92results about How to "Not easy to wash off" patented technology

The invention provides a preparation method of potassium titanium hexacyanoferrate adopting tiny ball-shaped silicagel as carrier, which relates to a preparation method of high specific surface potassium titanium hexacyanoferrate adopting tiny ball-shaped silicagel as carrier. The method is that fashioned porous tiny ball-shaped silicagel under the protection of nitrogen and in the condition of heating and refluxing reacts with organic solvent solution of tetrabutyl titanate. The acquired tiny ball-shaped silicagel loaded with unformed titanium dioxide is dried, dipped in hydrochloric acid solution of kalium ferrocyanatum and then reacting for 12-24h to acquire the high specific surface potassium titanium hexacyanoferrate by adopting tiny the ball-shaped silicagel as carrier. Potassium titanium hexacyanoferrate in the material has adjustable loading amount, good adsorptivity to nuclides, high specific surface, good particle sphericility and solidity, and avoids over-limit moisture resistance of bed layer caused by exclusive use of potassium titanium hexacyanoferrate particles; moreover, owing to existence of Ti-O-Si covalent bond, potassium titanium hexacyanoferrate particles and tiny ball-shaped silicagel can link closely, and do not lose easily during the waste water disposal.

The invention provides a drug-coating balloon catheter and a production method and application thereof. The method includes: preparing active drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active drug seed crystal suspension; adding the active drug seed crystal suspension, an active drug solution and an additive solution into different channels of a coating machine, mixing and atomizing the active drug seed crystal suspension, the active drug solution and the additive solution at the nozzle tip end of the ultrasonic sprayer of the coating machine, spraying to the surface of a balloon dilatation catheter to obtain drug coating with an appropriate crystal size, and performing homogenizing post-processing to obtain the drug-coating balloon catheter with homogeneous crystals. The drug-coating balloon catheter and the production method thereof have the advantages that the drug coating is firmly combined with a balloon, and drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the blood vessel wall of a lesion part is high, high drug loading efficiency is achieved, intravascular in-situ stenosis or restenosis can be treated effectively, the risks of late thrombosis and restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.

The invention provides a preparation method of a crystal controllable drug balloon catheter, the prepared drug balloon catheter and application thereof. A low-pressure transverse ultrasonic spraying method is adopted to spray a drug coating on the surface of a balloon, and the crystal controllable drug balloon catheter is obtained. Controllable selection of drug coating crystal size can be achieved by adopting the low-pressure transverse ultrasonic spraying method, so that the drug coating on the surface of the balloon is more uniform, particles are more uniform, a drug solution can be flushed to the surface of the balloon through low-pressure transverse ultrasonic spraying, and the drug coating firmness is improved. The preparation method has a crystal controllable characteristic, the influence of environmental factors on the drug coating firmness and the crystalline state of an active drug contained in the drug coating can be also avoided, and the preparation method is simple and used for industrial production.

The invention discloses conductive polyurethane superfine fiber suede leather and a preparing method thereof. The preparing method comprises the steps of drying superfine fiber suede leather at a temperature in a range of 80 DEG C to 140 DEG C for 5 to 30 minutes, and impregnating the superfine fiber suede leather in a conductive solution for 5 to 50 seconds, wherein, the liquor ratio is between 1:1 and 1:20; and drying the impregnated solution at a temperature ranging from 80 DEG C to 140 DEG C for 5 to 30 minutes to obtain the conductive polyurethane superfine fiber suede leather. According to the conductive polyurethane superfine fiber suede leather and the preparing method thereof, preparing processes are all basic processes of synthetic leather businesses, no special requirements are asked for devices and process conditions, and the prepared conductive polyurethane superfine fiber suede leather can be applied to products of electronic touch screen gloves and the like and has enormous market prospects.

The invention discloses a rodlike manganese dioxide / polyaniline composite material and a preparation method thereof. The rodlike manganese dioxide / polyaniline composite material is of a one-dimensional rodlike structure, the size is 300-700nm, the mean diameter is 40-70nm, and the one-dimensional nanostructure has a relatively short ion transport distance in radial direction when the rodlike manganese dioxide / polyaniline composite material is used as an electrode material, so that the energy storage process can be accelerated, the influence caused by volume expansion in charging and discharging processes can be reduced by conductive polymer polyaniline coating the surface of the rodlike structure, the rodlike manganese dioxide / polyaniline composite material plays a role in stabilizing the MnO2 crystal structure, the utilization rate of MnO2 can be increased, and the dissolution of MnO2 is prevented, especially, the dissolution of MnO2 in an acidic electrolyte is prevented, the obtained composite material has relatively high conductivity; and the cycling stability and the rate capability of a battery can be greatly improved. The preparation method is simple, safe, environmentally friendly and suitable for popularization and application.

