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31results about How to "High drug availability" patented technology

Drug-coating balloon catheter and production method and application thereof

The invention provides a drug-coating balloon catheter and a production method and application thereof. The method includes: preparing active drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active drug seed crystal suspension; adding the active drug seed crystal suspension, an active drug solution and an additive solution into different channels of a coating machine, mixing and atomizing the active drug seed crystal suspension, the active drug solution and the additive solution at the nozzle tip end of the ultrasonic sprayer of the coating machine, spraying to the surface of a balloon dilatation catheter to obtain drug coating with an appropriate crystal size, and performing homogenizing post-processing to obtain the drug-coating balloon catheter with homogeneous crystals. The drug-coating balloon catheter and the production method thereof have the advantages that the drug coating is firmly combined with a balloon, and drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the blood vessel wall of a lesion part is high, high drug loading efficiency is achieved, intravascular in-situ stenosis or restenosis can be treated effectively, the risks of late thrombosis and restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.
Owner:LEPU MEDICAL TECH (BEIJING) CO LTD

Synergistic treatment type multi-material sustained-release eye drop and preparation method

The invention discloses a synergistic treatment type multi-material sustained-release eye drop and a preparation method. The preparation method comprises the following steps of: instantaneously forming chitosan aqueous solution which is blended with therapeutic materials into superfine gel particles under the action of direct current high voltage static; receiving the particles by using hyaluronic acid hydrosol or hyaluronic acid hydrogel; and coating the surface of chitosan particles with a hyaluronic acid gel crust layer to obtain a medicament sustained-release eye drop, wherein the size of the chitosan gel particles can be accurately controlled by controlling voltage, the concentration of the chitosan solution and the distance from a jet orifice to the liquid level of the hyaluronic acid hydrosol, and the flowability of the eye drop can be regulated by controlling the concentration of the hyaluronic acid, so that the adhesive capacity of the eye drop to the eye surface and a long-term treatment effect are improved. The preparation method has simple and practicable process, high repeatability, and clean and pollution-free whole preparation process flow; and as the provided multi-therapeutic material sustained-release eye drop for synergistic treatment on eye diseases does not need complicated process, and the proportion of each component and the release rate are convenient to control, so the preparation method has a good application prospect.
Owner:ZHEJIANG UNIV

Compound herbal antibacterial liquid as well as preparation process and application thereof

PendingCN113332350AQuick resultsQuickly detoxify and reduce swellingAntibacterial agentsAntimycoticsChlorhexidine AcetateChlorhexidine
The invention provides compound herbal antibacterial liquid as well as a preparation process and application thereof. The compound herbal antibacterial liquid comprises the following raw materials: a medicinal plant leachate, sesame oil, borneol, peppermint oil, chlorhexidine acetate, coptis chinensis, scutellaria baicalensis, golden cypress, sanguisorba officinalis, rheum officinale, catechu and peppermint oil. The preparation process comprises the following steps: adding the coptis chinensis, the scutellaria baicalensis, the golden cypress, the sanguisorba officinalis, the rheum officinale and the catechu which are crushed into the peppermint oil, performing stirring, performing dipping and performing extracting for one month to obtain the medicinal plant leachate; taking out small medicine bags, adding the sesame oil, the borneol and the chlorhexidine acetate, performing uniform stirring, and finally performing filling and packaging. The compound herbal antibacterial liquid is an external antibacterial liquid with complete functions, can be at least used for treating scalp tinea, scald, mosquito bite, knife injury, fall injury, carbuncle, surgical scars and acne, is high in medicine availability, is not limited by age, gender and race, and is safe and reliable. Particularly, the compound herbal antibacterial liquid i has the advantages of quick detoxification and detumescence, quick tissue regeneration and close-up, quick pus extraction and poison drawing, quick incrustation and pain relief, quick astringency and hemostasis, and quick insect killing and itching relieving.
Owner:重庆兴皕堂生物科技有限公司

Preparation method of drug-coated balloon catheter, prepared drug-coated balloon catheter and application thereof

The invention provides a drug-coating balloon catheter and a production method and application thereof. The method includes: preparing active drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active drug seed crystal suspension; adding the active drug seed crystal suspension, an active drug solution and an additive solution into different channels of a coating machine, mixing and atomizing the active drug seed crystal suspension, the active drug solution and the additive solution at the nozzle tip end of the ultrasonic sprayer of the coating machine, spraying to the surface of a balloon dilatation catheter to obtain drug coating with an appropriate crystal size, and performing homogenizing post-processing to obtain the drug-coating balloon catheter with homogeneous crystals. The drug-coating balloon catheter and the production method thereof have the advantages that the drug coating is firmly combined with a balloon, and drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the blood vessel wall of a lesion part is high, high drug loading efficiency is achieved, intravascular in-situ stenosis or restenosis can be treated effectively, the risks of late thrombosis and restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.
Owner:LEPU MEDICAL TECH (BEIJING) CO LTD

