31results about How to "High drug availability" patented technology

The invention relates to a long-acting voriconazole intraocular medicine release system which contains voriconazole and is characterized in that the intraocular medicine release system also contains biodegradable medicinal high-molecular auxiliary material; voriconazole and biodegradable medicinal high-molecular auxiliary material are mixed to form homogenized mixture; the weight ratio of biodegradable high-molecular auxiliary material and voriconazole is 0.1:0.9-0.9-0.1; the molecular weight of the biodegradable high-molecular auxiliary material is 5000-1000000Dalton. The biodegradable high-molecular auxiliary material is selected from poly(lactide-co-glycolide) and polylactic acid. The release period of the voriconazole intraocular medicine release system is a week to a year, has less medicine dosage, less times of administration, reduces the adverse reaction caused by the repeated injection of vitreous cavity and greatly improve the compliance of patients; if the vitreous body baseis implanted simultaneously during the excision operation of the central vitreous body, the complications of intraocular hemorrhage and retinal detachment caused by the repeated vitreous body puncture medicine-injection.

The invention relates to a pharmaceutical composition, and discloses an asarin pharmaceutical composition. The asarin pharmaceutical composition comprises the following components in parts by weight: 1 part of asarin, 5 to 15 parts of soybean oil, 2 to 3 parts of phospholipid, 3 to 6 parts of citric acid, 3 to 5 parts of glycerinum, and 1 to 2 parts of cysteine hydrochloride. The invention also discloses a method for processing an asarin injection using the pharmaceutical composition. By adopting the asarin pharmaceutical composition, the solubilization effect of the asarin injection can be improved, and the content stability can be raised. The asarin pharmaceutical composition solution is close to a true solution. The preparation method of the asarin injection is simple and applicable to industrial production.

The invention relates to the field of medicine and discloses a traditional Chinese medicine, specifically a Sophora flavescens powder and a preparation method and application thereof. The Sophora flavescens powder is mainly prepared by pelletizing a particle and a second adhesive. The particle is prepared by pelletizing Sophora flavescens fine powder and a first adhesive, wherein the first adhesive contains acrylic resin No.VI. The second adhesive contains one or more ingredients selected from a group consisting of xanthan gum, crosslinked periston, a licorice fluid extract and sodium dodecyl sulfate. By using acrylic resin No.VI for the first adhesive and by adding the second adhesive as a compounding component for forming synergism for gluing and pelletizing, the Sophora flavescens powder will not be disintegrated or slightly disintegrated in an aqueous solution and saliva during the production and application process. Thus, palatability during forage intake of livestock is enhanced, bioavailability is increased, functions are improved, and the application range for animals is widened.

The invention discloses a synergistic treatment type multi-material sustained-release eye drop and a preparation method. The preparation method comprises the following steps of: instantaneously forming chitosan aqueous solution which is blended with therapeutic materials into superfine gel particles under the action of direct current high voltage static; receiving the particles by using hyaluronic acid hydrosol or hyaluronic acid hydrogel; and coating the surface of chitosan particles with a hyaluronic acid gel crust layer to obtain a medicament sustained-release eye drop, wherein the size ofthe chitosan gel particles can be accurately controlled by controlling voltage, the concentration of the chitosan solution and the distance from a jet orifice to the liquid level of the hyaluronic acid hydrosol, and the flowability of the eye drop can be regulated by controlling the concentration of the hyaluronic acid, so that the adhesive capacity of the eye drop to the eye surface and a long-term treatment effect are improved. The preparation method has simple and practicable process, high repeatability, and clean and pollution-free whole preparation process flow; and as the provided multi-therapeutic material sustained-release eye drop for synergistic treatment on eye diseases does not need complicated process, and the proportion of each component and the release rate are convenient to control, so the preparation method has a good application prospect.

The invention relates to a polyvinyl alcohol hydrogel and a preparation method and application thereof, belonging to the technical field of polymer hydrogels. In the present invention, oridin is added dropwise to sodium alginate microsphere solution, and after treatment, oridin / sodium alginate microsphere complex is obtained; polyethyleneimine derivative carrier is prepared by EDC / NHS activation reaction for loading micro RNA; finally, the oridin / sodium alginate microsphere complex, microRNA / polyethyleneimine derivative carrier and polyvinyl alcohol solution are uniformly mixed, and then freeze-thawed repeatedly to form a hydrogel material. The hydrogel loaded with oridin / sodium alginate microsphere complex and microRNA / polyethyleneimine derivative carrier of the present invention has the functions of drug slow release and microRNA regulation, and can improve the drug availability of oridinin , and has the effect of gene therapy, and can be applied in skin wound dressings.