Nano-gold-coated layered double hydroxide composite material and its preparation method and use

A technology of double hydroxide and composite materials, which is applied in the direction of drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of weak curative effect, poor drug availability, low targeting, etc., and achieve improved In vivo circulation time, effect of high drug loading

Active Publication Date: 2016-01-20
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the patent does not have composite gold nanoparticles, the targeting of the drug is relatively low, resulting in poor drug availability, resulting in relatively weak efficacy

Method used

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  • Nano-gold-coated layered double hydroxide composite material and its preparation method and use
  • Nano-gold-coated layered double hydroxide composite material and its preparation method and use
  • Nano-gold-coated layered double hydroxide composite material and its preparation method and use

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preparation example Construction

[0037] The preparation method of nano-gold coated layered double hydroxide composite material adopts the following steps:

[0038] (1) Preparation of nano-layered double hydroxide

[0039] a. Prepare a solution containing divalent metal ion salt and trivalent metal ion salt, the molar ratio between divalent metal ion salt and trivalent metal ion salt is 1:3;

[0040] b. Configure NaOH solution and 2 Stir at 60°C for 10 minutes under atmosphere;

[0041] c. Add the step a solution dropwise to the step b solution, N 2 Stirring was continued at 60°C for 3 h under atmosphere;

[0042] d. Take out the sample obtained after the reaction, wash it repeatedly with double distilled water after centrifugation and centrifuge it for 3 times, then put it in a hydrothermal kettle, and react at 100°C for 16h;

[0043] e. Centrifuge the obtained sample, remove the supernatant, place it in a vacuum drying oven at 50° C. for 48 hours and take it out after completely drying it, place it in a ...

Embodiment 1

[0052] Preparation of Nanolayered Double Hydroxide

[0053] Step a: Preparation of MgCl 2 ·6H 2 O (0.6099g, 0.003mol) and AlCl 3 9H 2 O (0.2414g, 0.001mol) metal mixed salt solution total 10mL

[0054] Step b: 40 mL of NaOH solution with a concentration of 0.0006 mol was placed in N 2 Stir at 60°C for 10 minutes under atmosphere

[0055] Step c: Add the solution of step a dropwise to the solution of step b, N 2 Stir at 60°C for 3 hours under atmosphere.

[0056] Step d: Take out the sample after the reaction, centrifuge, use ddH 2 O water was repeatedly washed and centrifuged three times, transferred to a hydrothermal kettle, placed in an oven, and reacted at 100°C for 16 hours.

[0057] Step e: Centrifuge the sample, pour off the supernatant, put it in a vacuum drying oven at 50°C for 48 hours, take it out, and grind it into powder in a mortar to obtain the sample. The electron microscope morphology is as follows figure 1 shown.

Embodiment 2

[0059] Preparation of gold nanoparticles.

[0060] Prepare tetra-n-octylammonium bromide (136.7mg, 0.25mmol), dodecylamine (111.2mg, 0.6mmol), and chloroauric acid (218.3mg, 0.53mmol) in 5mL of toluene. At room temperature, sodium borohydride (75.6 mg, 2 mmol) was added to the vigorously stirred solution above, and after 2 hours, high-speed centrifugation was performed to obtain oil-soluble gold nanoparticles. Dissolve the obtained nano-gold in 3 mL of chloroform, modify the surface of nano-gold with functionalized polyethylene glycol HS-PEG-COOH (molecular weight 2000 g / mol, 80 mg, 40 μmol) containing mercapto and carboxyl groups, and react at room temperature for 24 hours to obtain The stable 5nm nano-gold system in the water phase is used to interact with LDH, and its electron microscope morphology is as follows figure 2 shown.

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Abstract

The invention relates to a nano-gold-coated layered double hydroxide composite material and its preparation method and use. The composite material has a core-shell structure and comprises double hydroxide particles coated with nano-gold particles, the average particle size of the nano-gold particles is less than 5nm, and the particle size of the double hydroxide particles is in a range of 20-200nm. The nano-gold-coated layered double hydroxide composite material can be used for drug delivery. Compared with the existing double hydroxide composite material, the nano-gold-coated layered double hydroxide composite material has pH sensitivity, high drug load and internal field circularity. The surface of the nano-gold-coated layered double hydroxide composite material can be subjected to positive and negative modification, be connected to a ligand and an antibody, and be subjected to amination, carboxylation and formylation. The nano-gold-coated layered double hydroxide composite material can be used as a drug carrier, realizes targeting and slow release in vivo, and improves drug in-vivo cycle time, a drug utilization degree and drug targeting effects.

Description

technical field [0001] The invention relates to a drug-carrying system, in particular to a nano-gold-coated layered double hydroxide composite material and its preparation and application. Background technique [0002] Layered double hydroxide (LDH) is a new type of nano-inorganic functional material with a layered structure. In the LDH crystal structure, due to the influence of the minimum lattice energy effect and the lattice positioning effect, the metal ions in the The laminates are evenly distributed in a certain way, that is, in each tiny structural unit on the laminates, its chemical composition and structure remain unchanged, and the anions located between the layers are attracted by the charge of the laminates, repelled by the interlayer ions, Intra-layer space restrictions, etc., the distribution is also very uniform. [0003] Chinese patent CN104274838A discloses the application of dexamethasone sodium phosphate / layered double hydroxide in asthma treatment and it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K31/704A61P35/00
Inventor 成昱朱融融
Owner TONGJI UNIV
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