Synergistic treatment type multi-material sustained-release eye drop and preparation method

Abstract

The invention discloses a synergistic treatment type multi-material sustained-release eye drop and a preparation method. The preparation method comprises the following steps of: instantaneously forming chitosan aqueous solution which is blended with therapeutic materials into superfine gel particles under the action of direct current high voltage static; receiving the particles by using hyaluronic acid hydrosol or hyaluronic acid hydrogel; and coating the surface of chitosan particles with a hyaluronic acid gel crust layer to obtain a medicament sustained-release eye drop, wherein the size of the chitosan gel particles can be accurately controlled by controlling voltage, the concentration of the chitosan solution and the distance from a jet orifice to the liquid level of the hyaluronic acid hydrosol, and the flowability of the eye drop can be regulated by controlling the concentration of the hyaluronic acid, so that the adhesive capacity of the eye drop to the eye surface and a long-term treatment effect are improved. The preparation method has simple and practicable process, high repeatability, and clean and pollution-free whole preparation process flow; and as the provided multi-therapeutic material sustained-release eye drop for synergistic treatment on eye diseases does not need complicated process, and the proportion of each component and the release rate are convenient to control, so the preparation method has a good application prospect.

Description

technical field [0001] The invention relates to biomedicine and biomaterial technology, in particular to a synergistic therapeutic multi-substance sustained-release eye drop and a preparation method. Background technique [0002] High-voltage electrospinning technology is a new type of pollution-free preparation of nanofibers and porous films or foams that has rapidly emerged in recent years. The raw materials used in electrospinning have requirements for their spinnability. For example, pure chitosan solution is a polymer that is difficult to spin. It often forms gel particles under the action of high-voltage electrostatic field force, which is often regarded as as a worthless by-product. At the same time, high-voltage electrospinning also requires strict process parameters for the formation of nanofibers. For example, DC voltage, electric field strength, field distance, etc. need to be constantly explored to obtain limited optimization conditions before it is possible to ...

AI Technical Summary

Problems solved by technology

Chinese patent CN 100488618C discloses a method for preparing ex-situ drug-carrying liquid core microcapsules by electrostatic spraying. The patent discloses using metal calcium ions as the capsule wall forming agent for alginate microcapsules, although by using malt paste Thickeners such as essence and xanthan gum and calcium ions can lock the alginate on the capsule wall, and after the microcapsules are formed, the wall membrane is strengthened by soaking in calcium chloride solution to form a semipermeable microcapsule wall. However, in the physiological fluid environment, divalent calcium ions are prone to ion exchange with monovalent cations such as potassium and sodium ions, resulting in the rapid collapse of the microcapsule wall membrane layer, and it is difficult to maintain the controlled release and sustained release of drugs

Therefore, such materials are still difficult to meet the application of stable and sustained release of microcapsules

[0003] For a long time, the development of research on ocular drug delivery technology has been slow. Generally, they are liquids, pastes or gels. Various therapeutic substances are mixed by mechanical stirring. The release rate of the drug components is difficult to control, and due to leakage, Problems such as rapid evaporation of water lead to short dosing period, obvious peaks and valleys of drug dosage, and low bioavailability, so frequent dosing is required

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