65results about How to "With controlled release" patented technology

The invention discloses a method for preparing therapeutic substance-loaded microcapsules. The method applies the high-voltage electrostatic spray principle and comprises the steps of leading therapeutic substance-loaded charged polymer solution to instantaneously form ultrafine gel particles under the high-voltage electrostatic action, leading a mist of the particles to be received by polymer solution charged with opposite charges, leading a surface layer of the gel particles to be wrapped by a polymer gel shell layer of the opposite charges, forming structures of capsule cores and capsule walls, further filtering by a microporous membrane, and obtaining the therapeutic substance-loaded microcapsules. Microstructures and scale of the capsule cores and the capsule walls can be precisely controlled through voltage, solution concentration and distance from a jet orifice to receiving solution, and therapeutic substances are bound by the capsule cores and the capsule walls, thereby forming controlled release and improving therapeutic efficacy. The method has the advantages of simple and feasible process and good repeatability, the whole process of the preparation process is clean and pollution-free, the provided in-situ therapeutic substance-loaded microcapsules do not need the complex post-processing, the particle size is controllable, and the release rate of the therapeutic substances is convenient to control, thereby having good application prospect.