The invention relates to an MBBR (Moving Bed Biofilm Reactor) packing material negative pressure and positive pressure combined conveying method which is characterized by comprising the following steps of: collecting an MBBR packing material via an inlet water collecting pipeline in a vacuum type and connecting to a vacuum tank, connecting the top of the vacuum tank with a negative pressure generating apparatus via a pipeline, cutting off the vacuum after the MBBR packing material is collected to the vacuum tank, and opening a positive pressure pipeline communicated with the vacuum tank. A positive air pressure pipeline is also arranged at the top of the vacuum tank, the MBBR packing material is ejected to a water pool from a packing material ejection pipeline, and a water outlet pipe connected with the vacuum tank is communicated to the water inelt end of the MBBR water pool. With the method, the packing material is not easy to break, microorganisms on the surface of the packing material are not easy to flush away, and thus, the aerobic biochemical efficiency of a carrier is greatly improved. The purpose of conveying the MBBR packing material to a long distance can be achieved.

The invention discloses a water ceramic pigment and a production method thereof. The pigment consists of pigment base slurry and coloring material, wherein the pigment base slurry comprises water-soluble polyurethane resin, water-soluble acrylic resin, a pH regulator, dipropylene glycol butyl ether, antifoaming agent, flatting agent, thickener, ammonia water and other components. The water ceramic pigment can be directly used to draw pictures on the surfaces of smooth disks or other porcelain and glass products, does not need baking or drying, and is resistant to wash.

Provided are a modified nanometer bamboo charcoal mask and a manufacturing method thereof. The modified nanometer bamboo charcoal mask comprises an inner mask and an outer mask, wherein the inner mask is provided with a dismounting opening, and a filer layer is arranged in the dismounting opening. The inner mask and the outer mask of the mask and a filer layer base plate are made of an electrets melt-blowing polypropylene fiber non-woven fabrics, the filer layer uses chitosan as a capsule wall material, microcapsules are made from modified nanometer bamboo charcoal powder, beewax is used as an adhesive for arranging the microcapsules on the non-woven fabrics. The modified nanometer bamboo charcoal powder are modified by adopting nanometer titanium dioxide. The modified nanometer bamboo charcoal mask is green, environment-friendly, safe and efficient, has the broad-spectrum antibacterial effect and has good washability due to the fact that the beewax is used as the adhesive to arrange the microcapsules on the non-woven fabrics.

The invention discloses levofloxacin hydrochloride sustained-release eye drops which are ophthalmic preparations prepared by using levofloxacin hydrochloride as a pharmacodynamic raw material, matching with sodium hyaluronate to play a role of a thickener, and then matching with a metal ion complexing agent pharmaceutically acceptable to local parts of eyes, an osmotic pressure regulator and a pH regulator, wherein per 100 parts by weight of a finished product preparation contains 0.30-1.00 part by weight of levofloxacin hydrochloride and 0.1-1.00 part by weight of sodium hyaluronate. The medicine liquid provided by the invention has high viscosity, prolongs the time of medicine staying in the eyes, improves the absorption of the medicine, and improves the bioavailability of the eye drops; no preservative is added to the eye drops provided by the invention, so as to improve the biological safety of the eye drops.

The invention discloses a multifunctional aqueous nano-coating. The multifunctional aqueous nano-coating comprises the following components in parts by weight: 20-40 parts of water, modified cellulose ether, 2-amino-2-methyl-1-propanol, a dispersing agent, a polyether type surfactant, polydimethylsiloxane, polyoxyethylene polyoxypropylene glyceryl ether, a CMIT-MIT compound, 2,2,4-trimethyl pentanediol-1,3-monoisobutyrate, an anti-freezing agent, rutile type titanium dioxide, 25-50 parts of fillers, 0.2-1 part of nano-silver powder, polyorganosiloxane, 1-2 parts of fluoro-alkyl-polyether modified silicone, nano-titania aqueous colloid, an emulsion and a mildew preventive, wherein the main components of the CMIT-MIT compound are 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one. The multifunctional aqueous nano-coating has the efficacies of sterilization, formaldehyde purification and negative ion release; no harmful chemical substance is added in the whole process, and testing proves that the sterilization efficiency can reach above 99% within 24 hours, and the formaldehyde purification efficiency can reach above 80%.

