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Drug-coating balloon catheter and production method and application thereof
ActiveCN107362439ANot easy to wash offHigh drug loading efficiencyBalloon catheterMedical devicesDrugs solutionDrug crystals
The invention provides a drug-coating balloon catheter and a production method and application thereof. The method includes: preparing active drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active drug seed crystal suspension; adding the active drug seed crystal suspension, an active drug solution and an additive solution into different channels of a coating machine, mixing and atomizing the active drug seed crystal suspension, the active drug solution and the additive solution at the nozzle tip end of the ultrasonic sprayer of the coating machine, spraying to the surface of a balloon dilatation catheter to obtain drug coating with an appropriate crystal size, and performing homogenizing post-processing to obtain the drug-coating balloon catheter with homogeneous crystals. The drug-coating balloon catheter and the production method thereof have the advantages that the drug coating is firmly combined with a balloon, and drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the blood vessel wall of a lesion part is high, high drug loading efficiency is achieved, intravascular in-situ stenosis or restenosis can be treated effectively, the risks of late thrombosis and restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.
Owner:LEPU MEDICAL TECH (BEIJING) CO LTD
Synergistic treatment type multi-material sustained-release eye drop and preparation method
ActiveCN101816627AWith controlled releaseDry fastSenses disorderPharmaceutical delivery mechanismHYDROSOLHigh pressure
The invention discloses a synergistic treatment type multi-material sustained-release eye drop and a preparation method. The preparation method comprises the following steps of: instantaneously forming chitosan aqueous solution which is blended with therapeutic materials into superfine gel particles under the action of direct current high voltage static; receiving the particles by using hyaluronic acid hydrosol or hyaluronic acid hydrogel; and coating the surface of chitosan particles with a hyaluronic acid gel crust layer to obtain a medicament sustained-release eye drop, wherein the size of the chitosan gel particles can be accurately controlled by controlling voltage, the concentration of the chitosan solution and the distance from a jet orifice to the liquid level of the hyaluronic acid hydrosol, and the flowability of the eye drop can be regulated by controlling the concentration of the hyaluronic acid, so that the adhesive capacity of the eye drop to the eye surface and a long-term treatment effect are improved. The preparation method has simple and practicable process, high repeatability, and clean and pollution-free whole preparation process flow; and as the provided multi-therapeutic material sustained-release eye drop for synergistic treatment on eye diseases does not need complicated process, and the proportion of each component and the release rate are convenient to control, so the preparation method has a good application prospect.
Owner:ZHEJIANG UNIV
Chaihuang Tonic and its preparation method
InactiveCN1579434APromote absorptionHigh drug availabilityUnknown materialsAntiinfectivesSide effectRespiratory tract disease
The invention discloses a bupleurum root oral liquid and its manufacturing method, which relates to a Chinese traditional medicine and its manufacturing method, especially a Chinese traditional medicine for curing wind heat and cold and its manufacturing method. It uses bupeurum root, large-flowered skullcap root, cane sugar as material to produce the medicine with current medicine processing technology. The product is produced according to national traditional medical theory, the product is convenient, quick, and has no toxin and side effects, it can be applied to prevent and cure upper respiratory tract diseases.
Owner:FUJIAO GROUP CORP SHANDONG
Nano-gold-coated layered double hydroxide composite material and its preparation method and use
ActiveCN105251012APH sensitiveHigh drug loadingOrganic active ingredientsInorganic non-active ingredientsGold particlesIn vivo
The invention relates to a nano-gold-coated layered double hydroxide composite material and its preparation method and use. The composite material has a core-shell structure and comprises double hydroxide particles coated with nano-gold particles, the average particle size of the nano-gold particles is less than 5nm, and the particle size of the double hydroxide particles is in a range of 20-200nm. The nano-gold-coated layered double hydroxide composite material can be used for drug delivery. Compared with the existing double hydroxide composite material, the nano-gold-coated layered double hydroxide composite material has pH sensitivity, high drug load and internal field circularity. The surface of the nano-gold-coated layered double hydroxide composite material can be subjected to positive and negative modification, be connected to a ligand and an antibody, and be subjected to amination, carboxylation and formylation. The nano-gold-coated layered double hydroxide composite material can be used as a drug carrier, realizes targeting and slow release in vivo, and improves drug in-vivo cycle time, a drug utilization degree and drug targeting effects.
