Anionic-sodium-alginate-based production method of pH-responsive intestine-targeted active factor carrying system

A technology of sodium alginate and targeting activity, which is applied in the directions of organic active ingredients, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Broken and other problems, to achieve the effect of improving the embedding effect, low cost and easy large-scale production

Inactive Publication Date: 2020-05-05
DALIAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the pore size of the calcium alginate hydrogel network prepared by microfluidic technology is large, and it is easily broken after absorption and swelling, resulting in the rapid release of functional factors.

Method used

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  • Anionic-sodium-alginate-based production method of pH-responsive intestine-targeted active factor carrying system
  • Anionic-sodium-alginate-based production method of pH-responsive intestine-targeted active factor carrying system
  • Anionic-sodium-alginate-based production method of pH-responsive intestine-targeted active factor carrying system

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preparation example Construction

[0054] A preparation method of a pH-responsive intestinal targeting active factor delivery system based on anionic sodium alginate, using proanthocyanidin as the active factor, anionic sodium alginate as the wall material, and using microfluidic technology to prepare the active factor by using the in-situ gel method The delivery system was modified by layer-by-layer self-assembly of chitosan, and the embedding effect, stability, pH-stimulated release and targeting of the active factor delivery system were characterized. Including the following steps:

[0055] S1. Prepare internal phase proanthocyanidin-sodium carboxymethyl cellulose solution: mix the sodium carboxymethyl cellulose solution and proanthocyanidin aqueous solution evenly to obtain the internal phase; the final concentration of sodium carboxymethyl cellulose in the internal phase is 9-9. 11mg / mL, the final concentration of the proanthocyanidins is 4~6mg / mL;

[0056] S2. Prepare the interphase sodium alginate-edeta...

Embodiment 1

[0066] A preparation method of a pH-responsive intestinal targeting active factor delivery system based on anionic sodium alginate, comprising the steps of:

[0067] S1, preparation of inner phase proanthocyanidin-sodium carboxymethyl cellulose solution:

[0068] Add sodium carboxymethylcellulose into water, stir at 600 rpm for 6 hours until it dissolves, and prepare a sodium carboxymethylcellulose solution with a concentration of 20 mg / mL;

[0069] Take proanthocyanidins and add them to water, sonicate for 10 minutes under the condition of power 100W, and prepare an aqueous solution of proanthocyanidins with a concentration of 10mg / mL;

[0070] Mix the sodium carboxymethylcellulose solution with a concentration of 20 mg / mL and the aqueous solution of proanthocyanidins with a concentration of 10 mg / mL according to the volume ratio of 1:1 to obtain the inner phase;

[0071] S2. Preparation of mesophase sodium alginate-edetate disodium calcium solution:

[0072] Add sodium alg...

Embodiment 2

[0084] A preparation method of a pH-responsive intestinal targeting active factor delivery system based on anionic sodium alginate, comprising the steps of:

[0085] S1, preparation of inner phase proanthocyanidin-sodium carboxymethyl cellulose solution:

[0086] Add sodium carboxymethylcellulose into water, stir at 600 rpm for 6 hours until it dissolves, and prepare a sodium carboxymethylcellulose solution with a concentration of 20 mg / mL;

[0087] Take proanthocyanidins and add them to water, sonicate for 10 minutes under the condition of power 100W, and prepare an aqueous solution of proanthocyanidins with a concentration of 10 mg / mL;

[0088]Mix the sodium carboxymethylcellulose solution with a concentration of 20 mg / mL and the aqueous solution of proanthocyanidins with a concentration of 10 mg / mL according to the volume ratio of 1:1 to obtain the inner phase;

[0089] S2. Preparation of mesophase sodium alginate-edetate disodium calcium solution:

[0090] Add sodium alg...

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Abstract

The invention discloses an anionic-sodium-alginate-based production method of a pH-responsive intestine-targeted active factor carrying system, and belongs to the technical field of production of microcapsules. According to the anionic-sodium-alginate-based production method of the pH-responsive intestine-targeted active factor carrying system, with anionic polysaccharide sodium alginate as a wallmaterial, by adopting a microfluidic technology, by means of an in-situ inner and outer gel method, an active factor procyanidine is coated, then through layer-by-layer self-assembly, the surface ofcalcium alginate is modified with chitosan to form the pH-responsive intestine-targeted active factor carrying system with certain strength, uniform size and a shell-core structure, the stability of the procyanidine can be significantly improved, the procyanidine is protected from effects of factors of an external environment, a gastric fluid strong acid and the like, the procyanidine is transported to an intestinal tract part for release, the bioavailability of the procyanidine is improved, a novel idea is provided for development of the novel multifunctional active factor carrying system, and application of the novel multifunctional active factor carrying system in the field of food is promoted. The anionic-sodium-alginate-based production method of the pH-responsive intestine-targeted active factor carrying system is simple to operate, used materials are low in cost, embedding conditions are mild, and large-scale production is easy.

Description

technical field [0001] The invention belongs to the technical field of microcapsule preparation, and in particular relates to a preparation method of a pH-responsive intestinal targeting active factor delivery system based on anion sodium alginate. Background technique [0002] As an active factor, proanthocyanidins are currently internationally recognized as the most effective natural antioxidants for removing free radicals in the human body. Due to the active nature of its phenolic hydroxyl groups, many problems need to be solved in practical applications: 1) Poor stability. During storage and transportation, it is easily affected by environmental factors such as light and heat; 2) entering the human body through the oral cavity is sensitive to the low pH of the digestive juice and the action of enzymes. At present, various technologies are often used to prepare the carrier system to encapsulate proanthocyanidins, and to solve the problem of its stability by separating it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/353A61K47/36A61P39/06A23L33/105A23P10/30
CPCA61K9/5036A61K31/353A61P39/06A23L33/105A23P10/30A23V2002/00
Inventor 谭明乾铁珊珊张雪迪陈衍男李政梁铎李佳璇
Owner DALIAN POLYTECHNIC UNIVERSITY
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