The invention discloses a hair dye, which is composed of the following raw materials in percentage by weight: 20.0 to 30.0% of organic solvent, 0.50 to 1.0% of direct dye, 0.80 to 1.50% of thickening agent, 0.50 to 2.0% of polymer resin, 0.50 to 2.0% of amino end group polysiloxane, 0.20 to 0.50% of protein hydrolysate, and the balance being deionized water. The provided hair dye has a very good dyeing performance, is capable of improving the color fastness and performance on resisting shampoo washing, and effectively solves the problem of easy fading.

The invention relates to the technical field of antibacterial agents, and provides a lignin cationic surfactant, a preparation method thereof, a long-acting antibacterial agent and a preparation method of the long-acting antibacterial agent. Cheap and easily available natural material lignin is used as a raw material to prepare the surfactant, the obtained lignin cationic surfactant has hydrophilicity and stable performance, and when the lignin cationic surfactant is applied to the antibacterial agent, the wetting and permeation of the antibacterial agent are facilitated, and the coating effectiveness of the antibacterial agent is not influenced. The invention further provides the long-acting antibacterial agent. The long-acting antibacterial agent is prepared from a water-based long-chainsiloxy compound, the lignin cationic surfactant, an alcohol and an organic acid. The obtained antibacterial agent is stable in performance, high in binding force with the surface of a base material,not prone to being washed off, high in sterilization rate, high in sterilization speed and long in protection time, belongs to physical sterilization and is not prone to generating drug resistance.

The invention provides a preparation method of drug balloons as well as the drug balloons prepared by the preparation method and application thereof. The preparation method is characterized by comprising the following steps: curing chitosan to surfaces of balloons to obtain balloons with surfaces modified by the chitosan; spraying a drug solution on the obtained balloons with the surfaces modified by the chitosan to obtain the balloons with surfaces provided with drug coatings; carrying out surface solvation treatment on the balloons and carrying out segmented folding and packing to obtain the drug balloons. According to the drug balloons prepared by the preparation method provided by the invention, the drug coatings can be uniformly and firmly combined on the surfaces of the balloons and not easily fall off; drugs are prevented from being washed off in an in-vivo conveying process; the loss of drugs is reduced and the utilization rate of the drugs is improved; the preparation method provided by the invention is accurate, stable and efficient, is suitable for industrial large-scale production and has a wide application prospect.

The invention discloses a hair dye composition. The hair dye composition is prepared from a first component and a second component; the first component is prepared from a hair dye pigment intermediateand a first accessory; the hair dye pigment intermediate is one of 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or a mixture of the two; the second component is prepared from an oxidizing agent, metal ions and a second accessory. Through the above mode, the hair dye composition is capable of ensuring that a melanin component is fixedly loaded on the surface of hair better, and not easily washed away by water, has a very good hair dyeing effect, has no toxic and side effects nearly after applied to human hair, and has very high safety performance.

The invention relates to a polydopamine hair dye. The polydopamine hair dye comprises dopamine, tyrosine hydroxylase and a transition-metal chelator. The dopamine is self-assembled into nanoparticles in the presence of the tyrosine hydroxylase and the transition-metal chelator, and the nanoparticles can be adsorbed to the surface of hair. A weight ratio of the dopamine to the tyrosine hydroxylase to the transition-metal chelator is (20-10): (0.8-0.2): (3-0.15). The transition-metal chelator comprises one or more of copper ions, ferrous ions and ferric ions. The invention further discloses a preparation method for the polydopamine hair dye. The hair dye provided by the invention is of natural molecules and has good dyeing ability and biocompatibility. Compared with other commercial hair dyes and other polydopamine dyeing methods, the polydopamine hair dye has a higher hair dyeing speed and lighter environmental pollution under the same environmental conditions, is safe and effective, is convenient in use, can be applied to household hair dyeing scenes and has a good practical value.

