Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nano-gold coated layered double hydroxide composite material and its preparation and application

A double hydroxide, composite material technology, applied in the direction of drug combination, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of weak curative effect, poor drug availability, low targeting, etc. Circulation time in vivo, effect of high drug load

Active Publication Date: 2018-02-09
TONGJI UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the patent does not have composite gold nanoparticles, the targeting of the drug is relatively low, resulting in poor drug availability, resulting in relatively weak efficacy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nano-gold coated layered double hydroxide composite material and its preparation and application
  • Nano-gold coated layered double hydroxide composite material and its preparation and application
  • Nano-gold coated layered double hydroxide composite material and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] The preparation method of nano-gold coated layered double hydroxide composite material adopts the following steps:

[0038] (1) Preparation of nano-layered double hydroxide

[0039] a. Prepare a solution containing divalent metal ion salt and trivalent metal ion salt, the molar ratio between divalent metal ion salt and trivalent metal ion salt is 1:3;

[0040] b. Configure NaOH solution and 2 Stir at 60°C for 10 minutes under atmosphere;

[0041] c. Add the step a solution dropwise to the step b solution, N 2 Stirring was continued at 60°C for 3 h under atmosphere;

[0042] d. Take out the sample obtained after the reaction, wash it repeatedly with double distilled water after centrifugation and centrifuge it for 3 times, then put it in a hydrothermal kettle, and react at 100°C for 16h;

[0043] e. Centrifuge the obtained sample, remove the supernatant, place it in a vacuum drying oven at 50° C. for 48 hours and take it out after completely drying it, place it in a ...

Embodiment 1

[0052] Preparation of Nanolayered Double Hydroxide

[0053] Step a: Preparation of MgCl 2 ·6H 2 O (0.6099g, 0.003mol) and AlCl 3 9H 2 O (0.2414g, 0.001mol) metal mixed salt solution total 10mL

[0054] Step b: 40 mL of NaOH solution with a concentration of 0.0006 mol was placed in N 2 Stir at 60°C for 10 minutes under atmosphere

[0055] Step c: Add the solution of step a dropwise to the solution of step b, N 2 Stir at 60°C for 3 hours under atmosphere.

[0056] Step d: Take out the sample after the reaction, centrifuge, use ddH 2 O water was repeatedly washed and centrifuged three times, transferred to a hydrothermal kettle, placed in an oven, and reacted at 100°C for 16 hours.

[0057] Step e: Centrifuge the sample, pour off the supernatant, put it in a vacuum drying oven at 50°C for 48 hours, take it out, and grind it into powder in a mortar to obtain the sample. The electron microscope morphology is as follows figure 1 shown.

Embodiment 2

[0059] Preparation of gold nanoparticles.

[0060] Prepare tetra-n-octylammonium bromide (136.7mg, 0.25mmol), dodecylamine (111.2mg, 0.6mmol), and chloroauric acid (218.3mg, 0.53mmol) in 5mL of toluene. At room temperature, sodium borohydride (75.6 mg, 2 mmol) was added to the vigorously stirred solution above, and after 2 hours, high-speed centrifugation was performed to obtain oil-soluble gold nanoparticles. Dissolve the obtained nano-gold in 3 mL of chloroform, modify the surface of nano-gold with functionalized polyethylene glycol HS-PEG-COOH (molecular weight 2000 g / mol, 80 mg, 40 μmol) containing mercapto and carboxyl groups, and react at room temperature for 24 hours to obtain The stable 5nm nano-gold system in the water phase is used to interact with LDH, and its electron microscope morphology is as follows figure 2 shown.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a nano-gold-coated layered double hydroxide composite material and its preparation and application. The composite material has a core-shell structure, double hydroxide particles wrapped with nano-gold particles on the outside, and the average particle diameter of the nano-gold particles Less than 5nm, the particle size of double hydroxide particles is 20‑200nm, which can be applied to drug delivery. Compared with the prior art, the composite material prepared by the present invention has pH sensitivity, high drug loading capacity, field circulation in vivo, surface potential can be positively and negatively modified, and the surface can link ligands, antibodies, amination, carboxylation, Formylation, used as a drug carrier, achieves the dual effects of targeting and sustained release in vivo, and improves the drug's in vivo circulation time, drug availability, and drug targeting.

Description

technical field [0001] The invention relates to a drug-carrying system, in particular to a nano-gold-coated layered double hydroxide composite material and its preparation and application. Background technique [0002] Layered double hydroxide (LDH) is a new type of nano-inorganic functional material with a layered structure. In the LDH crystal structure, due to the influence of the minimum lattice energy effect and the lattice positioning effect, the metal ions in the The laminates are evenly distributed in a certain way, that is, in each tiny structural unit on the laminates, its chemical composition and structure remain unchanged, and the anions located between the layers are attracted by the charge of the laminates, repelled by the interlayer ions, Intra-layer space restrictions, etc., the distribution is also very uniform. [0003] Chinese patent CN104274838 A discloses the application of dexamethasone sodium phosphate / layered double hydroxide in asthma treatment and i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K31/704A61P35/00
Inventor 成昱朱融融
Owner TONGJI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com