Traditional Chinese medicine composition for treatment of infantile convulsion and preparation method of same

The invention relates to a traditional Chinese medicine composition for treatment of infantile convulsion and a preparation method of same. The traditional Chinese medicine composition is prepared from raw material medicines including, by weight, 18-22 parts of Chinese rhubarb, 18-22 parts of eretmochelys imbricata, 18-22 parts of herba schizonepetae, 18-22 parts of mangnolia officinalis, 13-17 parts of thunberg fritillary bulbs, 13-17 parts of pericarpium citri reticulatae, 13-17 parts of divaricate saposhnikovia root, 13-17 parts of rhizoma chuanxiong, 8-12 parts of tangerine peel, 8-12 parts of ochre, 8-12 parts of cinnabar, 8-12 parts of codonopsis pilosula, 8-12 parts of honey suckles, 8-12 parts of apricot kernels, 8-12 parts of cape jasmine, 8-12 parts of coptis chinensis, 5-7 parts of notopterygium roots, 5-7 parts of radix angelicae pubescentis, 5-7 parts of Chinese ephedra, 5-7 parts of angelica sinensis, 5-7 parts of white peony roots, and 5-7 parts of fructus lycii. The traditional Chinese medicine composition has good and quick curative effects, is free of side effects and has advanced preparation process, good preparation stability and high availability. Clinical test proves that the traditional Chinese medicine composition reaches 92.5% in effective rate for treatment of the infantile convulsion.
Owner:朱克兰

Chinese medicinal capsules for treating psoriasis, multiple kinds of stubborn dermatitis and pruritus

The invention relates to Chinese medicinal capsules for treating psoriasis, multiple kinds of stubborn dermatitis and pruritus. At present, most medicaments for treating the psoriasis, multiple kinds of stubborn dermatitis and the pruritus belong immunosuppressive agents, and have adverse effect on the normal immunologic function. The Chinese medicinal capsules comprise the following Chinese medicinal herbs in part by weight: 140 to 160 parts of incised notopterygium rhizome, 140 to 160 parts of gentiana macrophylla, 90 to 110 parts of figwort root, 90 to 110 parts of densefruit Pittany root-bark, 70 to 90 parts of nutgrass galingale rhizome, 50 to 70 parts of rhubarb, 90 to 110 parts of great burdock achene, 70 to 90 parts of cassia twig, 70 to 90 parts of cicada slough, 70 to 90 parts of stiff silkworm, 90 to 110 parts of beautiful sweetgum fruit, 90 to 110 parts of tree peony bark, 90 to 110 parts of rehmannia root and 140 to 160 parts of swordlike atractylodes rhizome. A preparation method comprises the following steps of: grinding the Chinese medicinal herbs into 200-mesh powder, mixing uniformly and filling the mixed powder into capsules to obtain the Chinese medicinal capsules. The Chinese medicinal capsules are used for treating the psoriasis, multiple kinds of stubborn dermatitis and the pruritus.
Owner:HEILONGJIANG HENGFA PHARMA

Traditional Chinese medicine composition for treating nasal polyp, and preparation method thereof

The invention relates to a traditional Chinese medicine composition for treating nasal polyp and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following bulk drugs by weight: 28 to 32 parts of oyster, 28 to 32 parts of coix seeds, 13 to 17 parts of Prunella vulgaris, 13 to 17 parts of Radix Codonopsis, 13 to 17 parts of Zhejiang fritillaria bulb, 13 to 17 parts of bitter orange fruit, 13 to 17 parts of kelp, 8 to 12 parts of peach seed, 8 to 12 parts of safflower, 8 to 12 parts of pinellia tuber, 8 to 12 parts of Arisaema cum Bile, 8 to 12 parts of Chinese honey locust spine, 8 to 12 parts of muscardine silkworm, 8 to 12 parts of safflower, 8 to 12 parts of root of large-flowered skullcap, 8 to 12 parts of loquat leaf, 5 to 7 parts of clove, 5 to 7 parts of Radix bupleuri, 5 to 7 parts of dried orange peel, 5 to 7 parts of akebia stem and 2 to 4 parts of Asarum herb. The traditional Chinese medicine composition has the advantages of good curative effect, fast action, no side effect, good stability, high drug availability, etc.; the preparation method is advanced; and clinical verification proves that the traditional Chinese medicine composition has an effective rate of 93% in treatment of nasal polyp.
Owner:华梅

Synergistic treatment type multi-material sustained-release eye drop and preparation method