The invention relates to a high-first-effect silicon-based negative electrode material and a preparation method thereof. The preparation method comprises: firstly, ball-milling, mixing and drying rawmaterials SiO and hydroxide according to a certain ratio; putting the dried mixed material into a quartz crucible, transferring into a rotary furnace, heating and carrying out heat treatment for a certain time; heating to a certain temperature at a certain rate, introducing a carbon source, carrying out carbon coating for a certain time, cooling to room temperature, and taking out the material; and pickling the material to be neutral, and drying to obtain the material. The invention discloses a high-first-effect negative electrode material. The weakly alkaline hydroxide is utilized to corrodethe SiO surface at a high temperature to form a Si-SiO-SiO<2> core-shell structure; meanwhile, a layer of inert silicate product is used as a buffer layer, so that on one hand, the consumption of lithium ions caused by SEI film formation in the first charge-discharge process can be reduced, the first effect of the material is improved, andrelatively high first charge-discharge capacity and cyclingstability can be maintained; and on the other hand, the disproportionation reaction of SiO and carbon coating are completed by a one-step method, so that the production time and cost are greatly reduced, and industrialization is easy.

The invention discloses a nano water-repellent down production process, and relates to the technical field of down production. The process comprises the following steps that S1, a down material is immersed in a pre-treatment liquid for pre-treatment at first; S2, a finishing agent is prepared, wherein the finishing agent is prepared from, by weight, 50-80 parts of nano silica, 10-20 parts of a dispersant, 30-40 parts of nano microcrystalline cellulose, 20-30 parts of fatty alcohol ether phosphate and 800-1,000 parts of water; S3, the down is added into a washing stirrer at first, and then water and the finishing agent are added for stirring and mixing; S4, the stirred down is rinsed with clear water 10 times; S5, the rinsed down is spin-dried and dewatered; S6, the dewatered down is put into a drying box for stirring and drying. The process has the advantage that the adhesion tightness of the nano silica and the nano microcrystalline cellulose to the surface of the down is improved.

The invention provides an environment-friendly bamboo charcoal mask and a manufacturing method thereof. The mask comprises an inner mask body and an outer mask body, the inner mask body is provided with a detachment opening, a filtering layer is arranged in the detachment opening, the inner mask body, the outer mask body and the filtering layer are all made of electret melt-blown polypropylene fiber non-woven fabrics, chitosan serves as a capsule wall material of the filtering layer, nanometer bamboo charcoal powder serves as a core material to be made into micro capsules, and the microcapsules are arranged on the non-woven fabrics through beewax serving as adhesive agents. The chitosan, the bamboo charcoal powder and the beewax are all natural materials, the obtained product is environmentally friendly, safe and efficient and has a broad-spectrum antibacterial function, the microcapsules are arranged on the non-woven fabrics through the beewax serving as the adhesive agents, and good washability is achieved.

The invention provides an aromaticity bamboo charcoal fiber and a preparation method thereof in order to meet demands of clients in a product market and solve the problem that the conventional bamboo charcoal viscose fiber is poor in spinning property. The aromaticity bamboo charcoal fiber is characterized in that a finished product is obtained by taking cellulose fiber pulp as a raw material, mixing an aromaticity bamboo charcoal solution and viscose through injection before spinning and performing wet spinning and post-treatment, wherein the aromaticity bamboo charcoal solution is prepared by mixing fragrant masterbatches and a bamboo charcoal solution; the fragrant masterbatches contain perfumes; the fragrant perfume content of the fiber is 0.01-10 percent; the bamboo charcoal content is 0.1-10 percent; the ammonia absorption rate is more than or equal to 50 percent; the air permeability is more than or equal to 500mm / s; the color fastness to washing is of 4-5 level. The aromaticity bamboo charcoal fiber disclosed by the invention has the functions of bacterium and ultraviolet prevention and deodorization, is high in air permeability and hygroscopicity, can effectively and continuously scatter fragrance and has the effects of relieving pressure and enabling people to be invigorating.

The invention discloses a PVDF polymer separation membrane and a preparation method thereof, and according to the method, a layer of alkyl anion compound capable of resisting alkali liquid attack is formed on the surface of a PVDF membrane material, so that the purpose of improving the alkali corrosion resistance of the PVDF membrane material is achieved. The method comprises the following steps:mixing PVDF powder, hydrophilic nano silicon dioxide and a pore-foaming agent (such as PVP, PEG and the like) solution by adopting a solution blending method, performing non-solvent induced phase separation (NIPS) to form a membrane, lightly wiping redundant moisture on the surface of the membrane, then putting the membrane into a 5-10% anionic surfactant aqueous phase solution, and performing ultrasonic soaking for 3-5 minutes until the membrane is completely soaked; taking out and removing redundant liquid drops on the surface of the membrane, hanging and airing; putting the air-dried PVDF membrane into a 5-14% alkali-resistant resin solution, taking out the PVDF membrane after the PVDF membrane is completely soaked, lightly wiping off redundant resin on the surface of the membrane, andthen putting the membrane under an ultraviolet lamp for ultraviolet radiation curing for 30-90s, so as to obtain the alkali-resistant membrane.