Owner:TONGJI UNIV
Intra-ocular release system of voriconazole
InactiveCN101390825BReduce dosageReduce the number of dosesOrganic active ingredientsSenses disorderLactideVitreous base
The invention relates to a long-acting voriconazole intraocular medicine release system which contains voriconazole and is characterized in that the intraocular medicine release system also contains biodegradable medicinal high-molecular auxiliary material; voriconazole and biodegradable medicinal high-molecular auxiliary material are mixed to form homogenized mixture; the weight ratio of biodegradable high-molecular auxiliary material and voriconazole is 0.1:0.9-0.9-0.1; the molecular weight of the biodegradable high-molecular auxiliary material is 5000-1000000Dalton. The biodegradable high-molecular auxiliary material is selected from poly(lactide-co-glycolide) and polylactic acid. The release period of the voriconazole intraocular medicine release system is a week to a year, has less medicine dosage, less times of administration, reduces the adverse reaction caused by the repeated injection of vitreous cavity and greatly improve the compliance of patients; if the vitreous body baseis implanted simultaneously during the excision operation of the central vitreous body, the complications of intraocular hemorrhage and retinal detachment caused by the repeated vitreous body puncture medicine-injection.
Owner:SHANDONG EYE INST
Compound herbal antibacterial liquid as well as preparation process and application thereof
PendingCN113332350AQuick resultsQuickly detoxify and reduce swellingAntibacterial agentsAntimycoticsChlorhexidine AcetateChlorhexidine
The invention provides compound herbal antibacterial liquid as well as a preparation process and application thereof. The compound herbal antibacterial liquid comprises the following raw materials: a medicinal plant leachate, sesame oil, borneol, peppermint oil, chlorhexidine acetate, coptis chinensis, scutellaria baicalensis, golden cypress, sanguisorba officinalis, rheum officinale, catechu and peppermint oil. The preparation process comprises the following steps: adding the coptis chinensis, the scutellaria baicalensis, the golden cypress, the sanguisorba officinalis, the rheum officinale and the catechu which are crushed into the peppermint oil, performing stirring, performing dipping and performing extracting for one month to obtain the medicinal plant leachate; taking out small medicine bags, adding the sesame oil, the borneol and the chlorhexidine acetate, performing uniform stirring, and finally performing filling and packaging. The compound herbal antibacterial liquid is an external antibacterial liquid with complete functions, can be at least used for treating scalp tinea, scald, mosquito bite, knife injury, fall injury, carbuncle, surgical scars and acne, is high in medicine availability, is not limited by age, gender and race, and is safe and reliable. Particularly, the compound herbal antibacterial liquid i has the advantages of quick detoxification and detumescence, quick tissue regeneration and close-up, quick pus extraction and poison drawing, quick incrustation and pain relief, quick astringency and hemostasis, and quick insect killing and itching relieving.
Owner:重庆兴皕堂生物科技有限公司
Oral traditional Chinese medicine film agent and method for preparing same
InactiveCN108030862AImprove curative effectHigh drug availabilityHydroxy compound active ingredientsDigestive systemPharmaceutical preservativesTraditional Chinese medicine
The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly discloses an oral traditional Chinese medicine film agent and a method for preparing the same. The oral traditional Chinese medicine film agent mainly comprises, by weight, 5-70 parts of raw materials and 30-100 parts of excipients. The oral traditional Chinese medicine film agent prepared bythe aid of the method is a square laminar film with the area of 1 cm<2>. The oral traditional Chinese medicine film agent and the method have the advantages that the oral traditional Chinese medicinefilm agent can be attached to the surfaces of mucosas, accordingly, effects of protecting the mucosas can be realized, site-specific delivery can be carried out on medicines, and curative effects canbe improved.
Owner:青岛恒新辉瑞工业技术有限公司
Preparation method of drug-coated balloon catheter, prepared drug-coated balloon catheter and application thereof
ActiveCN107362439BNot easy to wash offHigh drug loading efficiencyBalloon catheterMedical devicesDrugs solutionThrombus
The invention provides a drug-coating balloon catheter and a production method and application thereof. The method includes: preparing active drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active drug seed crystal suspension; adding the active drug seed crystal suspension, an active drug solution and an additive solution into different channels of a coating machine, mixing and atomizing the active drug seed crystal suspension, the active drug solution and the additive solution at the nozzle tip end of the ultrasonic sprayer of the coating machine, spraying to the surface of a balloon dilatation catheter to obtain drug coating with an appropriate crystal size, and performing homogenizing post-processing to obtain the drug-coating balloon catheter with homogeneous crystals. The drug-coating balloon catheter and the production method thereof have the advantages that the drug coating is firmly combined with a balloon, and drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the blood vessel wall of a lesion part is high, high drug loading efficiency is achieved, intravascular in-situ stenosis or restenosis can be treated effectively, the risks of late thrombosis and restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.
