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Pharmaceutical composition containing cavidine total alkali and preparation method of pharmaceutical composition

A technology of cavedins and compositions, applied in the field of pharmaceutical compositions, can solve the problems of poor water solubility of cavedins, inability to reach a therapeutic dose, slow disintegration of ordinary tablets, etc., and achieves good stability and portability. The effect of convenience, good compliance and good taste

Active Publication Date: 2015-06-17
GUANGZHOU YIPINHONG PHARMA +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The active part preparation of the culvertin is a kind of active part preparation with special composition requirements and ratio requirements, and the total alkaloid content of the cuvitin is more than 70%, of which dehydrocarvitin (C20H22O4N) accounts for 0.5% of the total alkaloid- 99.5%, dehydroapocavidin 0.5%-99.5%, they are relatively poorly soluble in water, so the bioavailability is low
[0006] At present, only injections of Yanhuanglian preparations are on the market, such as injections produced by Guangxi Hefeng Pharmaceutical Co., Ltd., approved by the State Drug Administration Z20046725, with a specification of 2ml each and containing 0.7mg of dehydrocarvitin. , palpitation, chills, fever, vomiting and other allergic reactions, and the safety risk is relatively high, and the price is high
The company develops solid oral preparations of total alkaloids based on independent intellectual property rights, and has conducted research on ordinary tablets. reach an effective therapeutic dose

Method used

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  • Pharmaceutical composition containing cavidine total alkali and preparation method of pharmaceutical composition
  • Pharmaceutical composition containing cavidine total alkali and preparation method of pharmaceutical composition
  • Pharmaceutical composition containing cavidine total alkali and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Weigh 5 mg of total alkaloids of carvedins, 15 mg of precrosslinked starch, 10 mg of microcrystalline cellulose, 0.1 mg of sodium lauryl sulfate, 5 mg of crospovidone, 1 mg of croscarmellose sodium, and an appropriate amount of sweetener. Flavoring agent, pass through 80 mesh sieve, mix evenly, add dropwise 5% polyvinylpyrrolidone aqueous solution to make soft material, pass through 24 mesh sieve to granulate, dry the granules at 45-80°C, the water content reaches 0.5-10%, granulate, Add 0.15 mg of magnesium stearate, mix well, and press into tablets.

Embodiment 2

[0051] Weigh 5 mg of total alkaloids of carvedins, 15 mg of precross-linked starch, 10 mg of microcrystalline cellulose, 0.1 mg of sodium lauryl sulfate, 5 mg of crospovidone, 1 mg of croscarmellose sodium, and an appropriate amount of sweetener. Flavoring agent, pass through 80 mesh sieve, mix evenly, add dropwise 5% polyvinylpyrrolidone aqueous solution to make soft material, pass through 24 mesh sieve to granulate, dry the granules at 45-80°C, the water content reaches 0.5-10%, granulate, Add 0.15 mg of micropowder silica gel, mix well, and press into tablets to obtain.

Embodiment 3

[0053] Weigh 25 mg of total alkaloids of carvedins, 15 mg of pre-crossed starch, 50 mg of lactose, 0.5 mg of sodium lauryl sulfate, 5 mg of crospovidone, 10 mg of croscarmellose sodium, and an appropriate amount of sweetener, Pass through a 80-mesh sieve, mix evenly, add dropwise 5% polyvinylpyrrolidone aqueous solution to make soft material, pass through a 24-mesh sieve to granulate, dry the granules at 45-80°C, the moisture reaches 0.5-10%, granulate, add stearin Magnesium acid 1.2mg, mixed evenly, tableted.

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Abstract

The invention provides a pharmaceutical composition containing cavidine total alkali. The pharmaceutical composition is a dispersible tablet which comprises dehydrogenation cavidine alkaloid and pharmaceutical adjuvants. The composition comprises 1-300 parts of cavidine total alkali. The pharmaceutical adjuvants comprise 10-200 parts of a disintegrating agent, 0.1-10 parts of a lubricant, 0.1-10 parts of flow aid, 0-200 parts of filler, 0-100 parts of a binder, 0-200 parts of a sweller, 0-50 parts of a surfactant and 0-200 parts of a sweetening agent. The pharmaceutical composition (dispersible tablet) containing cavidine total alkali solves the problem that indissolvable drugs are low in dissolution rate, has good disintegration and dissolution performance as well as good dispersion uniformity and taste and is convenient to take and good in compliance. The medicine availability is remarkably improved, the onset time is accelerated and the effect is more remarkable.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing total alkaloids of carvetins and a preparation method thereof. The pharmaceutical composition is a dispersible tablet. Background technique [0002] Hepatitis B virus (Hepatitis B) is an infectious disease caused by DNA hepatotropic virus (HBV) and mainly manifested in liver inflammatory lesions. High-level characteristics are very harmful to human health and are a worldwide public health problem. About 400 million people in the world are chronically infected with HBV, mainly in Asian and African countries. my country is an area with a high incidence of viral hepatitis, mainly HBV infection. Epidemiological data show that there are 120 million HBsAg carriers in my country, and about 30 million chronic hepatitis B patients need treatment, seriously affecting people's life, employment, and even marriage. Although hepatitis B vaccine has been...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/66A61K31/4375
Inventor 李捍雄曾永长张莉颜稚宏
Owner GUANGZHOU YIPINHONG PHARMA
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