The application discloses a quantum dot light emitting diode, a display panel and a manufacturing method, which are used to retain more quantum dots when patterning a quantum dot layer. The QLED includes an electron transport layer with plurality of holes, and a quantum dot light emitting layer located on the electron transport layer. The electron transport layer directly contacts the quantum dotlight emitting layer.

The invention discloses a preparation method for an antibacterial textile. The preparation method comprises the steps of preparation of an antibacterial liquid, primary impregnation, primary extrusion, primary drying, secondary impregnation, secondary extrusion, secondary drying, water washing and oven drying. Raw materials of the antibacterial liquid are natural, good in antibacterial effect and harmless to a human body, and can be adsorbed onto the textile during impregnation; due to the step of secondary impregnation in the preparation method, the antibacterial liquid can be better adsorbed onto the textile, is hard to wash away, and has a lasting antibacterial effect; meanwhile, the preparation method is simple, scientific and safe.

The invention relates to a non-paddle bypass type underwater pushing, transporting and stirring method, which pushes, transports and stirs floating packing by a bypass type underwater propeller. The structure of the bypass type underwater propeller is the structure of a pipeline or the structure of a cylinder. The pipeline or the cylinder is internally provided with a tapered port, the pipe diameter of which is gradually reduced; the pipeline or the cylinder is perpendicularly connected with a pressure water inlet pipe in a communicating way, or is connected with the pressure water inlet pipe in an angle in a communicating way, and the pressure water inlet pipe is communicated to the position of the tapered port with gradually reduced diameter; and water flow of the pressure water inlet pipe flows forward to the tip part of the outside of the tapered port, and drives packing water in the pipeline move forward along the tip part of the tapered port. The non-paddle bypass type underwater pushing, transporting and stirring method provided by the invention is hard to break the packing, the broken packing not only causes the biochemical efficiency reduction of the water body but also the cleaning cost enhancement, and micro-organism is also hard to rush down on the surface of the packing, thus the effects of the pushing, transporting and stirring functions are favorable. Moreover, the non-paddle bypass type underwater pushing, transporting and stirring method enhances efficiency of MBB process, and reduces energy consumption.

The invention provides a raising method for manufacturing flannelette. The raising method comprises the following raising steps that S1, a to-be-raised fabric is dipped in an antistatic raising coating agent, then taken out and dried at 100-120 DEG C; S2, needling raising is carried out on the to-be-raised fabric dipped with the antistatic raising coating agent through a needling raising agent; and S3, a brightener is added into the raised fabric in the step S2, and then the fabric is lustred, so that the fluff of the fabric is fluffy. The antistatic raising coating agent is added into the fabric before raising, the emulsifying and lubricating effects are achieved, the dynamic friction coefficient of the surface of the fabric is small, and raising steel needles can enter the space between the fabric; and meanwhile, the stone needle powder and the tourmaline powder added into the fabric have the powder lubricating effect, the powder is guided among fibers of the fabric under the fluffing action of the steel needles, so that the formed flannelette has a health-care effect.

The invention discloses a poly(p-phenylene vinylene) precursor, a preparation method thereof and application of the poly(p-phenylene vinylene) precursor to high-molecular fluorescent microspheres. The preparation method includes taking hydroquinone as a starting material, substituting bromoacetic acid for hydrogen on a phenolic hydroxyl group to obtain p-phenoxy diacetate, introducing bromomethyl into an ortho-position of acetoxy on a benzene ring, substituting a thiophene group for bromine to obtain a polymer monomer, and preparing the poly(p-phenylene vinylene) precursor with carboxyls on a pendant group in an alkaline aqueous solution environment. The poly(p-phenylene vinylene) precursor is loaded on every matrix microsphere with amino or hydroxyl on the surface, and temperature is controlled during thermal elimination, so that the high-molecular fluorescent microspheres with different fluorescence emission wavelengths are obtained. The microspheres obtained from the poly(p-phenylene vinylene) precursor with a great number of carboxyls on the pendant group demonstrate the biological molecular reaction site characteristic from the surfaces, and accordingly the application field of the microspheres is expanded.