Owner:LEPU MEDICAL TECH (BEIJING) CO LTD
Traditional Chinese medicine composition for treating infantile cough asthma and preparation method thereof
InactiveCN105998374AImprove stabilityGood curative effectAnthropod material medical ingredientsRespiratory disorderDrug availabilitySide effect
The invention relates to a traditional Chinese medicine composition for treating infantile cough asthma and a preparation method thereof. The traditional Chinese medicine composition comprises the following bulk drugs in parts by weight: 8-12 parts of radix peucedani, 8-12 parts of Chinese galls, 8-12 parts of tingli seeds, 8-12 parts of balloonflower root, 8-12 parts of cortex lycii radicis, 8-12 parts of mulberry bark, 8-12 parts of donkey-hide gelatin, 5-7 parts of inula Britannica, 5-7 parts of clamshell, 5-7 parts of arctium fruit, 5-7 parts of dark plum, and 5-7 parts of coptis. The traditional Chinese medicine composition has the advantages of good curative effect, fast effectiveness, no side effect, advanced preparation technology, good preparation stability, and high drug availability; through clinical verification, the effective rate of the traditional Chinese medicine composition for treating infantile pneumonia is 96%.
Owner:华梅
Traditional Chinese medicine aerosol for preventing and treating infantile cold asthma
InactiveCN106138959AEasy dischargeImprove immunityAerosol deliveryRespiratory disorderDrug availabilityLicorice roots
The invention discloses a traditional Chinese medicine aerosol for preventing and treating infantile cold asthma. The traditional Chinese medicine aerosol is mainly prepared from honey-fried herba ephedrae, fructus schisandrae chinensis, fructus perillae, rhizoma cynanchi stauntonii, raw folium artemisiae argyi, folium eriobotryae, ramulus cinnamomi, apricot kernels, exocarpium citri rubrum, fried pheretima, folium pyrrosiae, rhizoma polygoni cuspidati, fructus citri, radix angelicae dahuricae, fistular onion stalks, folium mori, cardamom and licorice roots. The traditional Chinese medicine aerosol has the comprehensive effects of regulating and enhancing body immunity, resisting inflammation and allergies, reducing bronchial hyperresponsiveness and improving microcirculation, the relapse of the asthma is delayed, the stage of attack is delayed, the aerosol can directly act on tunica mucosa bronchiorum, and the local drug concentration is high; meanwhile, aerosol inhalation can humidify respiratory tracts and benefit secretion drainage, the drug availability is high, toxic and side effects are small, use is convenient, and the aerosol takes effect quickly and is worthy of clinical application and popularization.
Owner:刘黎明
Asarum medicinal composition and preparation method thereof
ActiveCN103550153BEasy to prepareHigh drug availabilityNervous disorderEther/acetal active ingredientsCysteine HydrochlorideAsarone
The invention relates to a pharmaceutical composition, and discloses an asarin pharmaceutical composition. The asarin pharmaceutical composition comprises the following components in parts by weight: 1 part of asarin, 5 to 15 parts of soybean oil, 2 to 3 parts of phospholipid, 3 to 6 parts of citric acid, 3 to 5 parts of glycerinum, and 1 to 2 parts of cysteine hydrochloride. The invention also discloses a method for processing an asarin injection using the pharmaceutical composition. By adopting the asarin pharmaceutical composition, the solubilization effect of the asarin injection can be improved, and the content stability can be raised. The asarin pharmaceutical composition solution is close to a true solution. The preparation method of the asarin injection is simple and applicable to industrial production.
