65results about How to "With controlled release" patented technology

The invention discloses a preparation method for microecologics for laying hen feeds and application of the microecologics. The microecologics is prepared by uniformly mixing living microcapsules bacterium powder with selenium carrageenan, zinc methionine and auxiliary materials through a spray drying technology, wherein living microcapsules bacterium powder is obtained by uniformly mixing lactobacillus plantarum and bacillus subtilis strains with an aqueous solution containing pectin, tween-80, glycerinum, mannitol, trehalose and sodium bicarbonate after the lactobacillus plantarum and the bacillus subtilis strains are subjected to enrichment culture. The microecologics can be stored under a normal-temperature condition and is high in enteric solubility and biological adhesive. On the basis of normal daily ration, the laying hens are also fed with the microecologics, so that the anti-oxidization capability of organ bodies of laying hens can be improved; therefore, the damage degree of fallopian tubes of the laying hens in the later period of laying is reduced, excessive release of inflammatory factors in tissues can be suppressed, and the injury caused by inflammatory reaction can be alleviated; the activity and the completeness of organ tissues and cells can be guaranteed, the organ health is retained, and the productivity is improved.

The invention discloses a method for preparing therapeutic substance-loaded microcapsules. The method applies the high-voltage electrostatic spray principle and comprises the steps of leading therapeutic substance-loaded charged polymer solution to instantaneously form ultrafine gel particles under the high-voltage electrostatic action, leading a mist of the particles to be received by polymer solution charged with opposite charges, leading a surface layer of the gel particles to be wrapped by a polymer gel shell layer of the opposite charges, forming structures of capsule cores and capsule walls, further filtering by a microporous membrane, and obtaining the therapeutic substance-loaded microcapsules. Microstructures and scale of the capsule cores and the capsule walls can be precisely controlled through voltage, solution concentration and distance from a jet orifice to receiving solution, and therapeutic substances are bound by the capsule cores and the capsule walls, thereby forming controlled release and improving therapeutic efficacy. The method has the advantages of simple and feasible process and good repeatability, the whole process of the preparation process is clean and pollution-free, the provided in-situ therapeutic substance-loaded microcapsules do not need the complex post-processing, the particle size is controllable, and the release rate of the therapeutic substances is convenient to control, thereby having good application prospect.