The invention relates to the softener field, in particular to a clothing softener and a preparation method thereof. The clothing softener provided by the invention is mainly composed of the following components by weight percentage: 10-20% of dodecyl glucoside, 10-15% of dodecyl hydroxyethyl betaine, 0.1-3% of chitosan, 1-5% of octadecyl ethylene urea, 1-3% of polyoxypropyl vinyl ether, 0.1-0.5% of hydroxypropyl methyl cellulose, 0.5-1% of sweet orange essential oil, 0.5-2% of polyether F38, and 51-77% of water. The clothing softener provided by the invention has softening, sterilizing and anti-static effects. In addition, the clothing softener provided by the invention also can enhance the wrinkle resistance and fiber elasticity of clothing, at the same time can emit fresh scent, and has the efficacy of pleasuring the body and mind.

The invention discloses a method of preparing high purity zinc phosphate by a mechanical activation continuous reaction. The method comprises the following steps: S1, dissolving soluble carbonate or hydrogen carbonate and soluble zinc salt in water, separately to prepare a carbonate or hydrogen carbonate solution and a zinc salt solution; S2, mechanically activating the zinc salt solution and thecarbonate or hydrogen carbonate solution in a first reaction kettle synergically in a wet process for a reaction to prepare a precipitate; S3, conveying the precipitate and a solution to a second reaction kettle, adding a phosphoric acid solution, and carrying out a reaction in a mechanical activating condition in a synergic wet process to prepare zinc phosphate. The yield of the obtained productreaches 97.89-98.34%, the content of zinc phosphate dehydrate is 99.27-99.56%, the content of sulfate radicals is 0.032-0.041%, the content of chlorine ions is 0.028-0.042% and the content of lead is0.0012-0.0019%. Compared with the prior art, the output and quality of the product are superior.

The invention discloses a medicine balloon and a preparation method and application thereof, and relates to the technical field of medical instruments.The preparation method of the medicine balloon comprises the steps that an active medicine or the active medicine and auxiliary materials are prepared into micron or nano particles with sustained and controlled release, and the micron or nano particles, polyethylene glycol and phospholipid form a mixed solution; and then curing the mixed solution to the surface of the balloon, and then carrying out solvation treatment and sectioning and packaging to obtain the drug balloon. Through the implementation of the preparation method, the drug coating can be uniformly and firmly combined on the surface of the balloon, the drug is prevented from being washed off in the in-vivo conveying process, the drug loss is reduced, the drug utilization rate is improved, and the preparation method is accurate, stable and efficient, is suitable for industrial large-scale production and has a wide application prospect.

The invention discloses a leather substance making-replica retro process. The leather substance making-replica retro process comprises the following steps that firstly, a leather substance purchased from the market is soaked in saline water with the mass fraction of 20-30% for 1-2h; the leather substance is taken out and subjected to liquid dropping for 5-10min; then the surface of the leather substance is rinsed with a low-concentration ethanol solution and subjected to liquid dropping after rinsing; a grinding machine is used for grinding the leather substance, and a retro agent with the temperature of 40-50 DEG C is sprayed on the surface of the leather substance while grinding; after grinding, the leather substance is air-dried at room temperature; then the leather substance is coloredas needed; and finally the leather substance is ground and polished. The leather substance making-replica retro process is simple and easy to operate, and treating fluid used is safe and environmentally friendly and is suitable for industrial production.

The invention provides a drug-coating balloon catheter and a production method and application thereof. The method includes: preparing active drug seed crystals, and screening the seed crystals 1-3 micrometers in length to prepare active drug seed crystal suspension; adding the active drug seed crystal suspension, an active drug solution and an additive solution into different channels of a coating machine, mixing and atomizing the active drug seed crystal suspension, the active drug solution and the additive solution at the nozzle tip end of the ultrasonic sprayer of the coating machine, spraying to the surface of a balloon dilatation catheter to obtain drug coating with an appropriate crystal size, and performing homogenizing post-processing to obtain the drug-coating balloon catheter with homogeneous crystals. The drug-coating balloon catheter and the production method thereof have the advantages that the drug coating is firmly combined with a balloon, and drug crystals are even and complete; small drug loss during balloon preparation and in-vivo conveying can be guaranteed, concentration of effective drugs entering the blood vessel wall of a lesion part is high, high drug loading efficiency is achieved, intravascular in-situ stenosis or restenosis can be treated effectively, the risks of late thrombosis and restenosis are reduced, and the positive remodeling of blood vessels can be formed at the same time.