Owner:深圳朗欧医药集团有限公司
Traditional Chinese medicine composition for treatment of infantile convulsion and preparation method of same
InactiveCN107281371AImprove stabilityImprove utilizationHeavy metal active ingredientsNervous disorderConvulsionSide effect
The invention relates to a traditional Chinese medicine composition for treatment of infantile convulsion and a preparation method of same. The traditional Chinese medicine composition is prepared from raw material medicines including, by weight, 18-22 parts of Chinese rhubarb, 18-22 parts of eretmochelys imbricata, 18-22 parts of herba schizonepetae, 18-22 parts of mangnolia officinalis, 13-17 parts of thunberg fritillary bulbs, 13-17 parts of pericarpium citri reticulatae, 13-17 parts of divaricate saposhnikovia root, 13-17 parts of rhizoma chuanxiong, 8-12 parts of tangerine peel, 8-12 parts of ochre, 8-12 parts of cinnabar, 8-12 parts of codonopsis pilosula, 8-12 parts of honey suckles, 8-12 parts of apricot kernels, 8-12 parts of cape jasmine, 8-12 parts of coptis chinensis, 5-7 parts of notopterygium roots, 5-7 parts of radix angelicae pubescentis, 5-7 parts of Chinese ephedra, 5-7 parts of angelica sinensis, 5-7 parts of white peony roots, and 5-7 parts of fructus lycii. The traditional Chinese medicine composition has good and quick curative effects, is free of side effects and has advanced preparation process, good preparation stability and high availability. Clinical test proves that the traditional Chinese medicine composition reaches 92.5% in effective rate for treatment of the infantile convulsion.
Owner:朱克兰
Pharmaceutical composition containing cavidine total alkali and preparation method of pharmaceutical composition
ActiveCN103919743BGood disintegrationGood dissolution effectOrganic active ingredientsPill deliveryDehydrogenationDissolution
The invention provides a pharmaceutical composition containing cavidine total alkali. The pharmaceutical composition is a dispersible tablet which comprises dehydrogenation cavidine alkaloid and pharmaceutical adjuvants. The composition comprises 1-300 parts of cavidine total alkali. The pharmaceutical adjuvants comprise 10-200 parts of a disintegrating agent, 0.1-10 parts of a lubricant, 0.1-10 parts of flow aid, 0-200 parts of filler, 0-100 parts of a binder, 0-200 parts of a sweller, 0-50 parts of a surfactant and 0-200 parts of a sweetening agent. The pharmaceutical composition (dispersible tablet) containing cavidine total alkali solves the problem that indissolvable drugs are low in dissolution rate, has good disintegration and dissolution performance as well as good dispersion uniformity and taste and is convenient to take and good in compliance. The medicine availability is remarkably improved, the onset time is accelerated and the effect is more remarkable.
Owner:GUANGZHOU YIPINHONG PHARMA +4
Chinese medicinal capsules for treating psoriasis, multiple kinds of stubborn dermatitis and pruritus
InactiveCN101926913AHigh drug availabilitySignificant effectAnthropod material medical ingredientsCapsule deliveryPsoriasisMedicinal herbs
Owner:HEILONGJIANG HENGFA PHARMA
Sophora flavescens powder and its preparation method and application
ActiveCN106902147BDisintegration controllableGood curative effectAntibacterial agentsDigestive systemBiotechnologyAcrylic resin
The invention relates to the field of medicine and discloses a traditional Chinese medicine, specifically a Sophora flavescens powder and a preparation method and application thereof. The Sophora flavescens powder is mainly prepared by pelletizing a particle and a second adhesive. The particle is prepared by pelletizing Sophora flavescens fine powder and a first adhesive, wherein the first adhesive contains acrylic resin No.VI. The second adhesive contains one or more ingredients selected from a group consisting of xanthan gum, crosslinked periston, a licorice fluid extract and sodium dodecyl sulfate. By using acrylic resin No.VI for the first adhesive and by adding the second adhesive as a compounding component for forming synergism for gluing and pelletizing, the Sophora flavescens powder will not be disintegrated or slightly disintegrated in an aqueous solution and saliva during the production and application process. Thus, palatability during forage intake of livestock is enhanced, bioavailability is increased, functions are improved, and the application range for animals is widened.
