embodiment 3

[0047] Example 3 In Vitro CT Imaging Research

[0048] At room temperature, take concentrations of 1mg / mL and 100mg / mL of W 18 o 49 @DTPA - Gd and W 18 o 49 The nanoparticle aqueous solution was placed in 2mL centrifuge tubes, and then put into the imaging instrument for testing, such as Figure 5 Shown, the concentration is 1mg / mL when W 18 o 49 @DTPA - Gd and W 18 o 49 The dark effect of the CT image of the aqueous solution is not obvious, but when the concentration increases to 100mg / mL, the brightness of the CT image is significantly improved, indicating that the CT imaging of fresh fruit depends on the concentration of the sample, indicating that W 18 o 49 @DTPA-Gd nanocomposites have good CT imaging properties.

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Abstract

The invention relates to the technical field of functional nano composite materials, and discloses a gadolinium chelated tungsten oxide fusiform nano composite material as well as a preparation methodand application thereof. The preparation method comprises the following steps of firstly synthesizing tungsten oxide by a solvothermal method; then adding the tungsten oxide and diethylenetriaminepentaacetic acid into a mixed solution of N,N-dimethylformamide and triethylamine, performing a reaction for a period of time under the protection of nitrogen, and then storing a reaction product in a Tris-HCl solution to prepare a W18O49@DTPA solution; and reacting the W18O49@DTPA solution with gadolinium nitrate hexahydrate under the protection of nitrogen to obtain the W18O49@DTPA-Gd nano composite material. The fusiform W18O49@DTPA-Gd nano composite material prepared by a microemulsion method is uniform in size and good in dispersity, the tungsten oxide is coated with DTPA-Gd to show remarkable photo-thermal performance, and the problem that free Gd ions are gathered in vivo and cannot be discharged is solved; and in addition, the fusiform nano composite material with the tungsten oxide as a matrix has the biocompatibility and the low toxicity, has a CT imaging function, and has good application potential in the field of visual photo-thermal treatment of tumors.

Description

technical field [0001] The invention relates to the technical field of functional nano-composite materials, and discloses a gadolinium-chelated tungsten oxide shuttle-shaped nano-composite material, a preparation method and application thereof. Background technique [0002] Cancer has become one of the major diseases threatening human health. Traditional treatment methods such as surgery, chemotherapy, and radiotherapy have certain limitations, and usually bring physical and mental pain to patients. Photothermal therapy is a new method that uses near-infrared laser to irradiate the tumor site, and uses the thermal effect of the photothermal conversion agent to generate high temperature to kill cancer cells. Compared with traditional therapy, it has the advantages of less trauma, high selectivity, high treatment efficiency and less toxic side effects, and it has been paid more and more attention by people. In photothermal therapy, real-time tracking and feedback of lesion s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/04A61P35/00C01G41/02B82Y5/00B82Y40/00B82Y30/00C07C227/18C07C229/76
CPCA61K41/0052A61K49/04A61P35/00C01G41/02B82Y40/00B82Y30/00B82Y5/00C07C227/18C01P2004/30C01P2004/03C01P2004/04C01P2002/72C07C229/76
Inventor 李雪姣付海洋高晓飞刘东岳
Owner HARBIN UNIV OF SCI & TECH
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