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Preparation method of self healing hydrogel with ultraviolet and pH sensitive

A hydrogel and self-healing technology, which is applied in the field of rapid preparation of UV- and pH-sensitive self-healing hydrogels, which can solve the problems of poor biocompatibility, low self-healing efficiency, and self-healing hydrogel synthesis Complicated steps and other issues, to achieve the effect of obvious pH sensitivity and good mechanical properties

Active Publication Date: 2018-09-04
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the deficiencies of the above-mentioned prior art, the object of the present invention is to provide a method for preparing a self-healing hydrogel with dual responsiveness to ultraviolet light and pH, so as to solve the complex synthesis steps of the self-healing hydrogel in the prior art. , low self-healing efficiency, poor biocompatibility and other defects

Method used

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  • Preparation method of self healing hydrogel with ultraviolet and pH sensitive
  • Preparation method of self healing hydrogel with ultraviolet and pH sensitive
  • Preparation method of self healing hydrogel with ultraviolet and pH sensitive

Examples

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Embodiment 1

[0039] A method for preparing a UV-sensitive, pH-sensitive self-healing hydrogel, comprising the following steps:

[0040] Step 1. Preparation of azobenzene polymerizable monomer: add 5.70 g of p-aminoazobenzene monomer to a round bottom flask, stir and dissolve with 10 mL of toluene, then add 4.0 mL of triethylamine and 30 mg of hydroquinone in turn, at room temperature, While stirring, add methacryloyl chloride or acryloyl chloride 0.8 times the molar amount of azobenzene dropwise until an orange-red solid appears, stir and reflux at 55°C for three hours to react, after the end, cool, filter with suction, and vacuum dry at 55°C to remove toluene. The orange-red solid was washed with a small amount of distilled water, filtered with suction, vacuum-dried at 45°C to remove water, and recrystallized once in absolute ethanol to obtain orange-red crystals, which were dried in vacuum;

[0041] Step 2, to prepare the polymerizable monomer of phenylboronic acid, accurately weigh 1.50...

Embodiment 2

[0046] A method for preparing a UV-sensitive, pH-sensitive self-healing hydrogel, comprising the following steps:

[0047] Step 1, prepare azobenzene polymerizable monomer: add 6.00g of p-aminoazobenzene monomer into a round bottom flask, stir and dissolve with 20mL of toluene, add 4.2mL of triethylamine and 40mg of hydroquinone in turn, at room temperature, While stirring, add methacryloyl chloride or acryloyl chloride with 1.1 times the molar amount of azobenzene dropwise until an orange-red solid appears, stir and reflux at 65°C for three hours to react, after the end, cool, filter with suction, and dry toluene under vacuum at 65°C to obtain orange The red solid was washed with a small amount of distilled water, filtered with suction, dried under vacuum at 50°C to remove water, and recrystallized twice in absolute ethanol to obtain orange-red crystals, which were dried under vacuum;

[0048] Step 2, preparation of phenylboronic acid polymerizable monomer: accurately weigh 1...

Embodiment 3

[0053] A method for preparing a UV-sensitive, pH-sensitive self-healing hydrogel, comprising the following steps:

[0054] Step 1, prepare azobenzene polymerizable monomer: add 6.10g p-aminoazobenzene monomer into a round bottom flask, stir and dissolve with 40mL toluene, add 4.5mL triethylamine and 50mg hydroquinone in turn, at room temperature, While stirring, add methacryloyl chloride or acryloyl chloride 1.5 times the molar amount of azobenzene dropwise until an orange-red solid appears, stir and reflux at 70°C for three hours to react, after the end, cool, filter with suction, and dry toluene under vacuum at 70°C to obtain orange The red solid was washed with a small amount of distilled water, filtered with suction, dried under vacuum at 55°C to remove water, and recrystallized three times in absolute ethanol to obtain orange-red crystals, which were dried under vacuum;

[0055] Step 2, preparation of phenylboronic acid polymerizable monomer: accurately weigh 1.70g of 3-a...

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Abstract

The invention provides a preparation method of self healing hydrogel with ultraviolet and pH sensitive. The method comprises the following steps of 1, preparing azobenzene polymerizable monomers; forming subject-object inclusions by cyclodextrin and the azobenzene polymerizable monomers; 2, preparing phenylboronic acid polymerizable monomers; 3, forming crosslinking points under the basic condition through the reaction between the phenylboronic acid polymerizable monomers and cis-diol on cyclodextrin inclusions and performing liquid separation by a liquid separation funnel to obtain yellow emulsion at the lowermost layer which is the formed azobenzene cyclodextrin inclusions; 4, adding oxidization-reduction initiators, crosslinking agents and water-soluble monomers at the room temperatureto obtain the hydrogel with the ultraviolet and pH response performance and self healing performance. The simple synthesis steps are used; the physical non-covalency subject-object inclusion effect and the chemical covalency reversible boric acid ester bonds are used; the hydrogel with self healing function, pH sensitivity, high mechanical property and high stability is formed.

Description

technical field [0001] The invention belongs to the technical field of hydrogel preparation, in particular to a method for rapidly preparing self-healing hydrogel with ultraviolet and pH sensitivity. Specifically, cyclodextrin and azobenzene monomer are used to form host-guest inclusion complexation, and the cis-diol on the cyclodextrin forms a cross-link with the boronic acid group on the phenylboronic acid polymerizable monomer under alkaline conditions point, and then add water-soluble monomers and initiators to obtain the above gel with UV and pH dual responsiveness and self-healing water properties through polymerization. Background technique [0002] Gel is a polymer or macromolecular aggregate that can absorb a large amount of solvent but is insoluble in solvent. They can quickly swell and balance in water and can maintain their shape and three-dimensional space network structure, so they are called soft materials. Hydrogels are ubiquitous in natural systems, especia...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/06C08F220/20C08F220/56C08F220/54C08F222/14C08F222/38
CPCC08F251/00C08F222/102
Inventor 贾鹏翔杨萌程永斌马可
Owner NORTHWEST UNIV
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