Owner:绿色食品(海南自贸区)集团有限公司 +1
Traditional Chinese medicine composition for treating halitosis and preparation method of traditional Chinese medicine composition for treating halitosis
InactiveCN106138694AImprove stabilityGood curative effectDigestive systemAluminium/calcium/magnesium active ingredientsCannabisSide effect
The invention relates to a traditional Chinese medicine composition for treating halitosis and a preparation method of the traditional Chinese medicine composition for treating halitosis. The traditional Chinese medicine composition is prepared from, by weight, 18-22 parts of Fructus Forsythiae, 18-22 parts of Semen Pruni, 18-22 parts of Semen Myristicae, 11-13 parts of gypsum, 11-13 parts of Radix et Rhizoma Rhei, 11-13 parts of Cortex Dictamni, 11-13 parts of ginseng, 6-8 parts of Cortex Mori, 6-8 parts of Cortex Lycii, 6-8parts of Radix Ophiopogonis, 6-8 parts of Radix Rehmanniae, 6-8 parts of Cortex Moutan, 6-8 parts of Radix Paeoniae Rubra, 6-8 parts of Fructus Aurantii, 2-4 parts of Fructus Schisandrae Chinensis, 2-4 parts of Flos Inulae, 2-4 parts of Fructus Cannabis and 2-4 parts of Fructus Lycii. The traditional Chinese medicine composition has advantages of excellent curative effects, quick action, freeness of side effects, advanced preparation process, high preparation stability, high medicine availability and the like. According to clinical verifications, the effective rate of the traditional Chinese medicine composition is 100% in halitosis treatment.
Owner:华梅
Traditional Chinese medicine composition for treating nasal polyp, and preparation method thereof
InactiveCN106039135AImprove stabilityGood curative effectAnthropod material medical ingredientsAlgae medical ingredientsDrug availabilitySide effect
The invention relates to a traditional Chinese medicine composition for treating nasal polyp and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following bulk drugs by weight: 28 to 32 parts of oyster, 28 to 32 parts of coix seeds, 13 to 17 parts of Prunella vulgaris, 13 to 17 parts of Radix Codonopsis, 13 to 17 parts of Zhejiang fritillaria bulb, 13 to 17 parts of bitter orange fruit, 13 to 17 parts of kelp, 8 to 12 parts of peach seed, 8 to 12 parts of safflower, 8 to 12 parts of pinellia tuber, 8 to 12 parts of Arisaema cum Bile, 8 to 12 parts of Chinese honey locust spine, 8 to 12 parts of muscardine silkworm, 8 to 12 parts of safflower, 8 to 12 parts of root of large-flowered skullcap, 8 to 12 parts of loquat leaf, 5 to 7 parts of clove, 5 to 7 parts of Radix bupleuri, 5 to 7 parts of dried orange peel, 5 to 7 parts of akebia stem and 2 to 4 parts of Asarum herb. The traditional Chinese medicine composition has the advantages of good curative effect, fast action, no side effect, good stability, high drug availability, etc.; the preparation method is advanced; and clinical verification proves that the traditional Chinese medicine composition has an effective rate of 93% in treatment of nasal polyp.
Owner:华梅
Dehydrocavidine-containing pharmaceutical composition and preparation method thereof
ActiveCN103933037BGood disintegrationGood dissolution effectOrganic active ingredientsPill deliveryDehydrocavidineAdhesive
The invention provides a dehydrocavidine-containing pharmaceutical composition. The pharmaceutical composition is in a form of dispersible tablet and comprises 1 to 150 parts by weight of dehydrocavidine and pharmaceutical excipients, wherein the pharmaceutical excipients comprise 10 to 200 parts by weight of disintegrating agent, 0.1 to 10 parts by weight of lubricating agent, 0.1 to 10 parts of flow aid, 0 to 200 parts of filling agent, 0 to 100 parts of adhesive, 0 to 200 parts of swelling agent, 0 to 50 parts of surface active agent, and 0 to 200 parts of corrigent. The dehydrocavidine-containing pharmaceutical composition (dispersible tablet) solves the problem of low dissolution rate of dehydrocavidine, and is high in disintegrative performance and dissolution performance, outstanding in dispersing uniformity, great in taste, convenient to take, high in adaptability, highly obvious in drug utilization rate, fast to act, and obvious in medical function.