The invention discloses a synergistic treatment type multi-material sustained-release eye drop and a preparation method. The preparation method comprises the following steps of: instantaneously forming chitosan aqueous solution which is blended with therapeutic materials into superfine gel particles under the action of direct current high voltage static; receiving the particles by using hyaluronic acid hydrosol or hyaluronic acid hydrogel; and coating the surface of chitosan particles with a hyaluronic acid gel crust layer to obtain a medicament sustained-release eye drop, wherein the size ofthe chitosan gel particles can be accurately controlled by controlling voltage, the concentration of the chitosan solution and the distance from a jet orifice to the liquid level of the hyaluronic acid hydrosol, and the flowability of the eye drop can be regulated by controlling the concentration of the hyaluronic acid, so that the adhesive capacity of the eye drop to the eye surface and a long-term treatment effect are improved. The preparation method has simple and practicable process, high repeatability, and clean and pollution-free whole preparation process flow; and as the provided multi-therapeutic material sustained-release eye drop for synergistic treatment on eye diseases does not need complicated process, and the proportion of each component and the release rate are convenient to control, so the preparation method has a good application prospect.
Owner:ZHEJIANG UNIV

Integrated equipment for dendrobium huoshanense juice processing, grinding and mixing

The invention discloses integrated equipment for dendrobium huoshanense juice processing, grinding and mixing. The integrated equipment comprises a machine body and electrical equipment, wherein a conical working groove and a discharging groove formed in the bottom of the working groove are formed in the machine body; a working shaft moving up and down is rotationally arranged in the working groove, the working shaft is conical, and a plurality of additional rings in contact connection with the groove wall of the working groove are fixed on the conical surface of the working shaft; a cover plate is fixed to the top of the working groove, a cutter rod and a hammer rod which synchronously move up and down are arranged above the machine body, and an impact hammer is fixed to the bottom of the hammer rod; a liquid outlet pipe and a residue outlet pipe which are symmetrically arranged communicate with the groove wall of the discharging groove, the liquid outlet pipe communicates with a filter box, and the residue outlet pipe communicates with a drying box; and a feeding hole communicating with the working groove is formed in one side of the machine body. According to the equipment, grinding, filtering and drying of dendrobium nobile are integrated in one piece of equipment, and the fresh dendrobium nobile is dissociated into dendrobium nobile juice and dried dendrobium nobile, so that the integration degree of the equipment is high, the dissociation degree is high, waste is reduced, high processing efficiency is guaranteed, and the medicinal utilization degree of the fresh dendrobium nobile is also high.
Owner:安徽霍山鹏泽生物科技有限公司

Preparation method of injectable hydrogel for controlled release of voriconazole intraocular drug

The invention discloses a preparation method for injectable hydrogel for controlled release of a voriconazole intraocular drug, and relates to the preparation method for injectable hydrogel. The preparation method aims to solve the problems that an existing voriconazole preparation is fast in metabolism and needs to be repeatedly supplied, the body pain and economic burden of a patient are increased, and an existing voriconazole sustained release system is poor in biocompatibility and poor in long-acting controlled-release effect. The method comprises the following steps of 1, preparing whiteflocculent polyaldehyde dextran; 2, preparing water-soluble linear poly-beta-cyclodextrin; and 3, firstly preparing a PBS solution of the water-soluble linear poly-beta-cyclodextrin with voriconazoleloaded in a cyclodextrin molecular cage, and then dissolving carboxymethyl chitosan into the PBS solution so as to obtain the injectable hydrogel for controlled release of the voriconazole intraoculardrug. According to the preparation method, the half-life of the prepared injectable hydrogel for controlled release of the voriconazole intraocular drug in a vitreous cavity is 30-60 days; and the injectable hydrogel for controlled release of the voriconazole intraocular drug can be obtained.
Owner:QINGDAO UNIV

Traditional Chinese medicine composition for treating glaucoma and preparation method thereof

The invention relates to a traditional Chinese medicine composition for treating glaucoma and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following bulk drugs by weight: 28 to 32 parts of Rhizoma Imperatae, 18 to 22 parts of Radix Codonopsis, 18 to 22 parts of motherwort, 18 to 22 parts of lotus leaf, 13 to 17 parts of tree peony bark, 13 to 17 parts of Chinese yam, 13 to 17 parts of oyster, 13 to 17 parts of Chinese magnoliavine fruit, 13 to 17 parts of Chinese rhubarb, 13 to 17 parts of Rhizoma Gastrodiae, 13 to 17 parts of dark plum, 8 to 12 parts of evodia fruit, 8 to 12 parts of Tribulus terrstris, 8 to 12 parts of red peony root, 8 to 12 parts of equisetum, 8 to 12 parts of safflower, 8 to 12 parts of glehnia root, 8 to 12 parts of toosendan fruit, 8 to 12 parts of Chinese gentian, 5 to 7 parts of ricepaperplant pith and 2 to 4 parts of Asarum herb. The traditional Chinese medicine composition has the advantages of good curative effect, fast action, no side effect, good stability, high drug availability, etc.; the preparation method is advanced; and clinical verification proves that the traditional Chinese medicine composition has an effective rate of 98% in treatment of glaucoma.
Owner:华梅
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