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Biodegradable magnetic nano gold shell microsphere as well as preparation method and application thereof

A magnetic nano- and micro-sphere technology, applied in the field of nano-materials, achieves good clinical application value, easy large-scale production, and simple operation

Inactive Publication Date: 2015-10-14
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Using gelatin-protected magnetic Fe3O4 microspheres as a template, and then adsorbing gold nanoparticles to obtain gold species with a dense surface, the seed growth method is used to coat the surface with a uniform gold shell, and then a biodegradable magnetic gold shell is obtained. Nanospheres have not been reported

Method used

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  • Biodegradable magnetic nano gold shell microsphere as well as preparation method and application thereof
  • Biodegradable magnetic nano gold shell microsphere as well as preparation method and application thereof
  • Biodegradable magnetic nano gold shell microsphere as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] (1) Preparation of magnetic Fe3O4 coated with gelatin

[0052] Prepare a gelatin / ethylene glycol solution with a concentration of 0.01g / mL, heat and stir to dissolve (dissolution is enough, those skilled in the art can master it by themselves), add ferric chloride and sodium acetate to the above solution in turn, and after adding The concentration of ferric chloride is 10 -2 mol / L, the concentration of sodium acetate is 10 -2 mol / L; then use ethylene glycol potassium hydroxide solution to adjust the pH value to 6, place it in a closed reaction kettle, undergo hydrothermal reaction at 140°C for 4 hours, separate by external magnetic field, wash with water and ethanol respectively, and vacuum freeze Dried to obtain a size of 50nm ferric oxide microspheres coated with gelatin on the surface, for subsequent use;

[0053] (2) Preparation of gold nanoparticles

[0054] Put 40mL deionized water in a 50mL Erlenmeyer flask, add 1mL10 -3 mol / L sodium hydroxide, 1mL10 -3 mol / ...

Embodiment 2

[0062] (1) Preparation of magnetic Fe3O4 coated with gelatin

[0063] Prepare a gelatin / ethylene glycol solution with a concentration of 0.05g / mL, heat and stir to dissolve (dissolution is enough, those skilled in the art can master it by themselves), add ferric chloride and sodium acetate to the above solution in turn, and after adding The concentration of ferric chloride is 10 -1 mol / L, the concentration of sodium acetate is 10 -1 mol / L; then adjust the pH value to 7 with a mixed solution of potassium hydroxide and sodium hydroxide of ethylene glycol, place it in a closed reaction kettle, undergo a hydrothermal reaction at 200°C for 8 hours, separate it by an external magnetic field, and separate it with water and ethanol After washing, freeze-drying in vacuum to obtain ferric oxide microspheres with a size of 80nm and gelatin coating on the surface, for subsequent use; figure 2 as shown,

[0064] (2) Preparation of gold nanoparticles

[0065] Put 40mL deionized water i...

Embodiment 3

[0073] (1) Preparation of magnetic Fe3O4 coated with gelatin

[0074] Prepare a gelatin / ethylene glycol solution with a concentration of 0.1g / mL, heat and stir to dissolve (dissolution is enough, those skilled in the art can master it by themselves), add ferric chloride and sodium acetate to the above solution in turn, and after adding The concentration of ferric chloride is 0.5mol / L, and the concentration of sodium acetate is 0.5mol / L; then the pH value is adjusted to 7 with sodium hydroxide solution of ethylene glycol, placed in a closed reaction kettle, and subjected to hydrothermal reaction at 200°C for 12 hours, separated by an external magnetic field, washed with water and ethanol respectively, and vacuum freeze-dried to obtain ferric oxide microspheres with a gelatin-coated surface with a size of 160 nm for subsequent use;

[0075] (2) Preparation of gold nanoparticles

[0076] Put 40mL deionized water in a 50mL Erlenmeyer flask, add 1mL10 -3 mol / L sodium hydroxide, 1...

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Abstract

The invention discloses a biodegradable magnetic nano gold shell microsphere as well as a preparation method and application thereof. The nano gold shell microsphere has a core-shell structure, wherein the inner core is a gelatin magnetic ferroferric oxide microsphere, and the core layer is a gold nano shell; and the diameter of the nano gold shell microsphere is 55-1000 nanometers, the diameter of the inner core is 50-800 nanometers, and the thickness of the shell layer is 5-200 nanometers. The microsphere prepared by the method disclosed by the invention is good in magnetism, narrow in particle size distribution and controllable in outer shell thickness and particle size. Because gelatin is a good in vivo biodegradable material, along with the degradation of the magnetic inner core, the outside nano gold shell layer is disintegrated into gold nano particles and is discharged out of a body at last. The preparation method is simple and convenient in process, simple to operate, low in cost and easy for large-scale production. Meanwhile, the biodegradable magnetic nano gold shell microsphere has functions of magnetic resonance targeted imaging and photo-thermal treatment, and more importantly, the biodegradability of the microsphere greatly reduces the toxic or side effects of the gold shell on human bodies, so that the biodegradable magnetic nano gold shell microsphere has a very good clinical application value.

Description

technical field [0001] The invention relates to the technical field of nanometer materials. More specifically, it relates to a biodegradable magnetic nano-gold shell microsphere and its preparation method and application. Background technique [0002] At present, cancer has become one of the main diseases that cause human death. According to the World Cancer Report 2014 by the World Health Organization, in 2012, there were more than 14 million new cases of cancer worldwide, and it is expected to reach 22 million per year in the next 20 years, while the number of cancer deaths will also soar from 8.2 million per year to 13 million. It can be seen that cancer has seriously threatened human life and health, and brought huge burden and pain to society, family and individual. In recent years, the development of nanotechnology has brought new opportunities for cancer diagnosis and treatment. Therefore, it is necessary to provide a sensitive diagnosis, effective treatment, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/14A61K41/00A61K47/42A61K9/16A61P35/00
Inventor 任俊王选东唐芳琼孟宪伟任湘菱谭龙飞
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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