Owner:GUANGZHOU YIPINHONG PHARMA +4
Traditional Chinese medicine composition for treating chronic periodontitis and preparation method thereof
InactiveCN105998884AImprove stabilityGood curative effectDigestive systemPlant ingredientsDrug availabilitySide effect
The invention relates to a traditional Chinese medicine composition for treating chronic periodontitis and a preparation method thereof. The traditional Chinese medicine composition comprises the following bulk drugs in parts by weight: 28-32 parts of yerbadetajo herb, 18-22 parts of raw rehmannia root, 18-22 parts of radices trichosanthis, 13-17 parts of tree peony bark, 13-17 parts of fructus forsythia, 13-17 parts of Chinese angelica, 8-12 parts of anemarrhena, 8-12 parts of dendrobium, 8-12 parts of radix ophiopogonis, 8-12 parts of rhizoma cimicifugae, 8-12 parts of rheum officinale, 8-12 parts of spine date seed, 5-7 parts of licorice, 5-7 parts of gentrin knotweed, 5-7 parts of coptis, and 5-7 parts of lophatherum gracile. The traditional Chinese medicine composition has the advantages of good curative effect, fast effectiveness, no side effect, advanced preparation technology, good preparation stability, and high drug availability; through clinical verification, the effective rate of the traditional Chinese medicine composition for treating infantile pneumonia is 97%.
Owner:华梅
Asarin pharmaceutical composition and preparation method of injection of asarin pharmaceutical composition
ActiveCN103550153AEasy to prepareHigh drug availabilityNervous disorderEther/acetal active ingredientsMedicineCysteine Hydrochloride
The invention relates to a pharmaceutical composition, and discloses an asarin pharmaceutical composition. The asarin pharmaceutical composition comprises the following components in parts by weight: 1 part of asarin, 5 to 15 parts of soybean oil, 2 to 3 parts of phospholipid, 3 to 6 parts of citric acid, 3 to 5 parts of glycerinum, and 1 to 2 parts of cysteine hydrochloride. The invention also discloses a method for processing an asarin injection using the pharmaceutical composition. By adopting the asarin pharmaceutical composition, the solubilization effect of the asarin injection can be improved, and the content stability can be raised. The asarin pharmaceutical composition solution is close to a true solution. The preparation method of the asarin injection is simple and applicable to industrial production.
Owner:深圳朗欧医药集团有限公司
Preparation quickly treating toothache
InactiveCN108186778APain relieverWide variety of sourcesNervous disorderDigestive systemRadix AconitiDentin hypersensitivity
The invention provides a preparation quickly treating toothache. The preparation is prepared from, by weight, 9-18 parts of radix aconiti, 9-18 parts of radix linderae, 6-15 parts of radix paeoniae alba, 5-10 parts of radix angelicae pubescentis, 3-6 parts of Sichuan pepper and 9-20 parts of senecio scandens, and all the raw materials are soaked in a certain weight part of baijiu. Through the principle of warming the channels to relieve pain, nourishing blood to restore promoting the menstrual flow, killing parasites to relieve itching, cooling blood for improving eyesight, warming the middleto relieve pain and promoting qi circulation to relieve pain, the symptoms of neurogenic toothache, dentin hypersensitivity, dental caries and gingival inflammation, red and swelling are treated, andthe effect of quick pain relieving is achieved.
Owner:金耀荣
Synergistic treatment type multi-material sustained-release eye drop and preparation method
ActiveCN101816627BWith controlled releaseDry fastSenses disorderPharmaceutical delivery mechanismHYDROSOLHigh pressure
Owner:ZHEJIANG UNIV
Integrated equipment for dendrobium huoshanense juice processing, grinding and mixing
InactiveCN113171825AHigh drug availabilityIncrease dissociation rateGrain treatmentsMetal working apparatusStructural engineeringElectric equipment
The invention discloses integrated equipment for dendrobium huoshanense juice processing, grinding and mixing. The integrated equipment comprises a machine body and electrical equipment, wherein a conical working groove and a discharging groove formed in the bottom of the working groove are formed in the machine body; a working shaft moving up and down is rotationally arranged in the working groove, the working shaft is conical, and a plurality of additional rings in contact connection with the groove wall of the working groove are fixed on the conical surface of the working shaft; a cover plate is fixed to the top of the working groove, a cutter rod and a hammer rod which synchronously move up and down are arranged above the machine body, and an impact hammer is fixed to the bottom of the hammer rod; a liquid outlet pipe and a residue outlet pipe which are symmetrically arranged communicate with the groove wall of the discharging groove, the liquid outlet pipe communicates with a filter box, and the residue outlet pipe communicates with a drying box; and a feeding hole communicating with the working groove is formed in one side of the machine body. According to the equipment, grinding, filtering and drying of dendrobium nobile are integrated in one piece of equipment, and the fresh dendrobium nobile is dissociated into dendrobium nobile juice and dried dendrobium nobile, so that the integration degree of the equipment is high, the dissociation degree is high, waste is reduced, high processing efficiency is guaranteed, and the medicinal utilization degree of the fresh dendrobium nobile is also high.
Owner:安徽霍山鹏泽生物科技有限公司
A kind of polyvinyl alcohol hydrogel and its preparation method and application
ActiveCN109675095BHigh drug availabilityHas the effect of gene therapyOrganic active ingredientsAerosol deliveryMicrosphereDrug release
The invention relates to a polyvinyl alcohol hydrogel and a preparation method and application thereof, belonging to the technical field of polymer hydrogels. In the present invention, oridin is added dropwise to sodium alginate microsphere solution, and after treatment, oridin / sodium alginate microsphere complex is obtained; polyethyleneimine derivative carrier is prepared by EDC / NHS activation reaction for loading micro RNA; finally, the oridin / sodium alginate microsphere complex, microRNA / polyethyleneimine derivative carrier and polyvinyl alcohol solution are uniformly mixed, and then freeze-thawed repeatedly to form a hydrogel material. The hydrogel loaded with oridin / sodium alginate microsphere complex and microRNA / polyethyleneimine derivative carrier of the present invention has the functions of drug slow release and microRNA regulation, and can improve the drug availability of oridinin , and has the effect of gene therapy, and can be applied in skin wound dressings.
Owner:GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
Mycophenolate mofetil intraocular medicament releasing system
InactiveCN101590010AHigh drug availabilityIncrease local concentrationOrganic active ingredientsPill deliveryWhole bodyMedicine
The invention relates to a mycophenolate mofetil intraocular medicament releasing system, which comprises mycophenolate mofetil. The system is characterized by also comprising a biodegradable macromolecule auxiliary material, wherein the mycophenolate mofetil and biodegradable medicinal macromolecule auxiliary material form a homogeneous mixture together; the weight ratio of the biodegradable macromolecule auxiliary material to the mycophenolate mofetil is 0.4:0.6-0.6:0.4; and the molecular weight of the biodegradable medicinal macromolecule auxiliary material is between 10,000 and 100,000 daltons. The biodegradable medicinal macromolecule auxiliary material is made of one of lactide-glycolide, polylactic acid, and polylactic acid-glycollic acid. The medicament releasing cycle of the system is a week or half a year, and the system has the advantages of little dosage, low drug administration frequency, high medicament utilization degree, high local concentration and lasting medicine effect, and reduction of the dosage of the whole body and the complications.
Owner:SHANDONG EYE INST
Nano-gold coated layered double hydroxide composite material and its preparation and application
ActiveCN105251012BPH sensitiveHigh drug loadingOrganic active ingredientsInorganic non-active ingredientsDrug availabilityAntiendomysial antibodies
The invention relates to a nano-gold-coated layered double hydroxide composite material and its preparation and application. The composite material has a core-shell structure, double hydroxide particles wrapped with nano-gold particles on the outside, and the average particle diameter of the nano-gold particles Less than 5nm, the particle size of double hydroxide particles is 20‑200nm, which can be applied to drug delivery. Compared with the prior art, the composite material prepared by the present invention has pH sensitivity, high drug loading capacity, field circulation in vivo, surface potential can be positively and negatively modified, and the surface can link ligands, antibodies, amination, carboxylation, Formylation, used as a drug carrier, achieves the dual effects of targeting and sustained release in vivo, and improves the drug's in vivo circulation time, drug availability, and drug targeting.
Owner:TONGJI UNIV
Preparation method of injectable hydrogel for controlled release of voriconazole intraocular drug
ActiveCN108434093BRelieve painReduce economyOrganic active ingredientsSenses disorderOphthalmologyCyclodextrin
The invention discloses a preparation method for injectable hydrogel for controlled release of a voriconazole intraocular drug, and relates to the preparation method for injectable hydrogel. The preparation method aims to solve the problems that an existing voriconazole preparation is fast in metabolism and needs to be repeatedly supplied, the body pain and economic burden of a patient are increased, and an existing voriconazole sustained release system is poor in biocompatibility and poor in long-acting controlled-release effect. The method comprises the following steps of 1, preparing whiteflocculent polyaldehyde dextran; 2, preparing water-soluble linear poly-beta-cyclodextrin; and 3, firstly preparing a PBS solution of the water-soluble linear poly-beta-cyclodextrin with voriconazoleloaded in a cyclodextrin molecular cage, and then dissolving carboxymethyl chitosan into the PBS solution so as to obtain the injectable hydrogel for controlled release of the voriconazole intraoculardrug. According to the preparation method, the half-life of the prepared injectable hydrogel for controlled release of the voriconazole intraocular drug in a vitreous cavity is 30-60 days; and the injectable hydrogel for controlled release of the voriconazole intraocular drug can be obtained.
Owner:QINGDAO UNIV
Dehydrocavidine-containing pharmaceutical composition and preparation method thereof
ActiveCN103933037ADissolution rate is fastImprove bioavailabilityOrganic active ingredientsPharmaceutical non-active ingredientsDehydrocavidineAdhesive
The invention provides a dehydrocavidine-containing pharmaceutical composition. The pharmaceutical composition is in a form of dispersible tablet and comprises 1 to 150 parts by weight of dehydrocavidine and pharmaceutical excipients, wherein the pharmaceutical excipients comprise 10 to 200 parts by weight of disintegrating agent, 0.1 to 10 parts by weight of lubricating agent, 0.1 to 10 parts of flow aid, 0 to 200 parts of filling agent, 0 to 100 parts of adhesive, 0 to 200 parts of swelling agent, 0 to 50 parts of surface active agent, and 0 to 200 parts of corrigent. The dehydrocavidine-containing pharmaceutical composition (dispersible tablet) solves the problem of low dissolution rate of dehydrocavidine, and is high in disintegrative performance and dissolution performance, outstanding in dispersing uniformity, great in taste, convenient to take, high in adaptability, highly obvious in drug utilization rate, fast to act, and obvious in medical function.
Owner:GUANGZHOU YIPINHONG PHARMA +4
Traditional Chinese medicine composition for treating glaucoma and preparation method thereof
InactiveCN106039097AImprove stabilityGood curative effectSenses disorderPteridophyta/filicophyta medical ingredientsDrug availabilitySide effect
The invention relates to a traditional Chinese medicine composition for treating glaucoma and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following bulk drugs by weight: 28 to 32 parts of Rhizoma Imperatae, 18 to 22 parts of Radix Codonopsis, 18 to 22 parts of motherwort, 18 to 22 parts of lotus leaf, 13 to 17 parts of tree peony bark, 13 to 17 parts of Chinese yam, 13 to 17 parts of oyster, 13 to 17 parts of Chinese magnoliavine fruit, 13 to 17 parts of Chinese rhubarb, 13 to 17 parts of Rhizoma Gastrodiae, 13 to 17 parts of dark plum, 8 to 12 parts of evodia fruit, 8 to 12 parts of Tribulus terrstris, 8 to 12 parts of red peony root, 8 to 12 parts of equisetum, 8 to 12 parts of safflower, 8 to 12 parts of glehnia root, 8 to 12 parts of toosendan fruit, 8 to 12 parts of Chinese gentian, 5 to 7 parts of ricepaperplant pith and 2 to 4 parts of Asarum herb. The traditional Chinese medicine composition has the advantages of good curative effect, fast action, no side effect, good stability, high drug availability, etc.; the preparation method is advanced; and clinical verification proves that the traditional Chinese medicine composition has an effective rate of 98% in treatment of glaucoma.
Owner:华梅
Sophora flavescens powder and preparation method and application thereof
ActiveCN106902147AImprove palatabilityImproved dissolution rate and dissolution rateAntibacterial agentsDigestive systemCross-linked polyethyleneAdhesive
The invention relates to the field of medicine and discloses a traditional Chinese medicine, specifically a Sophora flavescens powder and a preparation method and application thereof. The Sophora flavescens powder is mainly prepared by pelletizing a particle and a second adhesive. The particle is prepared by pelletizing Sophora flavescens fine powder and a first adhesive, wherein the first adhesive contains acrylic resin No.VI. The second adhesive contains one or more ingredients selected from a group consisting of xanthan gum, crosslinked periston, a licorice fluid extract and sodium dodecyl sulfate. By using acrylic resin No.VI for the first adhesive and by adding the second adhesive as a compounding component for forming synergism for gluing and pelletizing, the Sophora flavescens powder will not be disintegrated or slightly disintegrated in an aqueous solution and saliva during the production and application process. Thus, palatability during forage intake of livestock is enhanced, bioavailability is increased, functions are improved, and the application range for animals is widened.
Owner:绿色食品(海南自贸区)集团有限公司 +1
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